[ CSPS Pharmaceuticals, Inc. ] [ SPYDER ]

5Z.COM HOME
MOLECULAR DIVERSITY
DIVERSITY INFORMATION PAGES

Articles thru 2003
Articles 2004
Reviews
SPOS Papers
SPPS Papers
Robotics/Automation
Classics
Patents
Books
Procedures
Symposia
Companies
Suppliers
Scientists
Graffiti Wall
Links
Jobs
Hot News
Site News
Fun

PAPERS PUBLISHED IN 1997

This list is arranged by the name of the first author. Please, note the change in numbering of the references. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.


Recently added entries are marked in bold

  1. Anonymous. (1997) Combinatorial chemistry. Chemtech, 27, 3-3. #9395

  2. Anonymous. (1997) Combinatorial chemistry to develop new drugs. Canc. J. Sci. Amer., 3, 312-313. #9888

  3. Abraham, D. (1997) Combining legal and business strategies to develop combinatorial chemistry businesses. Nat. Biotech., 15, 679-682. #9358

  4. Adamczyk, M., Gebler, J.C., & Grote, J. (1997) The utility of enzymes in generating molecular diversity. Lipase mediated amidation of polybenzyl esters. Bioorg. Med. Chem. Lett., 7, 1027-1030. #10085

  5. Adams, E., Basten, A., Rodda, S., & Britton, W.J. (1997) Human T-cell clones to the 70-kilodalton heat shock protein of mycobacterium leprae define myobacterium-specific epitopes rather than shaped epitopes. Infec. Immunity, 65, 1061-1070. #9550

  6. Adey, N.B., & Kay, B.K. (1997) Isolation of peptides from phage-displayed random peptide libraries that interact with the talin-binding domain of vinculin. Biochem. J., 324, 523-528. #9190

  7. Agrafiotis, D.K. (1997) Stochastic algorithms for maximizing molecular diversity. Journal of Chemical Information and Computer Sciences, 37, 841-851. #8721

  8. Akada, R., Yamamoto, J., & Yamashita, I. (1997) Screening and identification of yeast sequences that cause growth inhibition when overexpressed. Mol. Gen. Genet., 254, 267-274. #12481

  9. Akaji, K., & Kiso, Y. (1997) Macrocyclization on solid support using Heck reaction. Tetrahedron Lett., 38, 5185-5188. #9035

  10. Alajoki, M.L., Baxter, G.T., Bemiss, W.R., Blau, D., Bousse, L.J., Chan, S.D.H., Dawes, T.D., Hahnenberger, K.M., Hamilton, J.M., Lam, P., McReynolds, R.J., Modlin, D.N., Owicki, J.C., Parce, J.W., Redington, D., Stevenson, K., Wada, H.G. & Williams, J. (1997) High-performance microphysiometry in drug discovery. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 427-442). Marcel Dekker,Inc., New York. #9011

  11. Allee, C. (1997) Systems integration. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 583-598). Marcel Dekker,Inc., New York. #9022

  12. Ammosova, T.N., Ouporov, I.V., Rubtsova, M.Y., Ignatenko, O.V., Egorov, A.M., Kolesanova, E.F., & Archakov, A.I. (1997) Epitope mapping of horseradish peroxidase (isoenzyme C). Biochemistry-Engl. Tr., 62, 440-447. #9217

  13. An, H.Y., Cummins, L.L., Griffey, R.H., Bharadwaj, R., Haly, B.D., Fraser, A.S., Wilson-Lingardo, L., Risen, L.M., Wyatt, J.R., & Cook, P.D. (1997) Solution phase combinatorial chemistry: Discovery of novel polyazapyridinophanes with potent antibacterial activity by a solution phase simultaneous addition of functionalities approach [review]. J. Amer. Chem. Soc., 119, 3696-3708. #9137

  14. An, H.Y., Haly, B.D., Fraser, A.S., Guinosso, C.J., & Cook, P.D. (1997) Solution phase combinatorial chemistry. Synthesis of novel linear pyridinopolyamine libraries with potent antibacterial activity. J. Org. Chem., 62, 5156-5164. #9440

  15. Anand, N., Jain, S., & Sinha, N. (1997) Molecular diversity generation through reactive lactams. J. Ind. Chem. Soc., 74, 948-954. #10989

  16. Armstrong, R.W., Brown, S.D., Keating, T.A. & Tempest, P.A. (1997) Combinatorial synthesis exploiting multiple-component condensations, microchip encoding, and resin capture. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 153-190). John Wiley & Sons,Inc., New York. #8357

  17. Arnau, J., & Sorensen, K.I. (1997) The isolation of novel heat shock genes in Lactococcus lactis using RNA subtractive hybridization. Gene, 188, 229-234. #12482

  18. Arnold, D., Keilholz, W., Schild, H., Dumrese, T., Stevanovic, S., & Rammensee, H.G. (1997) Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools. Eur. J. Biochem., 249, 171-179. #10103

  19. Arumugam, V., Routledge, A., Abell, C., & Balasubramanian, S. (1997) Synthesis of 2-oxindole derivatives via the intramolecular Heck reaction on solid support. Tetrahedron Lett., 38, 6473-6476. #9321

  20. Arya, P., & Ben, R.N. (1997) Combinatorial chemistry for the synthesis of carbohydrate libraries. Angew. Chem. Int. Ed., 36, 1280-1282. #9481

  21. Arza, B., Felez, J., Lopezalemany, R., Miles, L.A., & Munozcanoves, P. (1997) Identification of an epitope of alpha-enolase (a candidate plasminogen receptor) by phage display. Thromb. Haemost., 78, 1097-1103. #10106

  22. Atrash, B., & Bradley, M. (1997) A pH cleavable linker for zone diffusion assays and single bead solution screens in combinatorial chemistry. Chem. Commun., 1397-1398. #9527

  23. Aujame, L., Sodoyer, R., & Teillaud, J.L. (1997) Phage display and antibody engineering: A French overview. Trends Biotech., 15, 155-157. #10462

  24. Avalle, B., Vanwetswinkel, S., & Fastrez, J. (1997) In vitro selection for catalytic turnover from a library of beta-lactamase mutants and penicilin-binding proteins. Bioorg. Med. Chem. Lett., 7, 479-484. #10022

  25. Babiak, J. (1997) Management and service issues of a centralized robotic HTS core. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 461-470). Marcel Dekker,Inc., New York. #9014

  26. Babiak, J. Transforming your robotics into an infrastructure for the future. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.35 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8282

  27. Baca, M., Scanlan, T.S., Stephenson, R.C., & Wells, J.A. (1997) Phage display of a catalytic antibody to optimize affinity for transition-state analog binding. Proc. Natl. Acad. Sci. USA, 94, 10063-10068. #10107

  28. Backes, B.J., & Ellman, J.A. (1997) Solid support linker strategies. Curr. Opin. Chem. Biol., 1, 86-93. #8746

  29. Bailey, N., Cooper, A.W.J., Deal, M.J., Dean, A.W., Gore, A.L., Hawes, M.C., Judd, D.B., Merritt, A.T., Storer, R., Travers, S., & Watson, S.P. (1997) Solution-phase combinatorial chemistry in lead discovery. Chimia, 51, 832-837. #9733

  30. Balass, M., Katchalski-Katzir, E., & Fuchs, S. (1997) The alpha-bungarotoxin binding site on the nicotinic acetylcholine receptor: Analysis using a phage-epitope library. Proc. Natl. Acad. Sci. USA, 94, 6054-6058. #9188

  31. Balcer-Kubiczek, E.K., Meltzer, S.J., Han, L.H., Zhang, X.F., Shi, Z.M., Harrison, G.H., & Abraham, J.M. (1997) Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells. Oncogene, 14, 3051-3057. #12483

  32. Balding, D.J., & Torney, D.C. (1997) The design of pooling experiments for screening a clone map. Fungal Genet. Biol., 21, 302-307. #12484

  33. Baldino, C.M., Casebier, D.S., Caserta, J., Slobodkin, G., Tu, C., & Coffen, D.L. (1997) Convergent parallel synthesis. Synlett, 488-490. #9077

  34. Baldwin, J.J. & Dolle, R. (1997) Deconvolution tools for solid-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 153-174). American Chemical Society, Washington,DC. #11698

  35. Baldwin, J.J. & Henderson, I. (1997) Synthesis of encoded small molecule combinatorial libraries via ECLiPS. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 167-190). Marcel Dekker,Inc., New York. #8993

  36. Baldwin, J.J. & Dolle, R.E. (1997) Deconvolution methods in solid-phase synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 287-297). ESCOM, Leiden. #8629

  37. Banks, M., Fogarty, S., Valler, M., Mills, K., O'Brien, S., Binnie, A., and Houston, J. Automated high throughput screening to aid the drug hunter at Glaxo Wellcome. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.220 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8306

  38. Banville, S. C. and Zuckermann, R. N. Accelerating drug discovery by high-throughput combinatorial synthesis. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.77 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8285

  39. Barany, G., Albericio, F., Kates, S.A., & Kempe, M. (1997) Polyethylene glycol-containing supports for solid phase synthesis of peptides and combinatorial organic libraries. Polym. Preprint., 38, 587-588. #8520

  40. Barany, G., Albericio, F., Kates, S.A., & Kempe, M. (1997) Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries. ACS Symp. Ser., 680, 239-264. #9612

  41. Barany, G. & Kempe, M. (1997) The contex of solid-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 51-97). American Chemical Society, Washington,DC. #11696

  42. Barnard, J.M., & Downs, G.M. (1997) Computer representation and manipulation of combinatorial libraries [review]. Perspect. Drug Disc. Design, 7-8, 13-30. #10724

  43. Bastien, N., Trudel, M., & Simard, C. (1997) Protective immune responses induced by the immunization of mice with a recombinant bacteriophage displaying an epitope of the human respiratory syncytial virus. Virology, 234, 118-122. #9444

  44. Bauer, B.E. (1997) Database systems. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 551-582). Marcel Dekker,Inc., New York. #9021

  45. Bauer, U., Ho, W.B., & Koskinen, A.M.P. (1997) A novel linkage for the solid-phase synthesis of hydroxamic acids. Tetrahedron Lett., 38, 7233-7236. #9563

  46. Baxter, A.D. (1997) Meeting client needs in combinatorial chemistry: A service company perspective. Drug Disc. Today, 2, 307-308. #9429

  47. Baxter, A.D. (1997) Synthesis utilizing insoluble polymers: New reactions and small molecules. Curr. Opin. Chem. Biol., 1, 79-85. #8739

  48. Beggs, M. Use of a two armed Zymark robot for high throughput screening. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.206 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8305

  49. Beggs, M. & Major, J.S. (1997) Flexible use of people and machines. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 471-482). Marcel Dekker,Inc., New York. #9015

  50. Beggs, M. (1997) Use of a two-armed Zymark robot for high throughput screening. J. Biomol. Screen., 2, 71-78. #9841

  51. Bellott, E.M., Bondaryk, R., & Luther, A.L. (1997) Combinatorial chemistry in the drug discovery process. Clin. Res. Regul. Affairs, 14, 231-241. #12202

  52. Benecke, C., Gruner, T., Kerber, A., Laue, R., & Wieland, T. (1997) Molecular structure generation with molgen, new features and future developments. Fresenius J. Anal. Chem., 359, 23-32. #10116

  53. Benkovic, S., Miller, G.P., Zong, W. & Smiley, J. (1997) Combinatorial libraries of peptides, proteins, and antibodies using biological systems. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 241-260). John Wiley & Sons,Inc., New York. #8361

  54. Beresini, M.H., Sadick, M.D., Galloway, A.L., Yen, R., Yeh, S.H., Chang, A.C., Shelton, D.L. & Wong, W.L.T. (1997) Assays for small molecule agonists and antagonists of the neurotrophin receptors. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 329-344). Marcel Dekker,Inc., New York. #9004

  55. Berk, S.C., & Chapman, K.T. (1997) Spatially arrayed mixture (SPAM) technology: Synthesis of two-dimensionally indexed orthogonal combinatorial libraries. Bioorg. Med. Chem. Lett., 7, 837-842. #9256

  56. Berlin, K., Jain, R.K., Tetzlaff, C., Steinbeck, C., & Richert, C. (1997) Spectrometrically monitored selection experiments: Quantitative laser desorption mass spectrometry of small chemical libraries. Chem. Biol., 4, 63-77. #8400

  57. Beutel, B.A. (1997) Discovery and identification of lead compounds from combinatorial mixtures. Annu. Rep. Med. Chem., 32, 261-268. #9698

  58. Bhagwat, S.S., & Williams, M. (1997) P2 purine and pyrimidine receptors: Emerging superfamilies of G-protein-coupled and ligand-gated ion channel receptors [review]. Eur. J. Med. Chem., 32, 183-193. #9244

  59. Bhalay, G., Blaney, P., Palmer, V.H., & Baxter, A.D. (1997) Solid-phase synthesis of diverse tetrahydro-1,4-benzodiazepine-2-ones. Tetrahedron Lett., 38, 8375-8378. #9674

  60. Biebricher, C.K., & Gardiner, W.C. (1997) Molecular evolution of RNA in vitro. Biophys. Chem., 66, 179-192. #10119

  61. Birkenmeier, G., Osman, A.A., Kopperschlager, G., & Mothes, T. (1997) Epitope mapping by screening of phage display libraries of a monoclonal antibody directed against the receptor binding domain of human alpha-2-macroglobulin. FEBS Lett., 416, 193-196. #10120

  62. Bishop, A.C., Moore, D., Scanlan, T.S., & Shokat, K.M. (1997) Screening a hydroxystilbene library for selective inhibition of the b cell antigen receptor kinase cascade. Tetrahedron, 53, 11995-12004. #10121

  63. Bitan, G., Sukhotinsky, I., Mashriki, Y., Hanani, M., Selinger, Z., & Gilon, C. (1997) Synthesis and biological activity of novel backbone-bicyclic substance-P analogs containing lactam and disulfide bridges. J. Pept. Res., 49, 421-426. #9198

  64. Blackburn, C., Pingali, A., Kehoe, T., Herman, L.W., Wang, H.Q., & Kates, S.A. (1997) Libraries of angiotensin converting enzyme inhibitors: Solid-phase synthesis and affinity selection. Bioorg. Med. Chem. Lett., 7, 823-826. #9255

  65. Blackburn, C., & Kates, S.A. (1997) Solid-phase synthesis of cyclic homodetic peptides. Methods Enzymol., 289, 175-198. #9857

  66. Blackburn, C., Albericio, F., & Kates, S.A. (1997) Functionalized resins and linkers for solid-phase synthesis of small molecules. Drugs Future, 22, 1007-1025. #9840

  67. Blanchard, B.J., Konopka, G., Russell, M., & Ingram, V.M. (1997) Mechanism and prevention of neurotoxicity caused by beta-amyloid peptides: Relation to Alzheimer's-disease. Brain Res., 776, 40-50. #10122

  68. Blaney, J.M., & Martin, E.J. (1997) Computational approaches for combinatorial library design and molecular diversity analysis. Curr. Opin. Chem. Biol., 1, 54-59. #8715

  69. Bloxham, D. P. The current status and future of drug discovery. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.7.4.1 #8890

  70. Boder, E.T., & Wittrup, K.D. (1997) Yeast surface display for screening combinatorial polypeptide libraries. Nat. Biotech., 15, 553-557. #9194

  71. Boger, D.L., Chai, W., Ozer, R.S., & Andersson, C.M. (1997) Solution-phase combinatorial synthesis via the olefin metathesis reaction. Bioorg. Med. Chem. Lett., 7, 463-468. #10021

  72. Boger, D.L., Ozer, R.S., & Andersson, C.M. (1997) Generation of targeted C(2)-symmetrical compound libraries by solution-phase combinatorial chemistry. Bioorg. Med. Chem. Lett., 7, 1903-1908. #9425

  73. Bojanic, D., Keighley, W.W., Russell, M.J. & Wood, T.P. (1997) Factors for the successful integration of assays, equipment, robotics, and software. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 493-508). Marcel Dekker,Inc., New York. #9017

  74. Bolton, G.L., Hodges, J.C., & Rubin, J.R. (1997) Solid phase synthesis of fused bicyclic amino acid derivatives via intramolecular Pauson-Khand cyclization: Versatile scaffolds for combinatorial chemistry. Tetrahedron, 53, 6611-6634. #8636

  75. Bone, R. & Salemme, F.R. (1997) The integration of structure-based design and directed combinatorial chemistry for new pharmaceutical discovery. In P. Veerapandian (Ed.), Structure-Based Drug Design. (pp. 525-539). Marcel Dekker, New York. #11242

  76. Bonnycastle, L.L., Brown, K.L., Tang, J., & Scott, J.K. (1997) Assaying phage-borne peptides by phage capture on fibrinogen or streptavidin. Biol. Chem., 378, 509-515. #10475

  77. Boojamra, C.G., Burow, K.M., Thompson, L.A., & Ellman, J.A. (1997) Solid-phase synthesis of 1,4-benzodiazepine-2,5-diones. Library preparation and demonstration of synthesis generality. J. Org. Chem., 62, 1240-1256. #8522

  78. Booth, R.J., & Hodges, J.C. (1997) Polymer-supported quenching reagent for parallel purification. J. Amer. Chem. Soc., 119, 4882-4886. #8643

  79. Borchardt, A., Liberles, S.D., Biggar, S.R., Crabtree, G.R., & Schreiber, S.L. (1997) Small molecule-dependent genetic selection in stochastic nanodroplets as a means of detecting protein-ligand interactions on a large scale. Chem. Biol., 4, 961-968. #10124

  80. Bottger, A., Bottger, V., Garcia-Echeverria, C., Chene, P., Hochkeppel, H.K., Sampson, W., Ang, K., Howard, S.F., Picksley, S.M., & Lane, D.P. (1997) Molecular characterization of the hdm2-p53 interaction. J. Mol. Biol., 269, 744-756. #10470

  81. Boumrah, D., Campbell, M.M., Fenner, S., & Kinsman, R.G. (1997) Spacer molecules in peptide sequences: Incorporation into analogues of atrial natriuretic factor. Tetrahedron, 53, 6977-6992. #9106

  82. Boutin, J.A., Gesson, I., Henlin, J.M., Bertin, S., Lambert, P.H., Volland, J.P., & Fauchere, J.L. (1997) Limitations of the coupling of amino acid mixtures for the preparation of equimolar peptide libraries. Mol. Diversity, 3, 43-60. #10098

  83. Bozicevic, K. (1997) Patent strategies in molecular diversity. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 298-313). ESCOM, Leiden. #8630

  84. Bradley, E.K., Kerr, J.M., Richter, L.S., Figliozzi, G.M., Goff, D.A., Zuckermann, R.N., Spellmeyer, D.C., & Blaney, J.M. (1997) NMR structural characterization of oligo-N-substituted glycine lead compounds from a combinatorial library. Mol. Diversity, 3, 1-15. #10096

  85. Brady, P.A., & Sanders, J.K. (1997) Selection approaches to catalytic systems [review]. Chem. Soc. Rev., 26, 327-336. #10126

  86. Brandt, D.W. (1997) Multiplexed nanoliter transfers for high throughput drug screening using the Biomek 2000 and the high density replicating tool. J. Biomol. Screen., 2, 111-116. #9843

  87. Bray, A.M. (1997) Multiple peptide synthesis with commercially available Multipin kits. In I. Lefkovits (Ed.), Immunology Methods Manual. (pp. 809-816). Academic Press, San Diego. #9738

  88. Breaker, R.R. (1997) In vitro selection of catalytic polynucleotides. Chem. Rev., 97, 371-390. #8565

  89. Breaker, R.R. (1997) DNA aptamers and DNA enzymes. Curr. Opin. Chem. Biol., 1, 26-31. #8712

  90. Bristol, J.A. (1997) Applications of solid-supported organic synthesis in combinatorial chemistry: Preface. Tetrahedron, 53, xiii-xiii. #9112

  91. Broughton, H.B. (1997) Molecular modeling. Curr. Opin. Chem. Biol., 1, 392-398. #10127

  92. Brown, A.R., Rees, D.C., Rankovic, Z., & Morphy, J.R. (1997) Synthesis of tertiary amines using a polystyrene (REM) resin. J. Amer. Chem. Soc., 119, 3288-3295. #9152

  93. Brown, B.A., Cain, M., Broadbent, J., Tompkins, S., Henrich, G., Joseph, R., Casto, S., Harney, H., Greene, R., Delmondo, R. & Ng, S. (1997) FlashPlate(TM) technology. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 317-328). Marcel Dekker,Inc., New York. #9003

  94. Brown, D. (1997) Future pathways for combinatorial chemistry. Mol. Diversity, 2, 217-222. #8869

  95. Brown, E.G., & Nuss, J.M. (1997) Alkylation of Rink's amide linker on polystyrene resin: A reductive amination approach to modified amine-linkers for the solid phase synthesis of N-substituted amide derivatives. Tetrahedron Lett., 38, 8457-8460. #9691

  96. Brown, P.J., Smitholiver, T.A., Charifson, P.S., Tomkinson, N.C., Fivush, A.M., Sternbach, D.D., Wade, L.E., Orband-Miller, L.A., Parks, D.J., Blanchard, S.G., Kliewer, S.A., Lehmann, J.M., & Willson, T.M. (1997) Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library. Chem. Biol., 4, 909-918. #10129

  97. Brown, P.J., Hurley, K.P., Stuart, L.W., & Willson, T.M. (1997) Generation of secondary alkyl amines on solid support by borane reduction: Application to the parallel synthesis of PPAR ligands. Synthesis-Stuttgart, 778-782. #9411

  98. Brown, R.D., & Martin, Y.C. (1997) The information content of 2D and 3D structural descriptors relevant to ligand-receptor binding. Journal of Chemical Information and Computer Sciences, 37, 1-9. #8717

  99. Brown, R.D., & Martin, Y.C. (1997) Designing combinatorial library mixtures using a genetic algorithm. J. Med. Chem., 40, 2304-2313. #9457

  100. Brown, R.D. (1997) Descriptors for diversity analysis [review]. Perspect. Drug Disc. Design, 7-8, 31-49. #10725

  101. Brown, R.K. & Proulx, A. (1997) Accelerating the discovery process with automation and robotics: A sure bet or a risky venture? In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 509-524). Marcel Dekker,Inc., New York. #9018

  102. Brown, S.D., & Armstrong, R.W. (1997) Parallel synthesis of tamoxifen and derivatives on solid support via resin capture. J. Org. Chem., 62, 7076-7077. #9630

  103. Bruice, T.W., & Lima, W.F. (1997) Control of complexity constraints on combinatorial screening for preferred oligonucleotide hybridization sites on structured RNA. Biochemistry, 36, 5004-5019. #9252

  104. Bruno, J.G., Chang, M.N., Choisledeski, Y.M., Green, D.M., Mcgarry, D.G., Regan, J.R., & Volz, F.A. (1997) Synthesis of functionalized aromatic oligomers from a versatile diphenylmethane template. J. Org. Chem., 62, 5174-5190. #9441

  105. Bunin, B.A., Plunkett, M.J., Ellman, J.A., & Bray, A.M. (1997) The synthesis of a 1680 member 1,4-benzodiazepine library. New J. Chem., 21, 125-130. #9068

  106. Burbaum, J.J., & Sigal, N.H. (1997) New technologies for high-throughput screening. Curr. Opin. Chem. Biol., 1, 72-78. #8738

  107. Burger, M.T., & Still, W.C. (1997) Simple structural requirements for sequence-selective peptide receptors: Tripeptide binding by a podand ionophore. J. Org. Chem., 62, 4785-4790. #9469

  108. Burgess, K., Li, W., Linthicum, D.S., Ni, Q., Pledger, D., Rothman, R.B., & Shitangkoon, A. (1997) Libraries of opiate and anti-opiate peptidomimetics containing 2,3-methanoleucine. Bioorg. Med. Chem., 5, 1867-1871. #10131

  109. Burgess, K., Ibarzo, J., Linthicum, D.S., Russell, D.H., Shin, H., Shitangkoon, A., Totani, R., & Zhang, A.J. (1997) Solid phase syntheses of oligoureas. J. Amer. Chem. Soc., 119, 1556-1564. #8395

  110. Burgess, K., Lim, D., Bois-Choussy, M., & Zhu, J. (1997) Rapid and efficient solid phase syntheses of cyclic peptides with endocyclic biaryl ether bonds. Tetrahedron Lett., 38, 3345-3348. #8804

  111. Burioni, R., Plaisant, P., Dellicarri, V., Vannini, A., Spanu, T., Clementi, M., Fadda, G., & Varaldo, P.E. (1997) An improved phage display vector for antibody repertoire cloning by construction of combinatorial libraries. Res. Virol., 148, 161-164. #9277

  112. Burmeister, J., Von Kiedrowski, G., & Ellington, A.D. (1997) Cofactor-assisted self-cleavage in DNA libraries with a 3'-5'-phosphoramidate bond. Angew. Chem. Int. Ed., 36, 1321-1324. #12485

  113. Byk, G., Frederic, M., & Scherman, D. (1997) One pot synthesis of unsymetrically functionalized polyamines by a solid phase startegy starting from their symmetrical polyamine-counterparts. Tetrahedron Lett., 38, 3219-3222. #8798

  114. Byrgesen, E., Nielsen, J., Willert, M., & Bols, M. (1997) Combinatorial chemistry of piperidine based carbohydrate mimics. Tetrahedron Lett., 38, 5697-5700. #9412

  115. C&EN. (1997) Unique excitation emission forms basis of new taggants. C&EN, 75, 24. #8728

  116. Cabilly, S. (1997) Combinatorial Peptide Library Protocols. Humana Press, Inc., Totowa. ISBN 0896033929 #10544

  117. Caflisch, A. & Karplus, M. (1997) Structure-based combinatorial ligand design. In P. Veerapandian (Ed.), Structure-Based Drug Design. (pp. 541-558). Marcel Dekker, New York. #11380

  118. Campbell, J. B. and Wildonger, R. A. Managing compound library production by parallel synthesis on automated workstation-based systems. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.127 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8294

  119. Cantley, L. Use of soluble peptide libraries to define optimal motifs for protein interactions in signal transduction. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.3.1.1 #8882

  120. Cargill, J. The use of reactive fragment structure transformations for automated structure generation in automated combinatorial chemistry with applications to diversity analysis. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.399 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8327

  121. Cargill, J.F., & Lebl, M. (1997) New methods in combinatorial chemistry: Robotics and parallel synthesis. Curr. Opin. Chem. Biol., 1, 67-71. #8737

  122. Carle-Urioste, J.C., Brendel, V., & Walbot, V. (1997) A combinatorial role for exon, intron and splice site sequences in splicing in maize. Plant J., 11, 1253-1263. #10451

  123. Carlton, R.A., Orton, E., Lyman, C.E., & Roberts, J.E. (1997) Qualitative analysis of solid phase synthesis reaction products by X-ray spectrometry. Microscopy & Microanalysis, 3, 520-529. #10134

  124. Carrasco, M.R., Fitzgerald, M.C., Oda, Y., & Kent, S.B.H. (1997) Direct monitoring of organic reactions on polymeric supports. Tetrahedron Lett., 38, 6331-6334. #9318

  125. Carter, P., & Merchant, A.M. (1997) Engineering antibodies for imaging and therapy. Curr. Opin. Biotechnol., 8, 449-454. #10452

  126. Cattani, P., Rossolini, G.M., Cresti, S., Santangelo, R., Burton, D.R., Williamson, R.A., Sanna, P.P., & Fadda, G. (1997) Detection and typing of herpes simplex viruses by using recombinant immunoglobulin fragments produced in bacterial. J. Clin. Microbiol., 35, 1504-1509. #9069

  127. Cavalla, D. (1997) Architecture of R&D: A conceptual framework for collaboration. Drug Disc. Today, 2, 200-205. #9850

  128. Ceulemans, G., Vanaerschot, A., Wroblowski, B., Rozenski, J., Hendrix, C., & Herdewijn, P. (1997) Oligonucleotide analogues with 4-hydroxy-n-acetylprolinol as sugar substitute. Chem. Eur. J., 3, 1997-2010. #10137

  129. Chan, T.Y., Chen, R., Sofia, M.J., Smith, B.C., & Glennon, D. (1997) High throughput on-bead monitoring of solid phase reactions by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS). Tetrahedron Lett., 38, 2821-2824. #8786

  130. Charlton, J., Smith, D., & Kirschenheuter, G.P. (1997) Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library. Biochemistry, 36, 3018-3026. #9353

  131. Chen, C., Ahlberg Randall, L.A., Miller, R.B., Jones, A.D., & Kurth, M.J. (1997) The solid-phase combinatorial synthesis of beta-thioketones. Tetrahedron, 53, 6595-6609. #8637

  132. Chen, J.J., & Spatola, A.F. (1997) Solid phase synthesis of peptide hydroxamic acids. Tetrahedron Lett., 38, 1511-1514. #8374

  133. Chen, S., & Janda, K.D. (1997) Synthesis of prostaglandin E2 methyl ester on a soluble-polymer support for the construction of prostanoid libraries. J. Amer. Chem. Soc., 119, 8724-8725. #10139

  134. Cheng, X.J., Boyer, J.L., & Juliano, R.L. (1997) Selection of peptides that functionally replace a zinc finger in the sp1 transcription factor by using a yeast combinatorial library. Proc. Natl. Acad. Sci. USA, 94, 14120-14125. #10140

  135. Cheng, Y., & Chapman, K.T. (1997) Solid phase synthesis of spiroindoline. Tetrahedron Lett., 38, 1497-1500. #8373

  136. Cheruvallath, Z.S., Krotz, A.H., Cole, D.L., & Ravikumar, V.T. (1997) Solution phase synthesis of an oligodeoxyribonucleotide phosphorothioate for therapeutic applications. Nucleosides Nucleotides, 16, 1625-1628. #10141

  137. Cheung, Y.W., Abell, C., & Balasubramanian, S. (1997) A combinatorial approach to identifying protein tyrosine phosphatase substrates from a phosphotyrosine peptide library. J. Amer. Chem. Soc., 119, 9568-9569. #10142

  138. Chin, J., Fell, B., Shapiro, M.J., Tomesch, J., Wareing, J.R., & Bray, A.M. (1997) Magic angle spinning NMR for reaction monitoring and structure determination of molecules attached to multipin crowns. J. Org. Chem., 62, 538-539. #8405

  139. Chirinos-Rojas, C.L., Steward, M.W., & Partidos, C.D. (1997) Of a solid-phase random peptide library to identify inhibitors of TNF-alpha mediated cytotoxicity in vitro. Cytokine, 9, 226-232. #9258

  140. Chng, B.L., & Ganesan, A. (1997) Solution-phase synthesis of a beta-amino alcohol combinatorial library. Bioorg. Med. Chem. Lett., 7, 1511-1514. #9512

  141. Cho, B., Taylor, D.C., Nicholas, H.B.Jr., & Schmidt, F.J. (1997) Interacting RNA species identified by combinatorial selection. Bioorg. Med. Chem., 5, 1107-1113. #12537

  142. Choi, S.J., Ahn, M., Lee, J.S., & Jung, W.J. (1997) Selection of a high affinity angiogenin-binding peptide from a peptide library displayed on phage coat protein. Molecules and Cells, 7, 575-581. #10143

  143. Chowdhury, P.S., Chang, K., & Pastan, I. (1997) Isolation of anti-mesothelin antibodies from phage dispaly libraries. Mol. Immunol., 34, 9-20. #10079

  144. Christie, B.D. & Nourse, J.G. (1997) Modern chemical and biological databases. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 267-272). ESCOM, Leiden. #8627

  145. Clark, R.D. (1997) OptiSim: An extended dissimilarity selection method for finding diverse representative subsets. Journal of Chemical Information and Computer Sciences, 37, 1181-1188. #9846

  146. Clark, R.D., & Cramer, R.D. (1997) Taming the combinatorial centipede. Chemtech, 27, 24-31. #12095

  147. Coe, D.M. & Storer, R. (1997) Solution-phase combinatorial chemistry. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 50-58). ESCOM, Leiden. #8616

  148. Collini, M.D., & Ellingboe, J.W. (1997) The solid phase synthesis of tri-substituted indoles. Tetrahedron Lett., 38, 7963-7966. #9615

  149. Collins, J. (1997) Phage display. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 210-262). ESCOM, Leiden. #8625

  150. Conti, P., Demont, D., Cals, J., Ottenheijm, H.C.J., & Leysen, D. (1997) A new cleavage strategy for the solid-phase synthesis of secondary amines. Tetrahedron Lett., 38, 2915-2918. #8789

  151. Cook, J. S., Hynd, B., Kozikowski, B., McOsker, C. C., Paugh, D., Rasmusen, K., Sway, J., and Whitten, J. Establishing a high throughput screening facility. At Procter & Gamble Pharmaceuticals. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.197 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8304

  152. Corbett, J.W., Graciani, N.R., Mousa, S.A., & DeGrado, W.F. (1997) Solid-phase synthesis of a selective alpha(v)beta(3) integrin antagonist library. Bioorg. Med. Chem. Lett., 7, 1371-1376. #9183

  153. Cormack, P.A., Moore, B.D., & Sherrington, D.C. (1997) Monodisperse liquid crystalline peptides. J. Material. Chem., 7, 1977-1983. #10147

  154. Couet, J., Li, S., Okamoto, T., Ikezu, T., & Lisanti, M.P. (1997) Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. Journal of Biological Chemistry, 272, 6525-6533. #10441

  155. Cowley, P.M., & Rees, D.C. (1997) Applications of solid-phase synthesis to drug discovery. Curr. Med. Chem., 4, 211-227. #11243

  156. Craig, F.F. (1997) Screening of combinatorial libraries. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 399-412). American Chemical Society, Washington,DC. #11413

  157. Crameri, A., Dawes, G., Rodriguez, E.Jr., Silver, S., & Stemmer, W.P.C. (1997) Molecular evolution of an arsenate detoxification pathway DNA shuffling. Nat. Biotech., 15, 436-438. #9240

  158. Crawshaw, M., Hird, N.W., Irie, K., & Nagai, K. (1997) Synthesis of 3,4,5-trisubstituted cyclohexanones by cycloaddition to solid phase 2-aminobutadienes. Tetrahedron Lett., 38, 7115-7118. #9578

  159. Cunningham, B.C., & Wells, J.A. (1997) Minimized proteins. Curr. Opin. Struct. Biol., 7, 457-462. #9427

  160. Cuny, G.D., Cao, J., & Hauske, J.R. (1997) Ring opening cross-metathesis on solid support. Tetrahedron Lett., 38, 5237-5240. #9051

  161. Cwirla, S.E., Balasubramanian, P., Duffin, D.J., Wagstrom, C.R., Gates, C.M., Singer, S.C., Davis, A.M., Tansik, R.L., Mattheakis, L.C., Boytos, C.M., Schatz, P.J., Baccanari, D.P., Wrighton, N.C., Barrett, R.W., & Dower, W.J. (1997) Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science, 276, 1696-1699. #9082

  162. Czarnik, A.W., & DeWitt, S.H. (1997) A Practical Guide to Combinatorial Chemistry. American Chemical Society, Washington,DC. ISBN 084123485X #9826

  163. Czarnik, A.W. (1997) Encoding methods for combinatorial chemistry. Curr. Opin. Chem. Biol., 1, 60-66. #8723

  164. Czarnik, A.W. (1997) Combinatorial chemistry. Curr. Opin. Chem. Biol., 1, 1-2. #8707

  165. Czarnik, A.W. (1997) Encoding strategies in combinatorial chemistry. Proc. Natl. Acad. Sci. USA, 94, 12738-12739. #9883

  166. D'Mello, F., Partidos, C.D., Steward, M.W., & Howard, C.R. (1997) Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries. Virology, 237, 319-326. #12486

  167. Dahiyat, B.I., & Mayo, S.L. (1997) De novo protein design: Fully automated sequence selection. Science, 278, 82-87. #9956

  168. Dalvit, C., & Bohlen, J.M. (1997) Analysis of biofluids and chemical mixtures in non-deuterated solvents with H-1 diffusion-weighted pfg phase-sensitive double-quantum NMR spectroscopy. NMR Biomed., 10, 285-291. #10152

  169. Daniel, S., Caillatzucman, S., Hammer, J., Bach, J.F., & Vanendert, P.M. (1997) Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection. Journal of Immunology, 159, 2350-2357. #10153

  170. Dankwardt, S.M., Smith, D.B., Porco, J.A.Jr., & Nguyen, C.H. (1997) Solid-phase synthesis of N-alkyl sulfonamides. Synlett, 854-856. #9523

  171. Darvas, F. & Kovacs, L. (1997) CMT: A solution phase combinatorial chemistry approach: Synthesis and yield prediction of phenazines. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 223-242). Marcel Dekker,Inc., New York. #8996

  172. Das, B.C., & Iqbal, J. (1997) Polyaniline supported cobalt(II)-salen catalyst: One pot synthesis of beta-phenylisoserine derivatives from cinnamoyl amide. Tetrahedron Lett., 38, 2903-2906. #8787

  173. Davenport, M.P., Smith, K.J., Barouch, D., Reid, S.W., Bodnar, W.M., Willis, A.C., Hunt, D.F., & Hill, A.V.S. (1997) HLA class I binding motifs derived from random peptide libraries differ at the COOH terminus from those of eluted peptides. J. Exp. Med., 185, 367-371. #8236

  174. Davies, M., & Bradley, M. (1997) Inverted peptides: Single bead analysis by methionine scanning and mass spectrometry. Tetrahedron Lett., 38, 8565-8568. #9672

  175. Davies, M., & Bradley, M. (1997) C-terminally modified peptides and peptide libraries: Another end to peptide synthesis. Angew. Chem. Int. Ed., 36, 1097-1099. #12487

  176. Dawson, P.E., Fitzgerald, M.C., Muir, T.W., & Kent, S.B. (1997) Methods for the chemical synthesis and readout of self-encoded arrays of polypeptide analogues. J. Amer. Chem. Soc., 119, 7917-7927. #10155

  177. De, A., Ghosh, S., & Iqbal, J. (1997) A remarkable stereocontrol during cobalt(II) chloride catalyzed opening of cinnamoyl epoxydes with N-substituted anilines. Tetrahedron Lett., 38, 8379-8382. #9676

  178. Deben, I.E.A., Vanwijk, T.H.M., Vandoornum, E.M., Hermkens, P.H.H., & Kellenbach, E.R. (1997) Characterization of reaction products on solid supports by FT-IR. Mikrochim. Acta, 245-246. #9132

  179. Del Nery, E., Juliano, M.A., Meldal, M., Svendsen, I., Scharfstein, J., Walmsley, A., & Juliano, L. (1997) Characterization of the substrate specificity of the major cysteine protease (cruzipain) from Trypanosoma cruzi using a portion-mixing combinatorial library and fluorogenic peptides. Biochem. J., 323, 427-433. #9248

  180. Delmastro, P., Meola, A., Monaci, P., Cortese, R., & Galfre, G. (1997) Immunogenicity of filamentous phage displaying peptide mimotopes after oral administration. Vaccine, 15, 1276-1285. #10458

  181. Demirev, P.A., & Zubarev, R.A. (1997) Probing combinatorial library diversity by mass spectrometry. Anal. Chem., 69, 2893-2900. #9432

  182. Dente, L., Vetriani, C., Zucconi, A., Pelicci, G., Lanfrancone, L., Pelicci, P.G., & Cesareni, G. (1997) Modified phage peptide libraries as a tool to study specificity of phosphorylation and recognition of tyrosine containing peptides. J. Mol. Biol., 269, 694-703. #9509

  183. Dev, S. (1997) Ethnotherapeutics and modern drug development: The potential of ayurveda [review]. Curr. Sci., 73, 909-928. #10157

  184. Devlin, J.P. (1997) Chemical diversity and genetic equity: Synthetic and naturally derived compounds. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 3-48). Marcel Dekker,Inc., New York. #8988

  185. Devlin, J.P. (1997) Microcollection of plants for biochemical profiling. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 49-76). Marcel Dekker,Inc., New York. #8989

  186. Devlin, J.P. (1997) Data retrieval,handling and integration: Introduction. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 549-550). Marcel Dekker,Inc., New York. #9020

  187. Devlin, J.P. (1997) High Throughput Screening: The Discovery of Bioactive Substances. Marcel Dekker,Inc., New York. ISBN 0824700678 #8987

  188. DeWitt, S.H. & Czarnik, A.W. (1997) Summary. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 413-415). American Chemical Society, Washington,DC. #11706

  189. DeWitt, S.H. & Czarnik, A.W. (1997) Parallel organic synthesis using Parke-Davis Diversomer method. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 191-208). Marcel Dekker,Inc., New York. #8994

  190. DeWitt, S.H. & Czarnik, A.W. (1997) Parallel organic synthesis using Parke-Davis Diversomer technology. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 25-38). John Wiley & Sons,Inc., New York. #8351

  191. DeWitt, S.H. (1997) Automated synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 69-77). ESCOM, Leiden. #8618

  192. Dhalluin, C., Boutillon, C., Tartar, A., & Lippens, G. (1997) Magic angle spinning nuclear magnetic resonance in solid-phase peptide synthesis. J. Amer. Chem. Soc., 119, 10494-10500. #9602

  193. Dietzman, G.R. (1997) Data management and tracking for natural product programs. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 599-624). Marcel Dekker,Inc., New York. #9023

  194. Dietzman, G.R. (1997) The marine enviroment as a discovery resource. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 99-146). Marcel Dekker,Inc., New York. #8991

  195. Ditzel, H.J., Parren, P.W.H.I., Binley, J.M., Sodroski, J., Moore, J.P., Barbas, C.F., & Burton, D.R. (1997) Mapping the protein surface of human immunodeficiency virus type 1 gp120 using human monoclonal antibodies from phage display libraries. J. Mol. Biol., 267, 684-695. #9260

  196. Djaballah, H. (1997) Antigen processing by proteasomes: Insights into the molecular basis of crypticity. Mol. Biol. Rep., 24, 63-67. #9484

  197. Dmello, F., Partidos, C.D., Steward, M.W., & Howard, C.R. (1997) Definition of the primary structure of hepatitis B virus (HBV) pre-s hepatocyte binding domain using random peptide libraries. Virology, 237, 319-326. #10159

  198. Dolezalova, H., Vojtesek, B., & Kovarik, J. (1997) Epitope analysis of the human p53 tumour suppressor protein. Folia Biologica (Praha), 43, 49-51. #8399

  199. Dolle, R.E. (1997) Discovery of enzyme inhibitors through combinatorial chemistry. Mol. Diversity, 2, 223-236. #8870

  200. Domling, A., Richter, W., & Ugi, I. (1997) Combinatorial generation of nucleobase libraries by MCR. Nucleosides Nucleotides, 16, 1753-1756. #10160

  201. Donzel, A., Carmona, J. & Corkan, L.A. (1997) Perspectives on scheduling. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 525-548). Marcel Dekker,Inc., New York. #9019

  202. Dooley, C.T., Spaeth, C.G., Berzetei-Gurske, I.P., Craymer, K., Adapa, I.D., Brandt, S.R., Houghten, R.A., & Toll, L. (1997) Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J. Pharmacol. Exp. Ther., 283, 735-741. #10565

  203. Dorner, B., Ostresh, J.M., Blondelle, S.E., Dooley, C.T. & Houghten, R.A. (1997) Peptidomimetic synthetic combinatorial libraries. In Anonymous, Advances in Amino Acid Mimetics and Peptidomimetics. (pp. 109-125). JAI Press, Inc., #11629

  204. Dorsam, H., Rohrbach, P., Kurschner, T., Kipriyanov, S., Renner, S., Braunagel, M., Welschof, M., & Little, M. (1997) Antibodies to steroids from a small human naive IgM library. FEBS Lett., 414, 7-13. #10088

  205. Downs, G.M., & Barnard, J.M. (1997) Techniques for generating descriptive fingerprints in combinatorial libraries. Journal of Chemical Information and Computer Sciences, 37, 59-61. #8272

  206. Dreef-Tromp, C.M., Willems, H.A.M., Westerduin, P., van Veelen, P., & van Boeckel, C.A.A. (1997) Polymer-supported solution synthesis of heparan sulphate-like oligomers. Bioorg. Med. Chem. Lett., 7, 1175-1180. #10030

  207. Drewry, D.H., Gerritz, S.W., & Linn, J.A. (1997) Solid-phase synthesis of trisubstituted guanidines. Tetrahedron Lett., 38, 3377-3380. #8812

  208. Drouillat, B., Kellam, B., Dekany, G., Starr, M.S., & Toth, I. (1997) Solid phase synthesis of C-terminal carbohydrate modified enkephalins. Bioorg. Med. Chem. Lett., 7, 2247-2250. #9986

  209. Drouot, C., Enjalbal, C., Fulcrand, P., Martinez, J., & Aubagnac, J.L. (1997) Tof-SIMS analysis of polymer bound Fmoc-protected peptides. Tetrahedron Lett., 38, 2455-2458. #8779

  210. Dunayevskiy, Y.M., Lai, J.J., Quinn, C., Talley, F., & Vouros, P. (1997) Mass spectrometric identifications of ligands selected from combinatorial libraries using gel filtration. Rapid Commun. Mass Spectrom., 11, 1178-1184. #9524

  211. Dybwad, A., Forre, O., & Sioud, M. (1997) Probing for cerebrospinal fluid antibody specificities by a panel of random peptide libraries. Autoimmunity, 25, 85-89. #9263

  212. Eaton, B.E. (1997) The joys of in vitro selection: Chemically dressing oligonucleotides to satiate protein targets. Curr. Opin. Chem. Biol., 1, 10-16. #8710

  213. Eaton, B.E., Gold, L., Hicke, B.J., Janjic, N., Jucker, F.M., Sebesta, D.P., Tarasow, T.M., Willis, M.C., & Zichi, D.A. (1997) Post-SELEX combinatorial optimization of aptamers. Bioorg. Med. Chem., 5, 1087-1096. #9333

  214. Eckard, P., Delzer, J., Emling, F., Guhl, S., Janocha, R., Market, C., Paul, G., Seega, J., and Wernet, W. Integrated drug discovery: Thriving on organizational and technological improvements. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.233 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8307

  215. Ede, N.J., & Bray, A.M. (1997) A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the Multipin(TM) method. Tetrahedron Lett., 38, 7119-7122. #9579

  216. Edwards, M.G. (1997) Combinatorial chemistry alliances in the 1990s: Review of deal structures. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 314-320). ESCOM, Leiden. #8631

  217. Egner, B.J., & Bradley, M. (1997) Analytical techniques for solid-phase organic and combinatorial synthesis. Drug Disc. Today, 2, 102-109. #8656

  218. Egner, B.J., & Bradley, M. (1997) Monitoring the solid phase synthesis of analogues of lysobactin and the katanosins using in situ Maldi-Tof MS. Tetrahedron, 53, 14021-14030. #10166

  219. Egner, B.J., Rana, S., Smith, H., Bouloc, N., Frey, J., Brocklesby, W.S., & Bradley, M. (1997) Tagging in combinatorial chemistry: The use of colored and fluorescent beads. Chem. Commun., 735-736. #8727

  220. Eichler, J., & Houghten, R.A. (1997) Synthesis of cyclic disulfide peptides: Comparison of oxidation methods. Protein Peptide Lett., 4, 157-164. #11603

  221. Eisinger, D.P., & Trumpower, B.L. (1997) Long-inverse PCR to generate regional peptide libraries by codon mutagenesis. BioTechniques, 22, 250-252,254. #8398

  222. Eliseev, A.V., & Nelen, M.I. (1997) Use of molecular recognition to drive chemical evolution .1. Controlling the composition of an equilibrating mixture of simple arginine receptors. J. Amer. Chem. Soc., 119, 1147-1148. #8228

  223. Ellman, J., Stoddard, B., & Wells, J. (1997) Combinatorial thinking in chemistry and biology. Proc. Natl. Acad. Sci. USA, 94, 2779-2782. #9264

  224. Epton, R. (1997) Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. Mayflower Scientific Limited, Birmingham. ISBN 0952701111 #8773

  225. Esser, C.K., Kevin, N.J., Yates, N.A., & Chapman, K.T. (1997) Solid-phase synthesis of a N-carboxyalkyl tripeptide combinatorial library. Bioorg. Med. Chem. Lett., 7, 2639-2644. #9624

  226. Evans, D.M., & Herman, L.W. (1997) Identification of peptide ligands specific for the sugar-binding site of concanavalin A by screening a synthetic peptide combinatorial library. J. Biomol. Screen., 2, 225-233. #10168

  227. Fack, F., Hugle-Dorr, B., Song, D., Queitsch, I., Petersen, G., & Bautz, E.K. (1997) Epitope mapping by phage display: Random versus gene-fragment libraries. J. Immunol. Method, 206, 43-52. #10071

  228. Fagnola, M.C., Candiani, I., Visentin, G., Cabri, W., Zarini, F., Mongelli, N., & Bedeschi, A. (1997) Solid-phase synthesis of indoles using the palladium-catalyzed coupling of alkynes with iodoaniline derivatives. Tetrahedron Lett., 38, 2307-2310. #8775

  229. Falorni, M., Giacomelli, G., Nieddu, F., & Taddei, M. (1997) A new diketopiperazine tetra-carboxylic acid as template for the homogeneous phase synthesis of chemical libraries. Tetrahedron Lett., 38, 4663-4666. #8875

  230. Fancelli, D., Fagnola, M.C., Severino, D., & Bedeschi, A. (1997) Solid phase synthesis of 2-substituted benzofurans via the palladium-catalyzed heteroannulation of acetylenes. Tetrahedron Lett., 38, 2311-2314. #8776

  231. Farrar, J., Portolano, S., Willcox, N., Vincent, A., Jacobson, L., Newsomdavis, J., Rapoport, B., & McLachlan, S.M. (1997) Diverse fab specific for acetylcholine receptor epitopes from a myasthenia gravis thymus combinatorial library. Int. Immunol., 9, 1311-1318. #10170

  232. Fathi, R., Patel, R., & Cook, A.F. (1997) Phosphorus-based combinatorial libraries: Use of amino acid derivatives as synthons. Mol. Diversity, 2, 125-134. #8527

  233. Fauchere, J.L., Henlin, J.M., & Boutin, J.A. (1997) Peptide and nonpeptide lead discovery using robotically synthesized soluble libraries. Can. J. Physiol. Pharmacol., 75, 683-689. #9367

  234. Fauchere, J.L., Henlin, J.M., & Boutin, J.A. (1997) Combinatorial chemistry: State-of -art, analytical needs and future evolutions [Review] [French]. Analusis, 25, 97-101. #9534

  235. Fedorov, A.A., Almo, S.C., Valenta, R., & Ball, T. (1997) X-Ray crystal structures of birch pollen profilin and Phl p 2. Int. Arch. Allergy Immunol., 113, 109-113. #9982

  236. Feiglin, M. N. and Russell, B. J. A "component" based approach to laboratory automation. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.245 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8308

  237. Felder, E.R. & Poppinger, D. (1997) Combinatorial compound libraries for enhanced drug discovery approaches. In B. Testa & U.A. Meyer (Eds.), Advances in Drug Discovery. (pp. 111-199). Academic Press, London. #9545

  238. Felder, S. Strategies for automated microplate synthesis of combinatorial libraries. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.124 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8292

  239. Ferry, G., Boutin, J.A., Atassi, G., Fauchere, J.L., & Tucker, G.C. (1997) Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide libraries. Mol. Diversity, 2, 135-146. #8224

  240. Fields, G.B., & Colowick, S.P. (1997) Solid-Phase Peptide Synthesis. Academic Press, San Diego. ISBN 0121821900 #9830

  241. Finnerm, R., Pedrollo, E., Fisch, I., Wieslander, J., Marks, J.D., Lockwood, C.M., & Ouwehand, W.H. (1997) Human autoimmune anti-proteinase 3 scFv from a phage display library. Clin. Exp. Immunol., 107, 269-281. #8431

  242. Fitch, W.L. (1997) Analytical methods for the quality control of combinatorial libraries. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 59-68). ESCOM, Leiden. #8617

  243. Fitch, W.L., Szardenings, A.K., & Fujinari, E.M. (1997) Chemiluminescent nitrogen detection for HPLC: An important new tool in organic analytical chemistry. Tetrahedron Lett., 38, 1689-1692. #8459

  244. Fitzpatrick, L.J., & Rivero, R.A. (1997) Solid phase synthesis of substituted aminosulfonyl ureas using a sulfonyl carbamate linker. Tetrahedron Lett., 38, 7479-7482. #9567

  245. Flouzat, C., Marguerite, F., Croizet, F., Percebois, M., Monteil, A., & Combourieu, M. (1997) Solid-phase synthesis of "head-to-side chain" cyclic tripeptides using allyl deprotection. Tetrahedron Lett., 38, 1191-1194. #8390

  246. Floyd, C., Lewis, C., Patel, S., and Whittaker, M. The automated synthesis of organic compounds. Some newcomers have some success. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.51 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8270

  247. Flurer, C.L. (1997) Analysis of antibiotics by capillary electrophoresis [review]. Electrophoresis, 18, 2427-2437. #10175

  248. Flynn, D.L., Crich, J.Z., Devraj, R.V., Hockerman, S.L., Parlow, J.J., South, M.S., & Woodard, S. (1997) Chemical library purification strategies based on principles of complementary molecular reactivity and molecular recognition. J. Amer. Chem. Soc., 119, 4874-4881. #9091

  249. Fodor, S.P.A. (1997) Massively parallel biochemical assays. Lab. Automat. New., 2, 50-51. #9965

  250. Fraley, M.E., & Rubino, R.S. (1997) Two methods for the preparation of 2-cyclohexenones from resin-bound 1,3-cyclohexanedione. Tetrahedron Lett., 38, 3365-3368. #8810

  251. Frank, R. (1997) Multiple peptide synthesis with SPOT technique. In I. Lefkovits (Ed.), Immunology Methods Manual. (pp. 783-795). Academic Press, San Diego. #9739

  252. Frank, R. (1997) Principles of simultaneous synthesis of multiple peptides. In I. Lefkovits (Ed.), Immunology Methods Manual. (pp. 777-781). Academic Press, San Diego. #9740

  253. Fuchs, M.A., & Buta, C. (1997) The role of peptide modules in protein evolution. Biophys. Chem., 66, 203-210. #10177

  254. Fujisao, S., Nishimura, Y., & Matsushita, S. (1997) Evaluation of peptide-HLA binding by an enzyme-linked assay and its application to the detailed peptide motifs for HLA-DR9 (DRB1*0901). J. Immunol. Method, 201, 157-163. #8377

  255. Fukase, K. (1997) Combinatorial chemistry [japanese]. J. Syn. Org. Chem. Jpn., 55, 474-479. #9108

  256. Fukase, K., Egusa, K., Nakai, Y., & Kusumoto, S. (1997) Novel oxidatively removable protecting groups and linkers for solid-phase synthesis of oligosaccharides. Mol. Diversity, 2, 182-188. #8865

  257. Fukuyama, T., Cheung, M., Jow, C.K., Hidai, Y., & Kan, T. (1997) 2,4-Dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines. Tetrahedron Lett., 38, 5831-5834. #9310

  258. Furth, P.S., Reitman, M.S., Gentles, R., & Cook, A.F. (1997) Solid-phase synthesis of novel amino-ether derivatives. Tetrahedron Lett., 38, 6643-6646. #9546

  259. Gaillard, Y., & Pepin, G. (1997) Use of high-performance liquid chromatography with photodiode-array UV detection for the creation of a 600-compound library. Application to forensic toxicology. J. Chromatogr. A, 763, 149-163. #9354

  260. Gallop, M.A., & Fitch, W.L. (1997) New methods for analyzing compounds on polymeric supports. Curr. Opin. Chem. Biol., 1, 94-100. #8753

  261. Gani, D., Akhtar, M., Kroll, F.E., Smith, C.F., & Stones, D. (1997) Permutational organic synthesis in addressable microreactors (POSAMT): An efficient, inexpensive and versatile solid-phase protocol for the preparation of libraries of compounds on the 0.01 to 1.0 millimole (or larger) scale. Tetrahedron Lett., 38, 8577-8580. #9580

  262. Gao, C.S., Lin, C.H., Lo, C.H.L., Mao, S., Wirsching, P., Lerner, R.A., & Janda, K.D. (1997) Making chemistry selectable by linking it to infectivity. Proc. Natl. Acad. Sci. USA, 94, 11777-11782. #9884

  263. Garcia-Echeverria, C. (1997) A base labile handle for solid phase organic chemistry. Tetrahedron Lett., 38, 8933-8934. #9860

  264. Gargano, N., & Cattaneo, A. (1997) Inhibition of murine leukaemia virus retrotranscription by the intracellular expression of a phage-derived anti-reverse transcriptase antibody fragment. J. Gen. Virol., 78, 2591-2599. #10184

  265. Garigipati, R.S. (1997) Reagents for combinatorial organic synthesis: Preparation and uses of Rink-chloride. Tetrahedron Lett., 38, 6807-6810. #9547

  266. Gaynor, B., Putterman, C., Valadon, P., Spatz, L., Scharff, M.D., & Diamond, B. (1997) Peptide inhibition of glomerular deposition of an anti-DNA antibody. Proc. Natl. Acad. Sci. USA, 94, 1955-1960. #9292

  267. Gayo, L.M., & Suto, M.J. (1997) Ion-exchange resins for solution phase parallel synthesis of chemical libraries. Tetrahedron Lett., 38, 513-516. #8742

  268. Gennari, C., Nestler, H.P., Piarulli, U., & Salom, B. (1997) Combinatorial libraries: Studies in molecular recognition and the quest for new catalysts. Liebigs Ann. Chem., 637-647. #8665

  269. Georgiou, G., Stathopoulos, C., Daugherty, P.S., Nayak, A.R., Iverson, B.L., & Curtiss, R.I. (1997) Display of heterologous proteins on the surface of microorganisms: From the screening of combinatorial libraries to live recombinant vaccines. Nat. Biotech., 15, 29-34. #8255

  270. Gershoni, J.M., Stern, B., & Denisova, G. (1997) Combinatorial libraries, epitope structure and the prediction of protein conformations. Immunol. Today, 18, 108-110. #8371

  271. Gervay, J., Flaherty, T.M., & Nguyen, C. (1997) Solution phase synthesis of (1--5)-amide linked sugar amino acid dimers derived from sialic acids. Tetrahedron Lett., 38, 1493-1496. #8860

  272. Geyer, C.R., & Sen, D. (1997) Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme. Chem. Biol., 4, 579-593. #9980

  273. Gho, Y.S., Lee, J.E., Oh, K.S., Bae, D.G., & Chae, C.B. (1997) Development of antiangiogenin peptide using a phage-displayed peptide library. Cancer Res., 57, 3733-3740. #10067

  274. Giegel, D. ICE, the ICE family and inhibitor screening. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.2.3.1 #8881

  275. Giger, R. (1997) Combinatorial chemistry at lead finding. Chimia, 51, 819-819. #10188

  276. Gillet, V.J., Willett, P., & Bradshaw, J. (1997) The effectiveness of reactant pools for generating structurally-diverse combinatorial libraries. Journal of Chemical Information and Computer Sciences, 37, 731-740. #9529

  277. Girdwood, J.A., & Shute, R.E. (1997) Solid-phase synthesis of tri-functionalised, alpha-substituted carbamoylmethyl-homocysteine compounds, their release from the resin and subsequent intramolecular cyclisation to give novel 1,3,3-trisubstituted succinimides. Chem. Commun., 2307-2308. #10189

  278. Glaser, V. (1997) Conflicts brewing as phage display gets complex [news]. Nat. Biotech., 15, 506-506. #10472

  279. Gobbi, A., Poppinger, D., & Rohde, B. (1997) Developing an in-house system to support combinatorial chemistry. Perspect. Drug Disc. Design, 7-8, 131-158. #10729

  280. Gold, L., Brown, D., He, Y., Shtatland, T., Singer, B.S., & Wu, Y. (1997) From oligonucleotide shapes to genomic SELEX: Novel biological regulatory loops. Proc. Natl. Acad. Sci. USA, 94, 59-64. #9338

  281. Gold, L., & Alper, J. (1997) Drug discovery: Keeping pace with genomics through combinatorial chemistry. Nat. Biotech., 15, 297-297. #9271

  282. Good, A.C., & Lewis, R.A. (1997) New methodology for profiling combinatorial libraries and screening sets: Cleaning up the design process with HARPick. J. Med. Chem., 40, 3926-3936. #9882

  283. Goodman, B., Boymel, J., Johnson, C., Governski, B., Ross-Kramer, J., Van Ausdall, D., Jones, T., and Marshall, W. S. Automation in the oligonucleotide synthesis lab. The workstation approach. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.125 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8293

  284. Goodman, B. A., Bjergarde, K., and Boymel, J. L. Developing a high speed synthesis paradigm the work station approach. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.142 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8296

  285. Gopalsamy, A., & Pallai, P.V. (1997) Combinatorial synthesis of heterocycles: Solid phase synthesis of 2-arylquinoline-4-carboxylic acid derivatives. Tetrahedron Lett., 38, 907-910. #8406

  286. Gordeev, M.F., Gordon, E.M., & Patel, D.V. (1997) Solid-phase synthesis of beta-sultams. J. Org. Chem., 62, 8177-8181. #9625

  287. Gordeev, M.F., Hui, H.C., Gordon, E.M., & Patel, D.V. (1997) A general and efficient solid phase synthesis of quinazoline-2,4-diones. Tetrahedron Lett., 38, 1729-1732. #8458

  288. Gordon, E.M., Patel, D.V., Jacobs, J.W., Gordeev, M.F., & Zhou, J. (1997) Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery. Chimia, 51, 821-825. #9613

  289. Gosnell, P.A., Hilton, A.D., Anderson, L.M., Wilkins, L., & Janzen, W.P. (1997) Compound library management in high throughput screening. J. Biomol. Screen., 2, 99-102. #9842

  290. Gowravaram, M.R., & Gallop, M.A. (1997) "Traceless" solid-phase synthesis of furans via 1,3-dipolar cycloaddition reactions of isom nchones. Tetrahedron Lett., 38, 6973-6976. #9575

  291. Grabs, D., Slepnev, V.I., Zhou, S.Y., David, C., Lynch, M., Cantley, L.C., & Decamilli, P. (1997) The SH3 domain of amphiphysin binds the proline-rich domain of dynamin at a single site that defines a new SH3 binding consensus sequence. Journal of Biological Chemistry, 272, 13419-13425. #9220

  292. Gram, H., Schmitz, R., Zuber, J.F., & Baumann, G. (1997) Identification of phosphopeptide ligands for the Scr-homology 2 (SH2) domain of Grd2 by phage display. Eur. J. Biochem., 246, 633-637. #9518

  293. Gras-Masse, H., Boutillon, C., Diesis, E., Deprez, B., & Tartar, A. (1997) Confronting the degeneracy of convergent combinatorial immumogens, or mixotopes, with the specificity of recognition of the target sequences. Vaccine, 15, 1568-1578. #10196

  294. Graus, Y.F., de Baets, M.H., van Breda Vriesman, P.J., & Burton, D.R. (1997) Anti-acetylcholine receptor Fab fragments isolated from thymus-derived phage display libraries from myastenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. Immunol. Lett., 57, 59-62. #10087

  295. Graus, Y.F., Debaets, M.H., Parren, P.W.H.I., Berrihaknin, S., Wokke, J., Vriesman, P.J.V., & Burton, D.R. (1997) Human anti-nicotinic acetylcholine receptor recombinant fab fragments isolated from thymus-derived phage display libraries from myasthenia gravis patients reflect predominant specificities in serum and block the action of pathogenic serum antibodies. Journal of Immunology, 158, 1919-1929. #8411

  296. Gravert, D.J., & Janda, K.D. (1997) Synthesis on soluble polymers: New reactions and the contruction of small molecules. Curr. Opin. Chem. Biol., 1, 107-113. #8765

  297. Gravert, D.J., & Janda, K.D. (1997) Organic synthesis on soluble polymer supports: Liquid-phase methodologies. Chem. Rev., 97, 489-510. #8569

  298. Gray, N.S., Kwon, S., & Schultz, P.G. (1997) Combinatorial synthesis of 2,9-substituted purines. Tetrahedron Lett., 38, 1161-1164. #8443

  299. Green, C. The creation of an integrated data handling system for automated organic synthesis. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.164 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8298

  300. Greisman, H.A., & Pabo, C.O. (1997) A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science, 275, 657-661. #10440

  301. Griffith, D.L., O'Donnell, M.J., Pottorf, R.S., Scott, W.L., & Porco, J.A.Jr. (1997) Tandem UPS: Sequential mono- and dialkylation of resin-bound glycine via automated synthesis. Tetrahedron Lett., 38, 8821-8824. #9697

  302. Grimm, C., Lund, E., & Dahlberg, J.E. (1997) In vivo selection of RNAs that localize in the nucleus. EMBO J., 16, 793-806. #8384

  303. Gu, H.D., Kim, D., & Baker, D. (1997) Contrasting roles for symmetrically disposed beta-turns in the folding of a small protein. J. Mol. Biol., 274, 588-596. #10198

  304. Guenoun, F., Zair, T., Lamaty, F., Pierrot, M., Lazaro, R., & Viallefont, P. (1997) Pyrrolidinopiperazinedione as chiral auxiliary and its use in asymmetric Mannich synthesis. Tetrahedron Lett., 30, 1563-1566. #8861

  305. Gutteridge, W.E. (1997) Designer drugs: Pipe-dreams or realities. Parasitology, 114, 145-151. #10201

  306. Haap, W.J., Metzger, J.W., Kempter, C., & Jung, G. (1997) Composition and purity of combinatorial aryl ether collections analyzed by electrospray mass spectrometry. Mol. Diversity, 3, 29-41. #10097

  307. Hajduk, P.J., Sheppard, G., Nettesheim, D.G., Olejniczak, E.T., Shuker, S.B., Meadows, R.P., Steinman, D.H., Carrera, G.M.Jr., Marcotte, P.A., Severin, J., Walter, K., Smith, H., Gubbins, E., Simmer, R., Holzman, T.F., Morgan, D.W., Davidsen, S.K., Summers, J.B., & Fesik, S.W. (1997) Discovery of potent nonpeptide inhibitors of stromelysin using SAR by NMR. J. Amer. Chem. Soc., 119, 5818-5827. #11406

  308. Hajduk, P.J., Meadows, R.P., & Fesik, S.W. (1997) Discovering high-affinity ligands for proteins. Science, 278, 497-499. #11405

  309. Hajduk, P.J., Olejniczak, E.T., & Fesik, S.W. (1997) One-dimensional relaxation- and diffusion-edited NMR methods for screening compounds that bind to macromolecules. J. Amer. Chem. Soc., 119, 12257-12261. #11409

  310. Hajduk, P.J., Dinges, J., Miknis, G.F., Merlock, M., Middleton, T., Kempf, D.J., Egan, D.A., Walter, K.A., Robins, T.S., Shuker, S.B., Holzman, T.F., & Fesik, S.W. (1997) NMR-based discovery of lead inhibitors that block DNA binding of the human Papillomavirus E2 protein. J. Med. Chem., 40, 3144-3150. #11408

  311. Hall, D.G., & Schultz, P.G. (1997) Synthesis of diverse ethoxyformacetal oligomers. Toward libraries of metal-coordinating unnatural biopolymers. Tetrahedron Lett., 38, 7825-7828. #9681

  312. Hall, S.E. (1997) Recent advances in solid-phase synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 30-40). ESCOM, Leiden. #8614

  313. Hall, S.E. (1997) The future of combinatorial chemistry as a drug discovery paradigm. Pharmaceut. Res., 14, 1104-1105. #9881

  314. Halm, C., Evarts, J., & Kurth, M.J. (1997) A new attachment/cleavage strategy: Polymer-bound allylic sulfones in a solid-phase route to trisubstituted olefins. Tetrahedron Lett., 38, 7709-7712. #9677

  315. Halm, K. A., Adkison, K. K., Berman, J., Shaffer, J. E., Tong, W. Q., Lee, F. W., and Unger, S. E. N-in-One dosing in the dog: LC/MC as a tool for higher throughput in vivo pharmacokinetic screening of drug discovery compound mixtures. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.4.3.1 #8886

  316. Hamy, F., Felder, E.R., Heizmann, G., Lazdins, J., Aboul-ela, F., Varani, G., Karn, J., & Klimkait, T. (1997) An inhibitor of the Tat/TAR RNA interaction that effectively suppresses HIV-1 replication. Proc. Natl. Acad. Sci. USA, 94, 3548-3553. #8591

  317. Hansson, L.O., Widersten, M., & Mannervik, B. (1997) Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions. Biochemistry, 36, 11252-11260. #10480

  318. Harada, K., Martin, S.S., Tan, R.Y., & Frankel, A.D. (1997) Molding a peptide into an RNA site by in vivo peptide evolution. Proc. Natl. Acad. Sci. USA, 94, 11887-11892. #10206

  319. Harada, T., Katada, J., Tachiki, A., Asari, T., Iijima, K., Uno, I., Ojima, I., & Hayashi, Y. (1997) Development of the new potent non-peptide gpIIb/IIIa antagonist NSL-95301 by utilizing combinatorial technique. Bioorg. Med. Chem. Lett., 7, 209-212. #8436

  320. Hardin, J.H. & Smietana, F.R. (1997) Automating combinatorial chemistry: Challenges and pitfalls. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 251-262). Marcel Dekker,Inc., New York. #8998

  321. Harper, K., Kerschbaumer, R.J., Ziegler, A., Macintosh, S.M., Cowan, G.H., Himmler, G., Mayo, M.A., & Torrance, L. (1997) A scFv-alkaline phosphatase fusion protein which detects potato leafroll luteovirus in plant extracts by ELISA. J. Virol. Meth., 63, 237-242. #8432

  322. Harper, S.J., Brown, T., Feehally, J., Pringle, J.H., Stewart, A.S., McKeen, C.M., & Bailey, E. (1997) A comparative study of digoxigenin, 2,4-dinitrophenyl, and alkaline phosphatase as deoxyoligonucleotide labels in non-radioisotopic in situ hybridisation. J. Clin. Pathol., 50, 686-690. #9942

  323. Harriman, G.C.B. (1997) Synthesis of small and medium sized 2,2-disubstituted lactams via the "intramolecular" three component Ugi reaction. Tetrahedron Lett., 38, 5591-5594. #9306

  324. Harris, S.L., Craig, L., Mehroke, J.S., Rashed, M., Zwick, M.B., Kenar, K., Toone, E.J., Greenspan, N., Auzanneau, F.I., Marinoalbernas, J.R., Pinto, B.M., & Scott, J.K. (1997) Exploring the basis of peptide-carbohydrate crossreactivity: Evidence for discrimination by peptides between closely related anti-carbohydrate antibodies. Proc. Natl. Acad. Sci. USA, 94, 2454-2459. #9283

  325. Harrison, W. (1997) The importance of automated sample management systems in realizing the potential of large compound libraries in drug discovery. J. Biomol. Screen., 2, 203-206. #10562

  326. Hasenknopf, B., Lehn, J.M., Boumediene, N., Dupontgervais, A., Vandorsselaer, A., Kneisel, B., & Fenske, D. (1997) Self-assembly of tetra- and hexanuclear circular helicates. J. Amer. Chem. Soc., 119, 10956-10962. #10209

  327. Haslanger, M. F. Technology and drug discovery: Accomplishment and projections. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.7.3.1 #8889

  328. Haubner, R., Finsinger, D., & Kessler, H. (1997) Stereoisomeric peptide libraries and peptidomimetics for designing selective inhibitors of the alpha(V)beta(3) integrin for a new cancer therapy. Angew. Chem. Int. Ed., 36, 1375-1389. #9403

  329. Hauske, J. (1997) Combinatorial chemistry: The promise fulfilled? In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 321-325). ESCOM, Leiden. #8632

  330. Hawkins, G.D., Cramer, C.J., & Truhlar, D.G. (1997) Parametrized model for aqueous free energies of solvation using geometry-dependent atomic surface tensions with implicit electrostatics. J. Phys. Chem. B, 101, 7147-7157. #10210

  331. Hayashi, Y., Harada, T., Katada, J., & Uno, I. (1997) Combinatorial chemical approaches as an efficient tool for discovering GPIIb/IIIa anatagonists. Drugs Future, 22, 1367-1373. #12121

  332. Heinonen, P., & Lonnberg, H. (1997) A novel solid support for derivatization and subsequent N-alkylation of secondary amines: Preparation of N-alkylated 5- and 6-alkoxy-1,2,3,4-tetrahydroisoquinolines via Mitsunobu reaction. Tetrahedron Lett., 38, 8569-8572. #9692

  333. Heiskanen, T., Lundkvist, A., Vaheri, A., & Lankinen, H. (1997) Phage-displayed peptide targeting on the Puumala hantavirus neutralization site. J. Virol., 71, 3879-3885. #9261

  334. Heizmann, G., & Eberle, A.N. (1997) Xanthines as a scaffold for molecular diversity. Mol. Diversity, 2, 171-174. #8531

  335. Hemmer, B., Fleckenstein, B.T., Vergelli, M., Jung, G., McFarland, H., Martin, R., & Wiesmuller, K.H. (1997) Identification of high potency microbial and self ligands for a human autoreactive class ii-restricted t cell clone. J. Exp. Med., 185, 1651-1659. #9237

  336. Hemmila, I. (1997) Time-resolved fluorometry: Advantages and potentials. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 361-376). Marcel Dekker,Inc., New York. #9006

  337. Hennecke, M., Kola, A., Baensch, M., Wrede, A., Klos, A., Bautsch, W., & Kohl, J. (1997) A selection system to study C5a-C5a-receptor interactions: Phage display of a novel C5a anaphylatoxin, Fos-C5a(Ala27). Gene, 184, 263-272. #8437

  338. Herman, L.W., Tarr, G., & Kates, S.A. (1997) Optimization of the synthesis of peptide combinatorial libraries using a one-pot method. Mol. Diversity, 2, 147-155. #9233

  339. Hiemstra, H.S., Duinkerken, G., Benckhuijsen, W.E., Amons, R., de Vries, R.R., Roep, B.O., & Drijfhout, J.W. (1997) The identification of CD4+ T cell epitopes with dedicated synthetic peptide libraries. Proc. Natl. Acad. Sci. USA, 94, 10313-10318. #10070

  340. Higgs, R.E., Bemis, K.G., Watson, I.A., & Wikel, J.H. (1997) Experimental designs for selecting molecules from large chemical databases. Journal of Chemical Information and Computer Sciences, 37, 861-870. #9844

  341. Higuchi, K., & et al. (1997) Cell display library for gene cloning of variable regions of human antibodies to hepatitis B surface antigen. J. Immunol. Method, 202, 193-204. #9351

  342. Hilberink, P., van Aelst, S., Vink, T. Q., van Gool, E., and Kaspersen, F. Automated organic chemical synthesis. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.93 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8287

  343. Hird, N.W., Irie, K., & Nagai, K. (1997) Solid phase synthesis of 2-aminobutadienes using a piperazine linker. Tetrahedron Lett., 38, 7111-7114. #9577

  344. Hodge, P. (1997) Polymer-supported organic reactions: What takes place in the beads? Chem. Soc. Rev., 26, 417-424. #10534

  345. Hoekstra, W.J., Greco, M.N., Yabut, S.C., Hulshizer, B.L., & Maryanoff, B.E. (1997) Solid-phase synthesis via N-terminal attachment to the 2-chlorotrityl resin. Tetrahedron Lett., 38, 2629-2632. #8783

  346. Hoeprich, P. D. Jr. New approaches to automated solid phase organic synthesis. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.6.2.1 #8888

  347. Hogan, J.C.Jr. (1997) Combinatorial chemistry in drug discovery. Nat. Biotech., 15, 328-330. #9272

  348. Holm, A., Ostergaard, S., Hodges, R.S., Husband, D. & Buus, S. (1997) Multiple peptide synthesis on resin. In I. Lefkovits (Ed.), Immunology Methods Manual. (pp. 847-851). Academic Press, San Diego. #9737

  349. Holmes, C.P. (1997) Model studies for new o-nitrobenzyl photolabile linkers: Substituent effects on the rates of photochemical cleavage. J. Org. Chem., 62, 2370-2380. #8655

  350. Holt, R.M., Newman, M.J., Pullen, F.S., Richards, D.S., & Swanson, A.G. (1997) High-performance liquid chromatography/NMR spectrometry/mass spectrometry: Further advances in hyphenated technology. J. Mass Spectrom., 32, 64-70. #9343

  351. Hong, S.S., Karayan, L., Tournier, J., Curiel, D.T., & Boulanger, P.A. (1997) Adenovirus type 5 fiber knob binds to MHC class I alpha2 domain at the surface of human epithelial and B lymphoblastoid cells. EMBO J., 16, 2294-2306. #10483

  352. Hoogenboom, H.R. (1997) Designing and optimizing library selection strategies for generating high-affinity antibodies. Trends Biotech., 15, 62-70. #8402

  353. Hop, C.E.C.A., & Bakhtiar, R. (1997) An introduction to electrospray ionization and matrix-assisted laser desorption/ionization mass spectrometry: Essential tools in a modern biotechnology environment [Review]. Biospectroscopy, 3, 259-280. #9448

  354. Horwell, D.C., Kneen, C.O., Pritchard, M.C., Ratcliffe, G.S., Roberts, E., Suman-Chauhan, N., Steiner, K., & Betche, H.J. (1997) Design and synthesis of a targeted set of aromatic amino acid derivatives for identification of new lead compounds. Bioorg. Med. Chem. Lett., 7, 1957-1962. #9985

  355. Hoshino, M., Degenkolb, P., & Curran, D.P. (1997) Palladium-catalyzed Stille couplings with fluorous tin reactants. J. Org. Chem., 62, 8341-8349. #10219

  356. Houghten, R.A. (1997) First Japanese conference on combinatorial chemistry and high throughput screening. Mol. Diversity, 2, 181-181. #9487

  357. Houston, J.G., & Banks, M. (1997) The chemical-biological interface: Developments in automated and miniaturised screening technology. Curr. Opin. Biotechnol., 8, 734-740. #10220

  358. Hruby, V.J. (1997) Prospects for peptidomimetic drug design. Drug Disc. Today, 2, 165-167. #9848

  359. Hruby, V.J., Ahn, J.M., & Liao, S. (1997) Synthesis of oligopeptide and peptidomimetic libraries. Curr. Opin. Chem. Biol., 1, 114-119. #8770

  360. Hsieh, H.P., Chen, S.T., & Wang, K.T. (1997) Microwave induced synthesis of 3,4-dihydro-2h-pyran-2-carboxaldehyde: A versatile linker for solid phase combinatorial library. J. Chin. Chem. Soc., 44, 597-600. #10222

  361. Hsieh, Y.F., Gordon, N., Regnier, F., Afeyan, N., Martin, S.A., & Vella, G.J. (1997) Multidimensional chromatography coupled with mass spectrometry for target-based screening. Mol. Diversity, 2, 189-196. #8866

  362. Huang, C.F., Wong, G.W., Ghildyal, N., Gurish, M.F., Sali, A., Matsumoto, R., Qiu, W.T., & Stevens, R.L. (1997) The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma. Journal of Biological Chemistry, 272, 31885-31893. #10223

  363. Huang, J., & Schreiber, S.L. (1997) A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanodroplets. Proc. Natl. Acad. Sci. USA, 94, 13396-13401. #10224

  364. Huang, Z.W., Li, S.N., & Korngold, R. (1997) Immunoglobulin superfamily proteins: Structure, mechanisms, and drug discovery. Biopolymers, 43, 367-382. #11148

  365. Hubbard, R.E. (1997) Can drugs be designed? Curr. Opin. Biotechnol., 8, 696-700. #11382

  366. Huc, I., & Lehn, J.M. (1997) Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly (Vol 94, Pg 2106, 1997). Proc. Natl. Acad. Sci. USA, 94, 8272-8272. #9452

  367. Huc, I., & Lehn, J.M. (1997) Virtual combinatorial libraries: Dynamic generation of molecular and supramolecular diversity by self-assembly. Proc. Natl. Acad. Sci. USA, 94, 2106-2110. #8571

  368. Hunt, A.C., Williams, S.C., Davis, P.J., & Badley, R.A. (1997) Epitope mapping of bovine alpha-lactalbumin using a random phage display peptide library. Biochem. Soc. Trans., 25, S160-S160. #9203

  369. Hutton, W. C. and Herman, B. Adding value to enterprise-wide research and development programs through automated NMR spectroscopy. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.375 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8324

  370. Iannolo, G., Minenkova, O., Gonfloni, S., Castagnoli, L., & Cesareni, G. (1997) Construction, exploitation and evolution of a new peptide library displayed at high density by fusion to the major coat protein of filamentous phage. Biol. Chem. Hoppe-Seyler, 378, 517-521. #9499

  371. Iba, Y., & Kurosawa, Y. (1997) Comparison of strategies for the construction of libraries of artificial antibodies. Immunol. Cell Biol., 75, 217-221. #10080

  372. Iba, Y., Ito, W., & Kurosawa, Y. (1997) Expression vectors for the introduction of highly diverged sequences into the six complementarity-determining regions of an antibody. Gene, 194, 35-46. #10478

  373. Jacobsson, K., Jonsson, H., Lindmark, H., Guss, B., Lindberg, M., & Frykberg, L. (1997) Shot-gun phage display mapping of two streptococcal cell-surface proteins. Microbiol. Res., 152, 121-8. #10455

  374. James, I.W. (1997) Recent publications in solid-phase chemistry: Part 1. Mol. Diversity, 2, 175-180. #8532

  375. James, I.W. (1997) A compendium of solid-phase chemistry publications. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 326-344). ESCOM, Leiden. #8633

  376. James, M., Man, N.T., Edwards, Y.H., & Morris, G.E. (1997) The molecular basis for cross-reaction of an anti-dystrophin antibody with alpha-actinin. BBA-Mol. Basis Dis., 1360, 169-176. #9253

  377. Janda, K.D., Lo, L.C., Lo, C.H.L., Sim, M.M., Wang, R., Wong, C.H., & Lerner, R.A. (1997) Chemical selection for catalysis in combinatorial antibody libraries. Science, 275, 945-948. #8456

  378. Janniere, L., Bidnenko, V., McGovern, S., & Ehrlich, S.D. (1997) Replication terminus for DNA polymerase I during initiation of pAM beta 1 replication: Role of the plasmid-encoded resolution system. Mol. Microbiol., 23, 525-535. #8433

  379. Jaume, J.C., Guo, J., Kakinuma, A., Rapoport, B., & McLachlan, S.M. (1997) The epitopic fingerprint of thyroid peroxidase specific Fab isolated from a patients thyroid gland by the combinatorial library approach resembles that of autoantibodies in the donors serum. Clin. Immunol. Immunopathol., 84, 150-157. #9391

  380. Jelinek, R., Valente, A.P., Valentine, K.G., & Opella, S.J. (1997) Two-dimensional NMR spectroscopy of peptides on beads. J. Magn. Resonance, 125, 185-187. #9150

  381. Jelinek, R., Terry, T.D., Gesell, J.J., Malik, P., Perham, R.N., & Opella, S.J. (1997) NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein. J. Mol. Biol., 266, 649-655. #10449

  382. Jespers, L., Jenne, S., Lasters, I., & Collen, D. (1997) Epitope mapping by negative selection of randomized antigen libraries displayed on filamentous phage. J. Mol. Biol., 269, 704-718. #9510

  383. Jhaveri, S.D., Hirao, I., Bell, S., Uphoff, K.W. & Ellington, A.D. (1997) Landscapes for molecular evolution: Lessons from in vitro selection experiments with nucleic acids. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 169-191). ESCOM, Leiden. #8623

  384. Joyce, G.F., Still, W.C., & Chapman, K.T. (1997) Combinatorial chemistry searching for a winning combination. Curr. Opin. Chem. Biol., 1, 3-4. #8708

  385. Jung, K.W., Zhou, X., & Janda, K.D. (1997) Development of new linkers for the formation of aliphatic C-H bonds on polymeric supports. Tetrahedron, 53, 6645-6652. #8847

  386. Kahne, D. (1997) Combinatorial approaches to carbohydrates. Curr. Opin. Chem. Biol., 1, 130-135. #8772

  387. Kajimoto, T., & Ida, Y. (1997) Glycotechnology: Synthesis of carbohydrates and carbohydrate mimetics [japanese]. J. Syn. Org. Chem. Jpn., 55, 393-401. #9107

  388. Kakinuma, A., Portolano, S., Chazenbalk, G., Rapoport, B., & McLachlan, S.M. (1997) Insight into screening immunoglobulin gene combinatorial libraries in a phage display vector: A tale of two antibodies. Autoimmunity, 25, 73-84. #9262

  389. Kaldor, S.W., & Siegel, M.G. (1997) Combinatorial chemistry using polymer-supported reagents. Curr. Opin. Chem. Biol., 1, 101-106. #8758

  390. Kantorowski, E.J., & Kurth, M.J. (1997) Dipolar cycloadditions in solid-phase organic synthesis (SPOS). Mol. Diversity, 2, 207-216. #8868

  391. Kast, P., & Hilvert, D. (1997) 3D structural information as a guide to protein engineering using genetic selection. Curr. Opin. Struct. Biol., 7, 470-479. #10450

  392. Katritzky, A.R., Toader, D., Watson, K., & Kiely, J.S. (1997) New synthesis of SASRIN(TM) resin. Tetrahedron Lett., 38, 7849-7850. #9687

  393. Katritzky, A.R., Xie, L., & Zhang, G. (1997) Synthesis of primary amines via nucleophilic addition of organometallic reagents to aldimines on solid support. Tetrahedron Lett., 38, 7011-7014. #9576

  394. Katz, B.A. (1997) Structural and mechanistic determinants of affinity and specificity of ligands discovered or engineered by phage display. Annu. Rev. Biophys. Biomol. Struc., 26, 27-45. #10476

  395. Kaur, S., Mcguire, L., Tang, D.Z., Dollinger, G., & Huebner, V. (1997) Affinity selection and mass spectrometry-based strategies to identify lead compounds in combinatorial libraries. J. Protein Chem., 16, 505-511. #9467

  396. Kawaide, H., & et al. (1997) Ent-kaurene synthase from the fungus phaesosphaeria sp. L487.Cdna isolation, characterization, and bifunctional diterpene cyclase in fungal gibberellin biosynthesis. Journal of Biological Chemistry, 272, 21706-21712. #9350

  397. Kay, B.K. & Ellington, A.D. (1997) Combinatorial biology and evolution: A perspective. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 93-94). ESCOM, Leiden. #8620

  398. Kay, C., Murray, P.J., Sandow, L., & Holmes, A.B. (1997) A novel, chemically robust, amine releasing linker. Tetrahedron Lett., 39, 6941-6944. #9549

  399. Keifer, P.A. (1997) High-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry. Drug Disc. Today, 2, 468-478. #9585

  400. Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J., & Hohne, W. (1997) Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity. Cell, 91, 811-820. #10240

  401. Kellam, B., Bycroft, B.W., & Chhabra, S.R. (1997) Solid phase applications of Dde and the analogue Nde: Synthesis of trypanothione disulphide. Tetrahedron Lett., 38, 4849-4852. #9042

  402. Kennedy, K.J., Lundquist, J.T.IV., Simandan, T.L., Beeson, C.C., & Dix, T.A. (1997) Asymmetric synthesis of non-natural homologues of lysine. Bioorg. Med. Chem. Lett., 7, 1937-1940. #9426

  403. Kennedy, R. M. ACID for the Tecan(TM): An automated combinatorial interface demonstration. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.155 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8297

  404. Keough, T., Lacey, M.P., Ketcha, M.M., Bateman, R.H., & Green, M.R. (1997) Orthogonal acceleration single-pass time-of-flight mass spectrometry for determination of the exact masses of product ions formed in tandem mass spectrometry experiments. Rapid Commun. Mass Spectrom., 11, 1702-1708. #10241

  405. Kerns, E. H., Volk, K. J., Hail, M. E., Whitney, J. L., Rourick, R. A., Klohr, S. E., and Lee, M. S. Recent applications of accelerated structure analysis protocols. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.324 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8320

  406. Kessler, H. (1997) Structure-activity relationships by NMR: A new procedure for drug discovery by a combinatorial-rational approach. Angew. Chem. Int. Ed., 36, 829-831. #12488

  407. Kibbey, C.E. (1997) Analytical tools for solution-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 199-248). American Chemical Society, Washington,DC. #11700

  408. Kibbey, C.E. (1997) An automated system for the purification of combinatorial libraries by preparative LC/MS. Lab. Robotics Automation, 9, 309-321. #10242

  409. Kibbey, C. E., Robertson, G. A., MacDonald, A., and DeWitt, S. H. An automated system for the purification of combinatorial libraries by semi-preparative HPLC. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.336 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8321

  410. Kick, E.K., Roe, D.C., Skillman, A.G., Liu, G.C., Ewing, T.J.A., Sun, Y.X., Kuntz, I.D., & Ellman, J.A. (1997) Structure-based design and combinatorial chemistry yield low nanomolar inhibitors of cathepsin d. Chem. Biol., 4, 297-307. #9205

  411. Kieber-Emmons, T., Murali, R., & Greene, M.I. (1997) Therapeutic peptides and peptidomimetics. Curr. Opin. Biotechnol., 8, 435-441. #10448

  412. Kiely, J.S. (1997) Techniques for mixture synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 6-18). ESCOM, Leiden. #8612

  413. Kiely, J.S., Hayes, T.K., Griffith, M.C. & Pei, Y. (1997) Synthesis tools for solid-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 99-122). American Chemical Society, Washington,DC. #11697

  414. Kiely, J.S., Dorner, B., Ostresh, J.M., Dooley, C. & Houghten, R.A. (1997) Rapidly expanding molecular diversity: Libraries from libraries. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 155-166). Marcel Dekker, Inc., New York. #8691

  415. Kienle, S., Wiesmuller, K.H., Brunjes, J., Metzger, J.W., & Jung, G. (1997) MS-PEP: A computer program for the interpretation of mass spectra of peptide libraries. Fresenius J. Anal. Chem., 359, 10-14. #10243

  416. Kim, J.M., & Roy, R. (1997) Oligomeric glycopeptidomimetics bearing the cancer related T(N)-antigen. Tetrahedron Lett., 38, 3487-3490. #8848

  417. Kim, S.W., Ahn, S.Y., Koh, J.S., Lee, J.H., Ro, S., & Cho, H.Y. (1997) Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step. Tetrahedron Lett., 38, 4603-4606. #8874

  418. Kimura, T., Kaburaki, H., Miyamoto, S., Katayama, J., & Watanabe, Y. (1997) Discovery of a novel thrombopoietin mimic agonist peptide. J. Biochem. Tokyo, 122, 1046-1051. #10245

  419. Kiselyov, A.S., & Armstrong, R.W. (1997) Solid support synthesis of tetrahydroquinolines via the Grieco three component condensation. Tetrahedron Lett., 38, 6163-6166. #9315

  420. Kleinkauf, H., & von Dohren, H. (1997) Applications of peptide synthetases in the synthesis of peptide analogues. Acta Biochim. Polon., 44, 839-847. #10246

  421. Klekota, B., Hammond, M.H., & Miller, B.L. (1997) Generation of novel DNA-binding compounds by selection and amplification from self-assembled combinatorial libraries. Tetrahedron Lett., 38, 8639-8642. #9695

  422. Knappik, A. Combinatorial biology: Methods for accessing novel biomolecules through the use of vast and efficiently created libraries. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.4.1.4 #8884

  423. Knauer, M.F., Hawley, S.B., & Knauer, D.J. (1997) Identification of a binding site in protease nexin I (PN1) required for the receptor mediated internalization of PN1-thrombin complexes. Journal of Biological Chemistry, 272, 12261-12264. #9230

  424. Kocis, P. (1997) Combinatorial chemistry and drug discovery. Editorial. Drugs Future, 22, 1005-1006. #9839

  425. Kolb, A.J. (1997) Automation and robotics: Introduction. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 457-460). Marcel Dekker,Inc., New York. #9013

  426. Kolb, A.J. (1997) Assay technologies and detection methods: Introduction. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 275-278). Marcel Dekker,Inc., New York. #9000

  427. Kolb, A.J., Burke, J.W. & Mathis, G. (1997) A homogenous, time-resolved fluorescence method for drug discovery. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 345-360). Marcel Dekker,Inc., New York. #9005

  428. Kolb, J.M., Yamanaka, G. & Manly, S.P. (1997) Adaptation of time-resolved fluorescence to homogenous screening formats. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 377-388). Marcel Dekker,Inc., New York. #9007

  429. Koltermann, A., & Kettling, U. (1997) Principles and methods of evolutionary biotechnology [review]. Biophys. Chem., 66, 159-177. #10249

  430. Konings, D.A.M., Wyatt, J.R., Ecker, D.J., & Freier, S.M. (1997) Strategies for rapid deconvolution of combinatorial libraries: Comparative evaluation using a model system. J. Med. Chem., 40, 4386-4395. #10250

  431. Kontermann, R.E., Martineau, P., Cummings, C.E., Karpas, A., Allen, D., Derbyshire, E., & Winter, G. (1997) Enzyme immunoassays using bispecific diabodies. Immunotechnology, 3, 137-144. #10474

  432. Kornau, H.C., & Seeburg, P.H. (1997) Partner selection by PDZ domains. Nat. Biotech., 15, 319-319. #10465

  433. Kramer, A., Keitel, T., Winkler, K., Stocklein, W., Hohne, W., & Schneider-Mergener, J. (1997) Molecular basis for the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody. Cell, 91, 799-809. #10251

  434. Krantz, A. (1997) Red cell-mediated therapy - opportunities and challenges. Blood Cell. Mol. Dis., 23, 58-68. #8375

  435. Krchnak, V., & Weichsel, A.S. (1997) Polymer-supported synthesis of diverse perhydro-1,4-diazepine-2,5-diones. Tetrahedron Lett., 38, 7299-7302. #6947 4337

  436. Krebber, A., Bornhauser, S., Burmester, J., Honegger, A., Willuda, J., Bosshard, H.R., & Pluckthun, A. (1997) Reliable cloning of functional antibody variable domains from hybridomas and spleen cell repertoires employing a reengineered phage display system. J. Immunol. Method, 201, 35-55. #8440

  437. Krebber, C., Spada, S., Desplancq, D., Krebber, A., Ge, L.M., & Pluckthun, A. (1997) Selectively-infective phage (SIP): A mechanistic dissection of a novel in vivo selection for protein-ligand interactions. J. Mol. Biol., 268, 607-618. #9215

  438. Kris, R. Strategies for integration of combinatorial chemistry synthesis and screening. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.123 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8291

  439. Kris, R.M., Willson, P., Josiah, S., Wildgoose, M., Yeoman, H., Krchnak, V., Baum, S. & Felder, S. (1997) Combi-chem high throughput screening for leads optimization. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 263-274). Marcel Dekker,Inc., New York. #8999

  440. Kruijtzer, J.A.W., Lefeber, D.J., & Liskamp, R.M.J. (1997) Approaches to the synthesis of ureapeptoid peptidomimetics. Tetrahedron Lett., 38, 5335-5338. #9053

  441. Kubik, M.F., Bell, C., Fitzwater, T., Watson, S.R., & Tasset, D.M. (1997) Isolation and characterization of 2'-fluoro-, 2'-amino-, and 2'-fluoro/amino modified RNA ligands to human IFN-gamma that inhibit receptor binding. Journal of Immunology, 159, 259-267. #9516

  442. Kubinyi, H. (1997) QSAR and 3D QSAR in drug design. 2. Applications and problems. Drug Disc. Today, 2, 538-546. #10253

  443. Kuhlmann, J. (1997) Drug research: From the idea to the product [review]. Int. J. Clin. Pharmacol. Ther., 35, 541-552. #10254

  444. Kulkarni, B.A., & Ganesan, A. (1997) Ion-exchange resins for combinatorial synthesis: 2,4-Pyrrolidinediones by Dieckmann condensation. Angew. Chem. Int. Ed., 36, 2454-2455. #10255

  445. Kunysz, E.A., Lukes, M. & Bonhaus, D.W. (1997) Bar-code technology and a centralized database: Key components in a radioligand binding program. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 483-492). Marcel Dekker,Inc., New York. #9016

  446. Kurth, M.J. (1997) Polymer supported synthesis of organic compounds and libraries. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 39-64). John Wiley & Sons,Inc., New York. #8352

  447. Kuvshinov, V.N., Razumov, I.A., Ivanisenko, V.A., Eroshkin, A.M., Mishin, V.P., Oreshkova, S.F., Loktev, V.B., Il'ichev, A.A., & Sandakhchiev, L.S. (1997) Localization of a group-specific, hemagglutinating epitope of alphavirus glycoprotein E2 using a phage peptide library. Dokl. Akad. Nauk, 352, 113-116. #10068

  448. Kuwabara, I., Maruyama, H., Mikawa, Y.G., Zuberi, R.I., Liu, F.T., & Maruyama, I.N. (1997) Efficient epitope mapping by bacteriophage lambda surface display. Nat. Biotech., 15, 74-78. #8256

  449. Lafaye, P., Choumet, V., Demangel, C., Bon, C., & Mazie, J.C. (1997) Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library. Immunotechnology, 3, 117-125. #10075

  450. Lage, H., & Dietel, M. (1997) Cloning and characterization of human cDNAs encoding a protein with high homology to rat intestinal development protein OCI-5. Gene, 188, 151-156. #12489

  451. Lajiness, M.S. (1997) Dissimilarity-based compound selection techniques [review]. Perspect. Drug Disc. Design, 7-8, 65-84. #10726

  452. Lam, K.S., Lebl, M., & Krchnak, V. (1997) The "one-bead one-compound" combinatorial library method. Chem. Rev., 97, 411-448. #6980 4444

  453. Lam, K.S., & Zhao, Z.G. (1997) Targeted therapy for lymphoma with peptides. Hematol. Oncol. Clin. N. Amer., 11, 1007. #10258

  454. Lam, K.S. (1997) Application of combinatorial library methods in cancer research and drug discovery. Anti-Cancer Drug. Des., 12, 145-167. #8597

  455. Lambert, P.H., Boutin, J.A., Bertin, S., Fauchere, J.L., & Volland, J.P. (1997) Evaluation of high performance liquid chromatography electrospray mass spectrometry with selected ion monitoring for the analysis of large synthetic combinatorial peptide libraries. Rapid Commun. Mass Spectrom., 11, 1971-1976. #10259

  456. Lauvrak, V., Brekke, O.H., Ihle, O., & Lindqvist, B.H. (1997) Identification and characterisation of C1q-binding phage displayed peptides. Biol. Chem. Hoppe-Seyler, 378, 1509-1519. #10260

  457. Lawrence, R.M., Biller, S.A., Fryszman, O.M., & Poss, M.A. (1997) Automated synthesis and purification of amides: Exploitation of automated solid phase extraction in organic synthesis. Synthesis-Stuttgart, 553-558. #9079

  458. Le Hetet, C., David, M., Carreaux, F., Carboni, B., & Sauleau, A. (1997) Synthesis of functionalized gamma- and delta-lactones via polymer-bound epoxides. Tetrahedron Lett., 38, 5153-5156. #9034

  459. Leach, M. (1997) Virtual molecules! Drug Disc. Today, 2, 39-40. #12287

  460. Leadlay, P.F. (1997) Combinatorial approaches to polyketide biosynthesis. Curr. Opin. Chem. Biol., 1, 162-168. #10013

  461. Lebl, M., & Krchnak, V. (1997) Synthetic peptide libraries. Methods Enzymol., 289, 336-392. #9998

  462. Lee, B.H. (1997) Solid-phase synthesis of cyclooctadepsipeptide PF1022A analogs using a cyclization-cleavage method with oxime resin. Tetrahedron Lett., 38, 757-760. #8230

  463. Lee, D.K.H., Wilkinson, E.T., Cheifetz, S. & De Grandis, S.A. (1997) Development of a gene expression-based screen using quantitative polymerase chain reaction. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 413-426). Marcel Dekker,Inc., New York. #9010

  464. Lee, J., Murray, W.V., & Rivero, R.A. (1997) Solid phase synthesis of 3,4-disubstituted-7-carbamoyl-1,2,3,4-tetrahydroquinoxalin-2-ones. J. Org. Chem., 62, 3874-3879. #9075

  465. Legay, F., Albientz, P. & Ridder, R. (1997) Bio-analytical applications of BIAcore, an optical biosensor. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 443-456). Marcel Dekker,Inc., New York. #9012

  466. Leland, B.A., Christie, B.D., Nourse, J.G., Grier, D.L., Carhart, R.E., Maffett, T., Welford, S.M., & Smith, D.H. (1997) Managing the combinatorial explosion. Journal of Chemical Information and Computer Sciences, 37, 62-70. #8273

  467. Lemmo, A.V., Fisher, J.T., Geysen, H.M., & Rose, D.J. (1997) Characterization of an inkjet chemical microdispenser for combinatorial library synthesis. Anal. Chem., 69, 543-551. #8268

  468. Lescrinier, T., Busson, R., Dewinter, H., Hendrix, C., Janssen, G., Pannecouque, C., Rozenski, J., Vanaerschot, A., & Herdewijn, P. (1997) Alpha-amino acids derived from ornithine as building blocks for peptide synthesis. J. Pept. Res., 49, 183-189. #9228

  469. Levitan, B. (1997) Models and search strategies for applied molecular evolution. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 95-152). ESCOM, Leiden. #8621

  470. Lewell, X.Q., & Smith, R. (1997) Drug-motif-based diverse monomer selection: Method and application in combinatorial chemistry. J. Mol. Graphics, 15, 43-48. #12490

  471. Lewis, R.A., Mason, J.S., & McLay, I.M. (1997) Similarity measures for rational set selection and analysis of combinatorial libraries: The Diverse Property-Derived (DPD) approach. Journal of Chemical Information and Computer Sciences, 37, 599-614. #8704

  472. Li, J., & Wang, P.G. (1997) Chemical and enzymatic synthesis of glycoconjugates. 2. High yielding regioselective synthesis of N-acetyllactosamine by use of recombinant thermophilic glycosidases library. Tetrahedron Lett., 38, 7967-7970. #9690

  473. Li, M. (1997) Use of a modified bacteriophage to probe the interactions between peptides and ion channel receptors in mammalian cells. Nat. Biotech., 15, 559-563. #9195

  474. Li, S.C., Zhou, S.Y., Vincent, S.J.F., Zwahlen, C., Wiley, S., Cantley, L., Kay, L.E., Formankay, J., & Pawson, T. (1997) High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a

  475. Gly-Pro-(P)Tyr motif. Proc. Natl. Acad. Sci. USA, 94, 7204-7209. #9476

  476. Li, W., & Yan, B. (1997) A direct comparison of the mixing efficiency in solid-phase organic synthesis by single bead IR and fluorescence spectroscopy. Tetrahedron Lett., 38, 6485-6488. #9322

  477. Li, W., Liu, G., & Yun, L. (1997) Small molecular chemical libraries generated through solid phase organic synthesis. Huaxue Jinzhan, 9, 239-252. #9635

  478. Liang, O.D., Rosenblatt, S., Chhatwal, G.S., & Preissner, K.T. (1997) Identification of novel heparin-binding domains of vitronectin. FEBS Lett., 407, 169-172. #10463

  479. Liang, R., Loebach, J., Horan, N., Ge, M., Thompson, C., Yan, L., & Kahne, D. (1997) Polyvalent binding to carbohydrates immobilized on an insoluble resin. Proc. Natl. Acad. Sci. USA, 94, 10554-10559. #9640

  480. Liang, R. (1997) Part I. Synthesis and conformational studies of o-glycopeptides. Part II. Parallel synthesis and screening of a solid phase carbohydrate library. Princeton University, Princeton,NJ,USA; 1292 p. #9657

  481. Lima, W.F., Brown-Driver, V., Fox, M., Hanecak, R., & Bruice, T.W. (1997) Combinatorial screening and rational optimization for hybridization to folded hepatitis C virus RNA of oligonucleotides with biological antisense activity. Journal of Biological Chemistry, 272, 626-638. #9339

  482. Lin, M.F., Shapiro, M.J., & Wareing, J.R. (1997) Screening mixtures by affinity NMR. J. Org. Chem., 62, 8930-8931. #10269

  483. Lin, M.F., Shapiro, M.J., & Wareing, J.R. (1997) Diffusion-edited NMR-affinity NMR for direct observation of molecular interactions. J. Amer. Chem. Soc., 119, 5249-5250. #9083

  484. Lindsey, J.S. (1997) Automated approaches to reaction optimization. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 309-326). American Chemical Society, Washington,DC. #11703

  485. Linn, H., & et al. (1997) Using molecular repertoires to identify high-affinity peptide ligands of the WW domain of human and mouse YAP. Biol. Chem. Hoppe-Seyler, 378, 531-537. #9361

  486. Lister, M. D. and Janzen, W. Management of a centralized high throughput screening facility. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.43 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8283

  487. Lloyd-Williams, P., Albericio, F., & Giralt, E. (1997) Chemical Approaches to the Synthesis of Peptides and Proteins. CRC Press, Boca Raton. ISBN 0849391423 #9305

  488. Lloyd, A.W. (1997) Combinatorial chemistry: Hydroxystilbene kinase inhibitor library. Drug Disc. Today, 2, 556-556. #10271

  489. Longman, R. (1997) Screening the screeners. Start-up, 14-22. #9603

  490. Longman, R. (1997) Combinatorial chemistry's challenge. Start-up, 28-34. #8863

  491. Loo, J.A. (1997) Mass spectrometry in the combinatorial chemistry revolution. Eur. Mass Spectrom., 3, 93-104. #9088

  492. Loo, J.A., Hu, P.F., Mcconnell, P., Mueller, W.T., Sawyer, T.K., & Thanabal, V. (1997) A study of Src SH2 domain protein-phosphopeptide binding interactions by electrospray ionization mass spectrometry. J. Amer. Soc. Mass Spectrom., 8, 234-243. #9182

  493. Lou, Q., Leftwich, M.E., Mckay, R.T., Salmon, S.E., Rychetsky, L., & Lam, K.S. (1997) Potent pseudosubstrate-based peptide inhibitors for p60(c-src) protein tyrosine kinase. Cancer Res., 57, 1877-1881. #9070

  494. Lowman, H.B. (1997) Bacteriophage display and discovery of peptide leads for drug development [review]. Annu. Rev. Biophys. Biomol. Struc., 26, 401-424. #9193

  495. Lutz, E.S.M., Irth, H., Tjaden, U.R., & Vandergreef, J. (1997) Biochemical detection for direct bead surface analysis. Anal. Chem., 69, 4878-4884. #10272

  496. MacAllan, D., Sohal, J., Walker, C., Hill, D., & Moore, M. (1997) Development of a novel TNF alpha ligand-receptor binding assay for screening NATCHEM libraries. J. Recept. Signal Transduct. Res., 17, 521-529. #10081

  497. Maclean, D., Schullek, J.R., Murphy, M.M., Ni, Z.J., Gordon, E.M., & Gallop, M.A. (1997) Encoded combinatorial chemistry: Synthesis and screening of a library of highly functionalized pyrrolidines. Proc. Natl. Acad. Sci. USA, 94, 2805-2810. #8572

  498. Maddalena, D.J., & Snowdon, G.M. (1997) Applications of genetic algorithms to drug design [review]. Exp. Opin. Ther. Patents, 7, 247-254. #9285

  499. Maehr, H., & Yang, R. (1997) Structure optimization of a leukotriene D(4) antagonist by combinatorial chemistry in solution. Bioorg. Med. Chem., 5, 493-496. #9222

  500. Maehr, H. (1997) Combinatorial chemistry in drug research from a new vantage point. Bioorg. Med. Chem., 5, 473-491. #9221

  501. Maehr, H., & Yang, R. (1997) Optimization of leukotriene D4 antagonist by combinatorial chemistry in solution. Bioorg. Med. Chem., 5, 493-496. #11036

  502. Magliani, W., Conti, S., De Bernardis, F., Gerloni, M., Bertolotti, D., Mozzoni, P., Cassone, A., & Polonelli, L. (1997) Therapeutic potential of antiidiotypic single chain antibodies with yeast killer toxin activity. Nat. Biotech., 15, 155-158. #8434

  503. Mahler, S.M., Marquis, C.P., Brown, G., Roberts, A., & Hoogenboom, H.R. (1997) Cloning and expression of human V-genes derived from phage display libraries as fully assembled human anti-TNF alpha monoclonal antibodies. Immunotechnology, 3, 31-43. #10077

  504. Maier, E., Meier-Ewert, S., Bancroft, D., & Lehrach, H. (1997) Automated array technologies for gene expression profiling. Drug Disc. Today, 2, 315-324. #9852

  505. Major, J. Challenges and opportunities in high throughput screening: Implications for new technologies. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.25 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8281

  506. Makara, G.M., & Marshall, G.R. (1997) A facile synthesis of 3-substituted pipecolic acids, chimeric amino acids. Tetrahedron Lett., 38, 5069-5072. #9031

  507. Manning, A. M. Transcriptional regulation of inflammatory genes: New targets for drug development. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.3.2.1 #8883

  508. Marasco, W.A. (1997) Intrabodies: Turning the humoral immune system outside in for intracellular immunization. Gene Ther., 4, 11-15. #8438

  509. Markham, P.N., Neyfakh, A.A., & LoGuidice, J. (1997) Broad ligand specificity of the transcriptional regulator of the Bacillus subtilis multidrug transporter Bmr. Biochem. Biophys. Res. Commun., 239, 269-272. #9954

  510. Markman, M., & Peereboom, D.M. (1997) From serendipity to design: The evolution of drug development in oncology. Cleveland Clin. J. Med., 64, 155-163. #9071

  511. Marsh, I.R., Smith, H.K., Leblanc, C., & Bradley, M. (1997) Synthetic methods for polyamine linkers and their application to combinatorial chemistry. Mol. Diversity, 2, 165-170. #8530

  512. Marti, R.E., Bleicher, K.H., & Bair, K.W. (1997) Solid phase synthesis of beta-peptides via Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones. Tetrahedron Lett., 38, 6145-6148. #9313

  513. Marti, R.E., Yan, B., & Jarosinski, M.A. (1997) Solid-phase synthesis via 5-oxazolidinones: Ring-opening reactions with amines and reaction monitoring by single-bead FT-IR microspectroscopy. J. Org. Chem., 62, 5615-5618. #9415

  514. Martin, Y.C. (1997) Challenges and prospects for computational aids to molecular diversity. Perspect. Drug Disc. Design, 7-8, 159-172. #10730

  515. Marx, M.A., Grillot, A.L., Louer, C.T., Beaver, K.A., & Bartlett, P.A. (1997) Synthetic design for combinatorial chemistry: Solution and polymer-supported synthesis of polycyclic lactams by intramolecular cyclization of azomethine ylides. J. Amer. Chem. Soc., 119, 6153-6167. #9486

  516. Marzari, R., Sblattero, D., Righi, M., & Bradbury, A. (1997) Extending filamentous phage host range by the grafting of a heterologous receptor binding domain. Gene, 185, 27-33. #8444

  517. Marzari, R., Edomi, P., Bhatnagar, R.K., Ahmad, S., Selvapandiyan, A., & Bradbury, A. (1997) Phage display of Bacillus thuringiensis CrylA(a) insecticidal toxin. FEBS Lett., 411, 27-31. #9459

  518. Marzinzik, A.L., & Felder, E.R. (1997) Combinatorial libraries on rigid scaffolds: Solid phase synthesis of variably substituted pyrazoles and isoxazoles. Molecules, 2, 17-30. #8570

  519. Mason, J.S., & Pickett, S.D. (1997) Partition-based selection [review]. Perspect. Drug Disc. Design, 7-8, 85-114. #10727

  520. Mata, E.G. (1997) Beta-lactams on solid support: Mild and efficient removal of penicillin derivatives from Merrifield resin using aluminum chloride. Tetrahedron Lett., 38, 6335-6338. #9319

  521. Matter, H. (1997) Selecting optimally diverse compounds from structure databases: A validation study of two-dimensional and three-dimensional molecular descriptors. J. Med. Chem., 40, 1219-1229. #9259

  522. Matthews, I.T.W. (1997) The use of combinatorial and automated methods is drug discovery. Proc. West. Pharmacol. Soc., 40, 121-125. #11421

  523. Matthews, J., & Rivero, R.A. (1997) Base-promoted solid-phase synthesis of substituted hydantoins and thiohydantoins. J. Org. Chem., 62, 6090-6092. #10284

  524. Mavingui, P., Flores, M., Romero, D., Martinez-Romero, E., & Palacios, R. (1997) Generation of rhizobium strains with improved symbiotic properties by random DNA amplification (RDA). Nat. Biotech., 15, 564-569. #9196

  525. Mayer, G., & Kohler, J.M. (1997) Micromechanical compartments for biotechnological applications: Fabrication and investigation of liquid evaporation. Sensor. Actuator. A-Phys., 60, 202-207. #10286

  526. Mayer, J.P., Lewis, G.S., Curtis, M.J., & Zhang, J. (1997) Solid phase synthesis of quinazolinones. Tetrahedron Lett., 38, 8445-8448. #9670

  527. McClurg, J. E. Future directions of outsourced bioanalytical services: The Bioanalytical business. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.400 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8328

  528. McClusky, G. A., Tobias, B., Short, R., DeJohn, D., McMacken, L., Faraianu, C., and Judge, B. Automation of structure analysis in pharmaceutical R&D. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.388 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8325

  529. Mcinerney, T.L., Mclain, L., Armstrong, S.J., & Dimmock, N.J. (1997) A human IgG1 (b12) specific for the CD4 binding site of HIV-1 neutralizes by inhibiting the virus fusion entry process, but b12 Fab neutralizes by inhibiting a postfusion event. Virology, 233, 313-326. #9493

  530. McIntosh, R.S., Asghar, M.S., Kemp, E.H., Watson, P.F., Gardas, A., Banga, J.P., & Weetman, A.P. (1997) Analysis of immunoglobulin g-kappa antithyroid peroxidase antibodies from different tissues in Hashimotos thyroiditis. Journal of Clinical Endocrinology and Metabolism, 82, 3818-3825. #10288

  531. McIntosh, R.S., Asghar, M.S., & Weetman, A.P. (1997) The antibody response in human autoimmune thyroid disease [review]. Clin. Sci., 92, 529-541. #9187

  532. McIntosh, R.S., & Weetman, A.P. (1997) Molecular analysis of the antibody response to thyroglobulin and thyroid peroxidase [Review]. Thyroid, 7, 471-487. #9463

  533. Meissner, A., Bloch, P., Humpfer, E., Spraul, M., & Sorensen, O.W. (1997) Reduction of inhomogeneous line broadening in two-dimensional high-resolution mas nmr spectra of molecules attached to swelled resins in solid-phase synthesis. J. Amer. Chem. Soc., 119, 1787-1788. #8396

  534. Meldal, M., & St.Hilaire, P.M. (1997) Synthetic methods of glycopeptide assembly, and biological analysis of glycopeptide products. Curr. Opin. Chem. Biol., 1, 552-563. #10529

  535. Meldal, M. (1997) Properties of solid supports. Methods Enzymol., 289, 83-104. #9929

  536. Meldal, M., Juliano, M.A., & Jansson, A.M. (1997) Azido acids in a novel method of solid-phase peptide synthesis. Tetrahedron Lett., 38, 2531-2534. #8781

  537. Mellor, G.W., Fogarty, S.J., Obrien, M.S., Congreve, M., Banks, M.N., Mills, K.M., Jefferies, B., & Houston, J.G. (1997) Searching for chemokine receptor binding antagonists by high throughput screening. J. Biomol. Screen., 2, 153-157. #10290

  538. Mellor, S.L., McGuire, C., & Chan, W.C. (1997) N-Fmoc-Aminooxy-2-chlorotrityl polystyrene resin: A facile solid-phase methodology for the synthesis of hydroxamic acids. Tetrahedron Lett., 38, 3311-3314. #8803

  539. Mellor, S.L., & Chan, W.C. (1997) 4-[2,4-Dimethoxyphenyl(N-fluoren-9-ylmethoxycarbonyl-N-alkylaminooxy)methyl]phenoxymethyl polystyrene: A multiple solid-phase approach to N-alkylhydroxamic acids. Chem. Commun., 2005-2006. #10493

  540. Mennuni, C., Santini, C., Lazzaro, D., Dotta, F., Farilla, L., Fierabracci, A., Bottazzo, G.F., Dimario, U., Cortese, R., & Luzzago, A. (1997) Identification of a novel type 1 diabetes-specific epitope by screening phage libraries with sera from pre-diabetic patients. J. Mol. Biol., 268, 599-606. #9214

  541. Merrifield, B. (1997) Concept and early development of solid-phase peptide synthesis. Methods Enzymol., 289, 3-13. #9932

  542. Meyer, B., Weimar, T., & Peters, T. (1997) Screening mixtures for biological activity by NMR. Eur. J. Biochem., 246, 705-709. #10467

  543. Miller, G.P., Posner, B.A., & Benkovic, S.J. (1997) Expanding the 43C9 class of catalytic antibodies using a chain-shuffling approach. Bioorg. Med. Chem., 5, 581-590. #10471

  544. Miller, S.C., & Scanlan, T.S. (1997) Site-selective N-methylation of peptides on solid support. J. Amer. Chem. Soc., 119, 2301-2302. #9552

  545. Milner, N., Mir, K.U., & Southern, E.M. (1997) Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nat. Biotech., 15, 537-541. #9335

  546. Mitscher, L. A. Exploitation of natural product leads through combinatorial methods. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.5.1.1 #8887

  547. Mjalli, A.M.M. (1997) Application of automated parallel synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 327-354). American Chemical Society, Washington,DC. #11704

  548. Mjalli, A.M.M. & Toyonaga, B.E. (1997) Rapid discovery and optimization of biologically active small molecules using automated synthesis methods. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 209-222). Marcel Dekker,Inc., New York. #8995

  549. Moore, G.J. (1997) "Hinge" peptide libraries in basic research and drug development: Application to breast cancer and multiple sclerosis. Drug Develop. Res., 42, 157-163. #11121

  550. Moos, W.H., Pavia, M.R., Kay, B.K., & Ellington, A.D. (1997) Annual Reports in Combinatorial Chemistry and Molecular Diversity. ESCOM, Leiden. ISBN 9072199235 #8634

  551. Moos, W.H. (1997) Introduction: Combinatorial chemistry approaches the next millenium. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 1-16). American Chemical Society, Washington,DC. #11694

  552. Moos, W. H. Drug discovery meets biotech: How automation enables the 'better-faster-cheaper' paradigm. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.1 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8279

  553. Moos, W.H. (1997) Informatics and related topics: A perspective. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 265-266). ESCOM, Leiden. #8626

  554. Muddiman, D.C., Bakhtiar, R., Hofstadler, S.A., & Smith, R.D. (1997) Matrix-assisted laser desorption/ionization mass spectrometry. Instrumentation and applications. J. Chem. Educ., 74, 1288-1292. #11475

  555. Mukhopadhyay, M., Bhatia, B., & Iqbal, J. (1997) Cobalt catalyzed multiple component condensation route to b-acetamido carbonyl compound libraries. Tetrahedron Lett., 38, 1083-1086. #12492

  556. Mulders, S.J.E., Brouwer, A.J., & Liskamp, R.M.J. (1997) Molecular diversity of novel amino acid based dendrimers. Tetrahedron Lett., 38, 3085-3088. #8791

  557. Muller, K. (1997) On the paradigm shift from rational to random design. Theochem-J. Mol. Struct., 398, 467-471. #10295

  558. Murray, C.W., Clark, D.E., Auton, T.R., Firth, M.A., Li, J., Sykes, R.A., Waszkowycz, B., Westhead, D.R., & Young, S.C. (1997) PRO-SELECT: Combining structure-based drug design and combinatorial chemistry for rapid lead discovery. 1. Technology. J. Comput. Aid. Molec. Design, 11, 193-207. #9269

  559. Muskal, S.M. (1997) Information management. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 357-397). American Chemical Society, Washington,DC. #11705

  560. Myers, C.R., Porgilsson, B., & Myers, J.M. (1997) Antibodies to a synthetic peptide that react with flavin-containing monooxygenase (HLFMO3) in human hepatic microsomes. J. Pharmacol. Toxicol. Method., 37, 61-66. #10468

  561. Myers, P.L., Greene, J.W., Saunders, J., & Teig, S.L. (1997) Rapid, reliable drug discovery. The efficiency provided by informative libraries facilitates the generation and optimization of drug candidates. Today's Chemist at Work, 6, 46-53. #9970

  562. Myers, P.L. (1997) Will combinatorial chemistry deliver real medicines? Curr. Opin. Biotechnol., 8, 701-707. #10061

  563. Nagaraj, R. (1997) Structure-function relationships and engineering of host-defense peptides. Curr. Sci., 72, 819-825. #9078

  564. Neary, C. The present and future of automation in drug discovery. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.1.1.1 #8879

  565. Nefzi, A., Ostresh, J.M., & Houghten, R.A. (1997) The current status of heterocyclic combinatorial libraries. Chem. Rev., 97, 449-472. #8567

  566. Nefzi, A., Ostresh, J.M., Meyer, J.P., & Houghten, R.A. (1997) Solid phase synthesis of heterocyclic compounds from linear peptides: Cyclic ureas and thioureas. Tetrahedron Lett., 38, 931-934. #8407

  567. Nefzi, A., Ostresh, J.M., & Houghten, R.A. (1997) Solid phase synthesis of 1,3,4,7-tetrasubstituted perhydro-1,4-diazepine-2,5-diones. Tetrahedron Lett., 38, 4943-4946. #9038

  568. Neidleman, S.L. (1997) Enzymes and microbes as a source of chemical diversity. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 77-98). Marcel Dekker,Inc., New York. #8990

  569. Neil, W., Weller, H. N., Lawrence, R. M., and Young, M. G. Adaptation of liquid handlers to the automation of combinatorial organic chemistry. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.107 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8288

  570. Neuville, L., & Zhu, J. (1997) Solution phase combinatorial synthesis of arylpiperazines. Tetrahedron Lett., 38, 4091-4094. #9050

  571. Ngu, K., & Patel, D.V. (1997) Preparation of acid-labile resins with halide linkers and their utility in solid phase organic synthesis. Tetrahedron Lett., 38, 973-976. #8660

  572. Nicholson, I.C., Lenton, K.A., Little, D.J., Decorso, T., Lee, F.T., Scott, A.M., Zola, H., & Hohmann, A.W. (1997) Construction and characterisation of a functional CD19 specific single chain Fv fragment for immunotherapy of B lineage leukaemia and lymphoma. Mol. Immunol., 34, 1157-1165. #11162

  573. Nicolaou, K.C., Winssinger, N., Pastor, J., Ninkovic, S., Sarabia, F., He, Y., Vourloumis, D., Yang, Z., Li, T., Giannakakou, P., & Hamel, E. (1997) Synthesis of epothilones A and B in solid and solution phase. [Erratum to document cited in CA127:4950]. Nature, 390, 100-100. #9618

  574. Nicolaou, K.C., Winssinger, N., Pastor, J., Ninkovic, S., Sarabia, F., He, Y., Vourloumis, D., Yang, Z., Li, T., Glannakakou, P., & Hamel, E. (1997) Synthesis of epothilones A and B in solid and solution phase. Nature, 387, 268-272. #8642

  575. Nicolaou, K.C., Vourloumis, D., Li, T.H., Pastor, J., Winssinger, N., He, Y., Ninkovic, S., Sarabia, F., Vallberg, H., Roschangar, F., King, N.P., Finlay, M.R., Giannakakou, P., Verdier-Pinard, P., & Hamel, E. (1997) Designed epothilones: Combinatorial synthesis, tubulin assembly properties, and cytotoxic action against taxol-resistant tumor cells. Angew. Chem. Int. Ed., 36, 2097-2103. #9620

  576. Nielsen, J., & Jensen, F.R. (1997) Solid-phase synthesis of small molecule libraries using double combinatorial chemistry. Tetrahedron Lett., 38, 2011-2014. #8457

  577. Nihira, S., Kotaki, H., and Nakano, A. High throughput screening through the use of robotics and high performance data handling system. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.259 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8309

  578. Nihira, S., Kotaki, H., & Nakano, A. (1997) High-throughput screening through the use of robotics and high-performance data handling system. Amer. Lab., 29, 15-18. #9855

  579. Nishikawa, K., Toker, A., Johannes, F.J., Songyang, Z., & Cantley, L.C. (1997) Determination of the specific substrate sequence motifs of protein kinase C isozymes. Journal of Biological Chemistry, 272, 952-960. #10100

  580. Nord, K., Gunneriusson, E., Ringdahl, J., Stahl, S., Uhlen, M., & Nygren, P.A. (1997) Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domaind. Nat. Biotech., 15, 772-777. #9446

  581. Nowick, J.S., & Insaf, S. (1997) The propensities of amino acids to form parallel beta-sheets. J. Amer. Chem. Soc., 119, 10903-10908. #10306

  582. Numao, N., Hirota, Y., Iwahori, A., Sasatsu, M., Kondo, I., Takao, K., & Kobayashi, S. (1997) Antibacterial activity of (+/-)6-benzyl-1-(3-carboxypropyl)indane: A possible way to identify leading novel anti-h-pylori agents. Biol. Pharm. Bull., 20, 1204-1207. #10307

  583. Nuss, J.M., Desai, M.C., Zuckermann, R.N., Singh, R., Renhowe, P.A., Goff, D.A., Chinn, J.P., Wang, L., Dorr, H., Brown, E.G., & Subramanian, S. (1997) Developing a general strategy for the solid supported synthesis of heterocycles: Applications to the generation of molecular diversity and drug discovery. Pure Appl. Chem., 69, 447-452. #9166

  584. Nygren, P.A., & Uhlen, M. (1997) Scaffolds for engineering novel binding sites in proteins. Curr. Opin. Struct. Biol., 7, 463-469. #9428

  585. Obrecht, D., Abrecht, C., Grieder, A., & Villalgordo, J.M. (1997) A novel and efficient approach for the combinatorial synthesis of structurally diverse pyrimidines on solid support. Helv. Chim. Acta, 80, 65-72. #8657

  586. Ogata, K., & Umeyama, H. (1997) Prediction of protein side-chain conformations by principal component analysis for fixed main-chain atoms. Protein Eng., 10, 353-359. #10473

  587. Oiso, M., Nishi, T., Ishikawa, T., Nishimura, Y., & Matsushita, S. (1997) Differential binding of peptides substituted at putative C-terminal anchor residue to HLA-DQ8 and DQ9 differing only at beta 57. Hum. Immunol., 52, 47-53. #10438

  588. Olejniczak, E.T., Hajduk, P.J., Marcotte, P.A., Nettesheim, D.G., Meadows, R.P., Edalji, R., Holzman, T.F., & Fesik, S.W. (1997) Stromelysin inhibitors designed from weakly bound fragments: Effects of linking and cooperativity. J. Amer. Chem. Soc., 119, 5828-5832. #11407

  589. Osborne, S.E., Matsumura, I., & Ellington, A.D. (1997) Aptamers as a therapeutic and diagnostic reagents: Problems and prospects. Curr. Opin. Chem. Biol., 1, 5-9. #8709

  590. Osborne, S.E., & Ellington, A.D. (1997) Nucleic acid selection and the challenge of combinatorial chemistry. Chem. Rev., 97, 349-370. #8564

  591. Ostergaard, S., & Holm, A. (1997) Synthesis and screening of an indexed motif-library containing non-proteinogenic amino acids. J. Peptide Sci., 3, 123-132. #8581

  592. Ostergaard, S., & Holm, A. (1997) Peptomers: A versatile approach for the preparation of diverse combinatorial peptidomimetic bead libraries. Mol. Diversity, 3, 17-27. #8209

  593. Ostresh, J.M., Dorner, B., Blondelle, S.E. & Houghten, R.A. (1997) Soluble combinatorial libraries of peptides, peptidomimetics, and organics: Fundamental tools for basic research and drug discovery. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 225-240). John Wiley & Sons,Inc., New York. #8360

  594. Pacholczyk, T., & Sweadner, K.J. (1997) Epitope and mimotope for an antibody to the Na,K-ATPase. Protein Sci., 6, 1537-1548. #9466

  595. Pagratis, N.C., Bell, C., Chang, Y.F., Jennings, S., Fitzwater, T., Jellinek, D., & Dang, C. (1997) Potent 2'-amino-, and 2'-fluoro-2'-deoxyribonucleotide RNA inhibitors of keratinocyte growth factor. Biotechnology, 15, 68-73. #12495

  596. Palmer, D.S., Dudani, A.K., Drouin, J., & Ganz, P.R. (1997) Identification of novel factor VIII inhibitor epitopes using synthetic peptide arrays. Vox Sanguinis, 72, 148-161. #10481

  597. Pan, S., Li, H., Hong, F., Yu, B., & Zhao, K. (1997) Glycosyl donors with phosphorimidate leaving groups for either alpha- or beta-glycosidation. Tetrahedron Lett., 38, 6139-6142. #9312

  598. Pan, T. (1997) Novel and variant ribozymes obtained through in vitro selection. Curr. Opin. Chem. Biol., 1, 17-25. #8711

  599. Panek, J.S., & Zhu, B. (1997) Asymmetric crotylation reactions on solid support: Synthesis of stereochemically well-defined polypropionate-like subunits. J. Amer. Chem. Soc., 119, 12022-12023. #10443

  600. Parhami-Seren, B., Keel, T., & Reed, G.L. (1997) Sequences of antigenic epitopes of streptokinase identified via random peptide libraries displayed on phage. J. Mol. Biol., 271, 333-341. #10089

  601. Park, J.Y., Kim, I.J., Lee, M.H., Seo, J.K., Suh, P.G., Cho, B.Y., Ryu, S.H., & Chae, C.B. (1997) Identification of the peptides that inhibit the stimulation of thyrotropin receptor by Graves' immunoglobulin G from peptide libraries. Endocrinology, 138, 617-626. #8247

  602. Park, S.H., & Raines, R.T. (1997) Green fluorescent protein as a signal for protein-protein interactions. Protein Sci., 6, 2344-2349. #10313

  603. Parker, H.M., & Hefford, M.A. (1997) A consensus residue analysis of loop and helix-capping residues in four-alpha-helical-bundle proteins. Protein Eng., 10, 487-496. #10453

  604. Parker, M.H., & Hefford, M.A. (1997) A consensus residue analysis of loop and helix-capping residues in four-alpha-helical-bundle proteins. Protein Eng., 10, 487-496. #10479

  605. Parlow, J.J., Mischke, D.A., & Woodard, S.S. (1997) Utility of complementary molecular reactivity and molecular recognition (CMR/R) technology and polymer-supported reagents in the solution-phase synthesis of heterocyclic carboxamides. J. Org. Chem., 62, 5908-5919. #9377

  606. Parlow, J.J., Naing, W., South, M.S., & Flynn, D.L. (1997) In situ chemical tagging: Tetrafluorophthalic anhydride as a "sequestration enabling reagent" (SER) in the purification of solution-phase combinatorial libraries. Tetrahedron Lett., 38, 7959-7962. #9689

  607. Parren, P.W.H.I., Gauduin, M.C., Koup, R.A., Poignard, P., Sattentau, Q.J., Fisicaro, P., & Burton, D.R. (1997) Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design (Vol 57, Pg 105, 1997). Immunol. Lett., 58, U:3 ff. #9407

  608. Parren, P.W.H.I., Gauduin, M.C., Koup, R.A., Poignard, P., Fisicaro, P., Burton, D.R., & Sattentau, Q.J. (1997) Relevance of the antibody response against human immunodeficiency virus type 1 envelope to vaccine design. Immunol. Lett., 57, 105-112. #9464

  609. Parrill, A. (1997) Recent advances in computer-aided drug design methods [review]. Exp. Opin. Ther. Patents, 7, 937-945. #10316

  610. Partidos, C.D., Chirinos-Rojas, C.L., & Steward, M.W. (1997) The potential of combinatorial peptide libraries for the identification of inhibitors of TNF-alpha mediated cytotoxicity in vitro. Immunol. Lett., 57, 113-116. #9465

  611. Patel, D.J. (1997) Structural analysis of nucleic acid aptamers. Curr. Opin. Chem. Biol., 1, 32-46. #8713

  612. Patel, D.V. (1997) Application of combinatorial technology to drug discovery. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 78-89). ESCOM, Leiden. #8619

  613. Paterson, I., & Scott, J.P. (1997) Polyketide library synthesis: Conformational control in extended polypropionates. Tetrahedron Lett., 38, 7445-7448. #9573

  614. Paterson, I., & Scott, J.P. (1997) Polyketide library synthesis: Iterative assembly of extended polypropionates using (R)- and (S)-1-(benzyloxy)-2-methylpentan-3-one. Tetrahedron Lett., 38, 7441-7444. #9572

  615. Patterson, D. and Peterson, J. R. The optimally diverse lead discovery library. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.4.2.1 #8885

  616. Patterson, D.E., Ferguson, A.M., Cramer, R.D., Garr, C.D., Underiner, T.L. & Peterson, J.R. (1997) Design of a diverse screening library. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 243-250). Marcel Dekker,Inc., New York. #8997

  617. Patwardhan, A.V., Goud, G.N., Koepsel, R.R., & Ataai, M.M. (1997) Selection of optimum affinity tags from a phage-displayed peptide library: Application to immobilized copper(ii) affinity chromatography. J. Chromatogr., 787, 91-100. #10317

  618. Pavia, M.R. (1997) Combinatorial chemistry: A perspective. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 3-5). ESCOM, Leiden. #8611

  619. Pavia, M.R. (1997) Compound sourcing:Chemically generated screening libraries - Introduction. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 147-154). Marcel Dekker,Inc., New York. #8992

  620. Pavia, M.R., Hollinshead, S.P., Meyers, H.V., & Hall, S.P. (1997) Identifying novel leads using combinatorial libraries: Issues and successes. Chimia, 51, 826-831. #10319

  621. Pearson, W.H., & Clark, R.B. (1997) Solid-phase synthesis of pyrrolidines via 2-azaallyl anion cycloadditions with alkenes. Tetrahedron Lett., 38, 7669-7672. #9675

  622. Pei, Y., Houghten, R.A., & Kiely, J.S. (1997) Synthesis of 4-amino-3,4-dihydro-2(1H)-quinolinones via beta-lactam intermediates on the solid-phase. Tetrahedron Lett., 38, 3349-3352. #8808

  623. Peletskaya, E.N., Glinsky, V.V., Glinsky, G.V., Deutscher, S.L., & Quinn, T.P. (1997) Characterization of peptides that bind the tumor-associated Thomsen-Friedenreich antigen selected from bacteriophage display libraries. J. Mol. Biol., 270, 374-384. #9450

  624. Pereira, S., Van Belle, P., Elder, D., Maruyama, H., Jacob, L., Sivanandham, M., Wallack, M., Siegel, D., & Herlyn, D. (1997) Combinatorial antibodies against human malignant melanoma. Hybridoma, 16, 11-16. #10076

  625. Peretz, D., Williamson, R.A., Matsunaga, Y., Serban, H., Pinilla, C., Bastidas, R.B., Rozenshteyn, R., James, T.L., Houghten, R.A., Cohen, F.E., Prusiner, S.B., & Burton, D.R. (1997) A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform. J. Mol. Biol., 273, 614-622. #10323

  626. Persic, L., Roberts, A., Wilton, J., Cattaneo, A., Bradbury, A., & Hoogenboom, H.R. (1997) An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene, 187, 9-18. #10082

  627. Persic, L., Righi, M., Roberts, A., Hoogenboom, H.R., Cattaneo, A., & Bradbury, A. (1997) Targeting vectors for intracellular immunisation. Gene, 187, 1-8. #10083

  628. Persidis, A. (1997) Combinatorial chemistry. Nat. Biotech., 15, 391-392. #9273

  629. Pezzuto, J.M. (1997) Plant-derived anticancer agents. Biochem. Pharmacol., 53, 121-133. #9923

  630. Phalipon, A., Folgori, A., Arondel, J., Sgaramella, G., Fortugno, P., Cortese, R., Sansonetti, P.J., & Felici, F. (1997) Induction of anti-carbohydrate antibodies by phage library: Selected peptide mimics. Eur. J. Immunol., 27, 2620-2625. #10325

  631. Phillips, J.G., Fadnis, L., & Williams, D.R. (1997) 1-[2'-(Trimethylsilyl)ethoxymethyl]-2-phenylsulfonylimidazole: A new reagent for the preparation of C-4 substituted imidazoles. Tetrahedron Lett., 38, 7835-7838. #9683

  632. Picardo, M. & Hughes, K.T. (1997) Scintillation proximity assays. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 307-316). Marcel Dekker,Inc., New York. #9002

  633. Piettre, S.R., & Baltzer, S. (1997) A new approach to the solid-phase Suzuki coupling reaction. Tetrahedron Lett., 38, 1197-1200. #8601

  634. Pigache, P. (1997) Cracking the combination. Pharmaceutical Visions, 17. #11473

  635. Pindur, U., & et al. (1997) An advancement in drug research: Rational drug design with combinatorial chemistry. Pharm. Unserer. Zeit., 26, 24-30. #9340

  636. Pindur, U. (1997) An advancement in drug research: Rational drug design with combinatorial chemistry. Pharm. Unserer. Zeit., 26, 112-112. #9892

  637. Pinilla, C., Appel, J.R. & Houghten, R.A. (1997) The generation of peptide combinatorial libraries using tea bag synthesis: Identification of B-cell epitopes. In I. Lefkovits (Ed.), Immunology Methods Manual. (pp. 837-845). Academic Press Limited, London. #8690

  638. Pirrung, M.C., Chau, J.H.L. & Chen, J. (1997) Indexed combinatorial libraries: Nonoligomeric chemical diversity for the discovery of novel enzyme inhibitors. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 191-206). John Wiley & Sons,Inc., New York. #8358

  639. Pirrung, M.C. (1997) Spatially addressable combinatorial libraries. Chem. Rev., 97, 473-488. #8568

  640. Piscopio, A.D., Miller, J.F., & Koch, K. (1997) Solid phase heterocyclic synthesis via ring closing metathesis: Traceless linking and cyclative cleavage through a carbon-carbon double bond. Tetrahedron Lett., 38, 7143-7146. #9558

  641. Pistillo, M.P., Hammer, J., Bono, E., Sinigaglia, F., Bottero, F., Gho, A., & Ferrara, G.B. (1997) A novel approach to human anti-hla mabs production: Use of phage display libraries. Hum. Immunol., 57, 19-26. #10327

  642. Pivonka, D.E., & Simpson, T.R. (1997) Tools for combinatorial chemistry: Real-time single-bead infrared analysis of a resin-bound photocleavage reaction. Anal. Chem., 69, 3851-3853. #10329

  643. Plaisant, P., Burioni, R., Manzin, A., Solforosi, L., Candela, M., Gabrielli, A., Fadda, G., & Clementi, M. (1997) Human monoclonal recombinant Fabs specific for HCV antigens obtained by repertoire cloning in phage display combinatorial vectors. Res. Virol., 148, 165-169. #9278

  644. Pluckthun, A., & Cortese, R. (1997) New developments in combinatorial libraries. Biol. Chem. Hoppe-Seyler, 378, 443-443. #9495

  645. Plunkett, M.J., & Ellman, J.A. (1997) Combinatorial chemistry and new drugs. Sci. Amer., 267, 68-73. #9067

  646. Plunkett, M.J., & Ellman, J.A. (1997) Germanium and silicon linking strategies for traceless solid-phase synthesis. J. Org. Chem., 62, 2885-2893. #8640

  647. Poloni, F., Castagna, M., Felici, F., & Cianfriglia, M. (1997) A new immunohistochemical methodology for the specific detection of MDR1-P-glycoprotein in human tissues based on phage-displayed peptides mimicking the MM4.17 epitope. Biol. Chem. Hoppe-Seyler, 378, 503-507. #9498

  648. Pomerantz, S.C., McCloskey, J.A., Tarasow, T.M., & Eaton, B.E. (1997) Deconvolution of combinatorial oligonucleotide libraries by electrospray ionization tandem mass spectrometry. J. Amer. Chem. Soc., 119, 3861-3867. #9129

  649. Pop, I.E., Deprez, B.P., & Tartar, A.L. (1997) Versatile acylation of N-nucleophiles using a new polymer-supported 1-hydroxybenzotriazole derivative. J. Org. Chem., 62, 2594-2603. #8761

  650. Porco, J.A.Jr., Deegan, T., Devonport, W., Gooding, O.W., Heisler, K., Labadie, J.W., Newcomb, B., Nguyen, C., van Eikeren, P., Wong, J., & Wright, P. (1997) Automated chemical synthesis: From resins to instruments. Mol. Diversity, 2, 197-206. #8867

  651. Prichard, R. (1997) Application of molecular biology in veterinary parasitology. Vet. Parasitol., 71, 155-175. #9896

  652. Prien, O., Rolfing, K., Thiel, M., & Kunzer, H. (1997) Combinatorial synthesis of C(2), C(3)-disubstituted 3-hydroxypropionamides utilizing Baylis-Hillman reactions on solid support. Synlett, 325-326. #9149

  653. Prinsen, C.F.M., Weghuis, D.O., Van Kessel, A.G., & Veerkamp, J.H. (1997) Identification of a human heart FABP pseudogene located on chromosome 13. Gene, 193, 245-251. #12497

  654. Proulx, C., Chartrand, P., Roy, V., Goldman, M., Decary, F., & Rinfret, A. (1997) Human monoclonal Fab fragments recovered from a combinatorial library bind specifically to the platelet HPA-1a alloantigen on glycoprotein IIb-IIIa. Vox Sanguinis, 72, 52-60. #8232

  655. Pruijn, G.J., Schoute, F., Thijssen, J.P., Smeenk, R.J., & van Venrooij, W.J. (1997) Mapping of SLE-specific Sm B cell epitopes using murine monoclonal antibodies. J. Autoimmun., 10, 127-136. #10484

  656. Pues, H., Weinhold, E., & Holz, B. (1997) Construction of a deletion library using a mixture of 5'-truncated primers for inverse PCR (IPCR). Nucl. Acid. Res., 25, 1303-1304. #9352

  657. Pulli, T., Koivunen, E., & Hyypia, T. (1997) Cell-surface interactions of echovirus 22. Journal of Biological Chemistry, 272, 21176-21180. #10332

  658. Punniyamurthy, T., & Iqbal, J. (1997) Polyaniline supported cobalt (II) salen catalyzed synthesis of pyrrolidine containing alpha-hydroxyamide core structures as inhibitors for HIV proteases. Tetrahedron Lett., 38, 4463-4466. #8856

  659. Purandare, A.V., & Natarajan, S. (1997) Synthesis of chiral alpha-substituted beta-hydroxy acid derivatives on solid support. Tetrahedron Lett., 38, 8777-8780. #9696

  660. Radau, G., & et al. (1997) Combinatorial chemistry as a pool for new drugs. Pharm. Unserer. Zeit., 26, 10-11. #9341

  661. Rader, C., & Barbas, C.F.I. (1997) Phage display of combinatorial antibody libraries [Review]. Curr. Opin. Biotechnol., 8, 503-508. #9442

  662. Radl, S. (1997) Use of combinatorial chemistry and technology in identification of novel bioactive compounds. Drugs Future, 22, 1375-1379. #10537

  663. Raju, B., & Kogan, T.P. (1997) Solid phase synthesis of sulfonamides using a carbamate linker. Tetrahedron Lett., 38, 3373-3376. #8811

  664. Raju, B., & Kogan, T.P. (1997) Use of halomethyl resins to immobilize amines: An efficient method for synthesis of sulfonamides and amides on a solid support. Tetrahedron Lett., 38, 4965-4968. #9040

  665. Rano, T.A., Timkey, T., Peterson, E.P., Rotonda, J., Nicholson, D.W., Becker, J.W., Chapman, K.T., & Thornberry, N.A. (1997) A combinatorial approach for determining protease specificities: Application to interleukin-1beta converting enzyme (ICE). Chem. Biol., 4, 149-155. #9284

  666. Rapp, W.E. (1997) Macrobeads as microreactors: New solid-phase synthesis methodology. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 65-94). John Wiley & Sons,Inc., New York. #8353

  667. Rasamoelisolo, M., Czerwinski, M., Bruneau, V., Lisowska, E., & Blanchard, D. (1997) Fine characterization of a series of new monoclonal antibodies directed against glycophorin A. Vox Sanguinis, 72, 185-191. #10482

  668. Ray, B. New approaches for material handling at Glaxo Wellcome. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.398 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8326

  669. Reason, D.C., Wagner, T.C., & Lucas, A.H. (1997) Human fab fragments specific for the Haemophilus influenzae b polysaccharide isolated from a bacteriophage combinatorial library use variable region gene combinations and express an idiotype that mirrors in vivo expression. Infec. Immunity, 65, 261-266. #8254

  670. Reed, J.D., Edwards, D.L., & Gonzalez, C.F. (1997) Synthetic peptide combinatorial libraries: A method for the identification of bioactive peptides against phytopathogenic fungi. Mol. Plant. Microbe Interaction, 10, 537-549. #9521

  671. Reese, G., Jeoung, B.J., Daul, C.B., & Lehrer, S.B. (1997) Characterization of recombinant shrimp allergen Pen a 1 (tropomyosin). Int. Arch. Allergy Immunol., 113, 240-242. #9250

  672. Reichman, M. & Harris, A.L. (1997) Practical high throughput screening. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 273-286). ESCOM, Leiden. #8628

  673. Reynolds, C.H. (1997) Molecular modelling in agrochemicals. Chem. Ind. -London, 592-595. #9394

  674. Rice, R.L., Rusnak, J.M., Yokokawa, F., Yokokawa, S., Messner, D.J., Boynton, A.L., Wipf, P., & Lazo, J.S. (1997) A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation. Biochemistry, 36, 15965-15974. #11245

  675. Rieger, K.J., Kaniak, A., Coppee, J.Y., Aljinovic, G., Baudinbaillieu, A., Orlowska, G., Gromadka, R., Groudinsky, O., Dirago, J.P., & Slonimski, P.P. (1997) Large-scale phenotypic analysis: The pilot project on yeast chromosome III. Yeast, 13, 1547-1562. #10719

  676. Rippel, G., Corstjens, H., Billiet, H.A., & Frank, J. (1997) Affinity capillary electrophoresis [review]. Electrophoresis, 18, 2175-2183. #10337

  677. Rivero, R.A., Greco, M.N. & Maryanoff, B.E. (1997) Equipment for the high-throughput organic synthesis of chemical libraries. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 281-307). American Chemical Society, Washington,DC. #11702

  678. Robertson, D. (1997) Combinatorial companies attune to pharma needs. Nat. Biotech., 15, 311-312. #9337

  679. Robinson, D.D., Barlow, T.W., & Richards, W.G. (1997) The utilization of reduced dimensional representations of molecular structure for rapid molecular similarity calculations. Journal of Chemical Information and Computer Sciences, 37, 943-950. #10338

  680. Rodebaugh, R., Fraser-Reid, B., & Geysen, H.M. (1997) A new o-nitrobenzyl photocleavable linker for solid phase synthesis. Tetrahedron Lett., 38, 7653-7656. #9673

  681. Rodebaugh, R., Joshi, S., Fraser-Reid, B., & Geysen, H.M. (1997) Polymer-supported oligosaccharides via N-pentenyl glycosides: Methodology for a carbohydrate library. J. Org. Chem., 62, 5660-5661. #9647

  682. Rojas, N.R.L., Kamtekar, S., Simons, C.T., Mclean, J.E., Vogel, K.M., Spiro, T.G., Farid, R.S., & Hecht, M.H. (1997) De novo heme proteins from designed combinatorial libraries. Protein Sci., 6, 2512-2524. #10343

  683. Rose, D., & Lemmo, T. (1997) Challenges in implementing high-density formats for high throughput screening. Lab. Automat. New., 2, 12-19. #9966

  684. Rosenblum, N.D., & Yager, T.D. (1997) Changing patterns of gene expression in developing mouse kidney, as probed by differential mRNA display combined with cDNA library screening. Kidney Int., 51, 920-925. #12498

  685. Rossen, K., Sager, J., & DiMichele, L.M. (1997) An efficient and versatile synthesis of piperazine-2-carboxamides. Tetrahedron Lett., 38, 3183-3186. #8795

  686. Rotheim, P. (1997) The "biochemotechnology" revolution. Chemtech, 27, 20-25. #9606

  687. Rothman, J.H., & Still, W.C. (1997) Peptide-binding antibiotics: A solid-phase assay for screening libraries of vancomycin mimics for selective d-Ala-d-Ala binding. Bioorg. Med. Chem. Lett., 7, 3159-3164. #10344

  688. Rothmund, M., Schutz, A., Brecht, A., Gauglitz, G., Berthel, G., & Grafe, D. (1997) Label free binding assay with spectroscopic detection for pharmaceutical screening. Fresenius J. Anal. Chem., 359, 15-22. #10345

  689. Rotman, D. (1997) Research: Combinatorial chemistry looks for new materials. Chemical Week, 159, 30-31. #10347

  690. Rotman, D. (1997) Combinatorial chemistry: Symyx finds a better phosphor. Chemical Week, 159, 57-57. #10346

  691. Rottlander, M., & Knochel, P. (1997) New multi-coupling benzylic zinc reagents for the preparation of flexible aromatic compounds. Tetrahedron Lett., 38, 1749-1752. #8859

  692. Roussel, P., Bradley, M., Matthews, I., & Kane, P. (1997) A linker for amidines in solid phase synthesis. Tetrahedron Lett., 38, 4861-4864. #9044

  693. Routburg, M., Swenson, R., Schmitt, B., Washington, A., Mueller, S., Hochlowski, J., Maslana, G., Minin, B., Matuszak, K., Searle, P., and Pan, J. Implementation of an automated purification/verification system. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.360 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8323

  694. Routledge, A., Abell, C., & Balasubramanian, S. (1997) An investigation into solid-phase radical chemistry: Synthesis of furan rings. Synlett, 61-62. #9555

  695. Routledge, A., Abell, C., & Balasubramanian, S. (1997) The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis. Tetrahedron Lett., 38, 1227-1230. #8392

  696. Rowan, S.J., & Sanders, J.K.M. (1997) Building thermodynamic combinatorial libraries of quinine macrocycles. Chem. Commun., 1407-1408. #9528

  697. Roy, S., Helmer, K.J., & Hecht, M.H. (1997) Detecting native-like properties in combinatorial libraries of de novo proteins. Folding and Design, 2, 89-92. #9246

  698. Rudge, D.A. (1997) The automation of solution phase synthetic chemistry using a XP Zymate laboratory robotic systems. Lab. Autom. Inf. Manage., 33, 81-86. #11425

  699. Rudiger, S., Germeroth, L., Schneider-Mergener, J., & Bukau, B. (1997) Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J., 16, 1501-1507. #9209

  700. Ruhland, B., Bombrun, A., & Gallop, M.A. (1997) Solid-phase synthesis of 4-arylazetidin-2-ones via Suzuki and Heck cross-coupling reactions. J. Org. Chem., 62, 7820-7826. #10350

  701. Ruzzene, M., Zhou, S.Y., Marin, O., Donelladeana, A., Brunati, A.M., Guerra, B., Agostinis, P., Cantley, L.C., & Pinna, L.A. (1997) Sequence specificity of C-terminal Src kinase (CSK): A comparison with Src-related kinases c-Fgr and Lyn. Eur. J. Biochem., 246, 433-439. #9186

  702. Sabesan, S. (1997) Synthesis of peptidosialosides and peptidosaccharides. Tetrahedron Lett., 38, 3127-3130. #8794

  703. Salemme, F.R., Spurlino, J., & Bone, R. (1997) Serendipity meets precision: The integration of structure-based drug design and combinatorial chemistry for efficient drug discovery. Structure, 5, 319-324. #9267

  704. Samson, I., Rozenski, J., Samyn, B., van Aerschot, A., van Beeumen, J., & Herdewijn, P. (1997) Screening a random pentapeptide library, composed of 14 D-amino acids, against the COOH-terminal sequence of fructose-1,6-bisphosphate aldolase from Trypanosoma brucei. Journal of Biological Chemistry, 272, 11378-11383. #9247

  705. Sanders, I., Allen, M.C., Matthews, I.M., & Campbell, M.M. (1997) Display of fixed residues on variable cyclic scaffolds: A novel approach to peptide combinatorial library synthesis. Bioorg. Med. Chem. Lett., 7, 2603-2606. #9989

  706. Sashar, S. & Mjalli, A.M.M. (1997) Techniques for single-compound synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 19-29). ESCOM, Leiden. #8613

  707. Sato, V. Introduction. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.1.0.1 #8878

  708. Saven, J.G., & Wolynes, P.G. (1997) Statistical mechanics of the combinatorial synthesis and analysis of folding macromolecules. J. Phys. Chem. B, 101, 8375-8389. #10353

  709. Scheirer, W. (1997) Reporter gene assay applications. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 401-412). Marcel Dekker,Inc., New York. #9009

  710. Schepens, J., Cuppen, E., Wieringa, B., & Hendriks, W. (1997) The neuronal nitric oxide synthase PDZ motif binds to -G(D,E)XV- asterisk carboxyterminal sequences. FEBS Lett., 409, 53-56. #9185

  711. Scheuerlarsen, C., Rosenbohm, C., Jorgensen, T.J.D., & Wengel, J. (1997) Introduction of a universal solid support for oligonucleotide synthesis. Nucleosides Nucleotides, 16, 67-80. #8366

  712. Schleyer, A., Meldal, M., Manat, R., Paulsen, H., & Bock, K. (1997) Direct solid-phase glycosylations of peptide templates on a novel PEG-based resin. Angew. Chem. Int. Ed., 36, 1976-1978. #9631

  713. Schneider, C.H. (1997) Peptides in Immunolgy. John Wiley & Sons, New York. ISBN 0471965901 #11586

  714. Schonfeld, E. (1997) Merck vs. the biotech industry: Which one is more potent? Fortune, 161-162. #8588

  715. Schow, S.R., Mackman, R.L., Blum, C.L., Brooks, E., Horsma, A.G., Joly, A., Kerwar, S.S., Lee, G., Shiffman, D., Nelson, M.G., Wang, X., Wick, M.M., Zhang, X., & Lum, R.T. (1997) Synthesis and actictivity of 2,6,9-trisubstituted purines. Bioorg. Med. Chem. Lett., 7, 2697-2702. #10035

  716. Schullek, J.R., Butler, J.H., Ni, Z.J., Chen, D., & Yuan, Z. (1997) A high-density screening format for encoded combinatorial libraries: Assay miniaturization and its application to enzymatic reactions. Anal. Biochem., 246, 20-29. #9294

  717. Schuster, P. (1997) Molecular evolutionary biology. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 153-168). ESCOM, Leiden. #8622

  718. Schuur, J., & Gasteiger, J. (1997) Infrared spectra simulation of substituted benzene derivatives on the basis of a 3D structure representation. Anal. Chem., 69, 2398-2405. #9511

  719. Scott, R.H., & Balasubramanian, S. (1997) Properties of fluorophores on solid phase resins: Implications for screening, encoding and reaction monitoring. Bioorg. Med. Chem. Lett., 7, 1567-1572. #9513

  720. Scott, W.L., Zhou, C., Fang, Z., & O'Donnell, M.J. (1997) The solid phase synthesis of alpha,alpha-disubstituted unnatural amino acids and peptides (di-UPS). Tetrahedron Lett., 38, 3695-3698. #8853

  721. Seitz, O., & Kunz, H. (1997) HYCRON, an allylic anchor for high-efficiency solid phase synthesis of protected peptides and glycopeptides. J. Org. Chem., 62, 813-826. #8389

  722. Seliger, H., Bader, R., Hinz, M., Rotte, B., Astriab, A., Markiewicz, M., & Markiewicz, W.T. (1997) Synthetic oligonucleotide combinatorial libraries: Tools for studying nucleic acid interactions. Nucleosides Nucleotides, 16, 703-710. #9421

  723. Selzer, P.M., Chen, X., Chan, V.J., Cheng, M., Kenyon, G.L., Kuntz, I.D., Sakanari, J.A., Cohen, F.E., & McKerrow, J.H. (1997) Leishmania major: Molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors. Exp. Parasitol., 87, 212-221. #9885

  724. Shapiro, M.J., Lin, M. & Yan, B. (1997) On-resin analysis in combinatorial chemistry. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 123-151). American Chemical Society, Washington,DC. #10017

  725. Shapiro, M.J., Chin, J., Marti, R.E., & Jarosinski, M.A. (1997) Enhanced resolution in MAS NMR for combinatorial chemistry. Tetrahedron Lett., 38, 1333-1336. #8378

  726. Shiba, K., Takahashi, Y., & Noda, T. (1997) Creation of libraries with long ORFs by polymerization of a microgene. Proc. Natl. Acad. Sci. USA, 94, 3805-3810. #9242

  727. Shibata, N., Baldwin, J.E., & Wood, M.E. (1997) Resin-bound peptide libraries showing specific metal ion binding. Bioorg. Med. Chem. Lett., 7, 413-416. #8376

  728. Shin, J.A. (1997) Specific DNA binding peptide-derivatized solid support. Bioorg. Med. Chem. Lett., 7, 2367-2372. #9987

  729. Shipps, G.W.Jr., Pryor, K.E., Xian, J., Skyler, D.A., Davidson, E.H., & Rebek, J.Jr. (1997) Synthesis and screening of small molecule libraries active in binding to DNA. Proc. Natl. Acad. Sci. USA, 94, 11833-11838. #10361

  730. Short, K.M., & Mjalli, A.M.M. (1997) A solid-phase combinatorial method for the synthesis of novel 5- and 6-membered ring lactams. Tetrahedron Lett., 38, 359-362. #8526

  731. Short, K.M., Ching, B.W., & Mjalli, A.M.M. (1997) Exploitation of the Ugi 4CC reaction: Preparation of small molecule combinatorial libraries via solid phase. Tetrahedron, 53, 6653-6679. #8635

  732. Shuker, A.J., Siegel, M.G., Matthews, D.P., & Weigel, L.O. (1997) The application of high-throughput synthesis and purification to the preparation of ethanolamines. Tetrahedron Lett., 38, 6149-6152. #9314

  733. Shumate, C., Beckey, S., Coassin, P., & Stylli, H. (1997) Ultra-High throughput screening. Lab. Automat. New., 2, 24-9. #9968

  734. Shuttleworth, S.J., Allin, S.M., & Sharma, P.K. (1997) Functionalised polymers: Recent developments and new applications in synthetic organic chemistry [review]. Synthesis-Stuttgart, 1217-1239. #10363

  735. Sibi, M.P., & Chandramouli, S.V. (1997) Intermolecular free radical reactions on solid support. Allylation of esters. Tetrahedron Lett., 38, 8929-8932. #9859

  736. Sibille, P., & Strosberg, A.D. (1997) A FIV epitope defined by a phage peptide library screened with a monoclonal anti-FIV antibody. Immunol. Lett., 59, 133-137. #10364

  737. Sibille, P., Ternynck, T., Nato, F., Buttin, G., Strosberg, D., & Avrameas, A. (1997) Mimotopes of polyreactive anti-DNA antibodies identified using phage-display peptide libraries. Eur. J. Immunol., 27, 1221-1228. #9219

  738. Siegel, M.G., Hahn, P.J., Dressman, B.A., Fritz, J.E., Grunwell, J.R., & Kaldor, S.W. (1997) Rapid purification of small molecule libraries by ion exchange chromatography. Tetrahedron Lett., 38, 3357-3360. #8764

  739. Sim, M.M., Lee, C.L., & Ganesan, A. (1997) Combinatorial synthesis of 2-thioxo-4-dihydropyrimidinones. J. Org. Chem., 62, 9358-9360. #12212

  740. Sim, M.M., & Ganesan, A. (1997) Solution-phase synthesis of a combinatorial thiohydantoin library. J. Org. Chem., 62, 3230-3235. #9103

  741. Singer, B.S., Shtatland, T., Brown, D., & Gold, L. (1997) Libraries for genomic SELEX. Nucl. Acid. Res., 25, 781-786. #12499

  742. Sittampalam, G.S., Kahl, S.D., & Janzen, W.P. (1997) High-throughput screening: Advances in assay technologies. Curr. Opin. Chem. Biol., 1, 384-391. #10365

  743. Slawomir, S., Friedlhajek, R., Siemann, U., Ebner, C., Scheiner, O., & Breiteneder, H. (1997) T cell receptor CDR3 sequences and recombinant T cell receptors. Int. Arch. Allergy Immunol., 113, 170-172. #9249

  744. Sloan, D.D., Barrett, R.W., Tate, E.H., & England, B.P. (1997) Expression of an epitope tagged human c5a receptor and antibody-mediated immobilization of detergent-solubilized receptor for drug discovery screening. Protein Express. Purif., 11, 119-124. #10366

  745. Slootstra, J.W., Kuperus, D., Pluckthun, A., & Meloen, R.H. (1997) Identification of new tag sequences with differential and selective recognition properties for the anti-FLAG monoclonal antibodies M1,M2, and M5. Mol. Diversity, 2, 156-164. #8529

  746. Smith, G.P., & Petrenko, V.A. (1997) Phage display. Chem. Rev., 97, 391-410. #8566

  747. Smith, J., & Anslyn, E.V. (1997) In vitro selection without intervening amplification. Angew. Chem. Int. Ed., 36, 1879-1881. #12500

  748. Smith, J., & Cooper, T. (1997) Combinatorial synthesis in medicinal chemistry: Implications in drug discovery and development. Epitheor. Klin. Farmacol. Farmakokinet. ,Int. Ed., 11, 104-107. #10531

  749. Smith, R.D., Bruce, J.E., Wu, Q.Y., & Lei, Q.P. (1997) New mass spectrometric methods for the study of noncovalent associations of biopolymers [review]. Chem. Soc. Rev., 26, 191-202. #9530

  750. Soehnge, H., Huang, X., Becker, M., Conover, D., & Stern, M. (1997) Cloning and sequencing of ribosomal protein L-27a and a gene similar to human GS1 in Drosophila. Gene, 185, 257-263. #12501

  751. Songyang, Z., Fanning, A.S., Fu, C., Xu, J., Marfatia, S.M., Chishti, A.H., Crompton, A., Chan, A.C., Anderson, J.M., & Cantley, L.C. (1997) Recognition of unique carboxyl-terminal motifs by distinct PDZ domains. Science, 275, 73-77. #10101

  752. Soth, M.J., & Nowick, J.S. (1997) Unnatural oligomers and unnatural oligomer libraries. Curr. Opin. Chem. Biol., 1, 120-129. #8771

  753. Spada, S., Krebber, C., & Pluckthun, A. (1997) Selectively infective phages (SIP). Biol. Chem. Hoppe-Seyler, 378, 445-456. #9496

  754. Spaller, M.R., Burger, M.T., Fardis, M., & Bartlett, P.A. (1997) Synthetic strategies in combinatorial chemistry. Curr. Opin. Chem. Biol., 1, 47-53. #8714

  755. Spatz, L., Iliev, A., Saenko, V., Jones, L., Irigoyen, M., Manheimerlory, A., Gaynor, B., Putterman, C., Bynoe, M., Kowal, C., Kuo, P., Newman, J., & Diamond, B. (1997) Studies on the structure, regulation, and pathogenic potential of anti-dsDNA antibodies [review]. Methods (Duluth), 11, 70-78. #10373

  756. Spellmeyer, D.C., Blaney, J.M. & Martin, E.M. (1997) Computational approaches to chemical libraries. In P.S. Charifson (Ed.), Practical Application of Computer-Aided Drug Design. (pp. 165-193). Marcel Dekker,Inc., New York. #8719

  757. Spencer, R.W. (1997) Diversity analysis in high throughput screening. J. Biomol. Screen., 2, 69-70. #9297

  758. Sportsman, J.R., Lee, S.K., Dilley, H. & Bukar, R. (1997) Fluorescence polarization. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 389-400). Marcel Dekker,Inc., New York. #9008

  759. Spurway, T.D., Morland, C., Cooper, A., Sumner, I., Hazlewood, G.P., O'Donnel, A.G., Pickersgill, R.W., & Gilbert, H.J. (1997) Calcium protects a mesophilic xylanase from proteinase inactivation and thermal unfolding. Journal of Biological Chemistry, 272, 17523-17530. #10469

  760. Stahl, S., & Uhlen, M. (1997) Bacterial surface display: Trends and progress. Trends Biotech., 15, 185-192. #9238

  761. Steinbeck, C., Berlin, K., & Richert, C. (1997) MASP: A program predicting mass spectra of combinatorial libraries. Journal of Chemical Information and Computer Sciences, 37, 449-457. #8705

  762. Steinberger, P., Kraft, D., & Valenta, R. (1997) Expression in Escherichia coli of human Ige antibody fragments with specificity for major timothy grass pollen allergens using the combinatorial library approach. Int. Arch. Allergy Immunol., 113, 258-259. #9251

  763. Stephensen, H., & Zaragoza, F. (1997) Resin-bound isothiocyanates and their synthetic equivalents as intermediates for the solid-phase synthesis of substituted thiophenes. J. Org. Chem., 62, 6096-6097. #9325

  764. Stern, B., Denisova, G., Buyaner, D., Raviv, D., & Gershoni, J.M. (1997) Helical epitopes determined by low-stringency antibody screening of a combinatorial peptide library. FASEB J., 11, 147-153. #8372

  765. Stricker, N.L., Christopherson, K.S., Yi, B.A., Schatz, P.J., Raab, R.W., Dawes, G., Bassett, D.E.Jr., Bredt, D.S., & Li, M. (1997) PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences. Nat. Biotech., 15, 336-342. #10466

  766. Studer, A., & Curran, D.P. (1997) A strategic alternative to solid phase synthesis: Preparation of a small isoxazoline library by "fluorous synthesis". Tetrahedron, 53, 6681-6696. #9117

  767. Studer, A., Hadida, S., Ferritto, R., Kim, S.Y., Jeger, P., Wipf, P., & Curran, D.P. (1997) Fluorous synthesis: A fluorous-phase strategy for improving separation efficiency in organic synthesis. Science, 275, 823-826. #8229

  768. Studer, A., Jeger, P., Wipf, P., & Curran, D.P. (1997) Fluorous synthesis: Fluorous protocols for the Ugi and Biginelli multicomponent condensations. J. Org. Chem., 62, 2917-2924. #9128

  769. Studt, T. (1997) Combinatorial chemistry successes create new process demands. R&D Mag., 39, 38-42. #10378

  770. Studt, T. (1997) Maturing combinatorial chemistry creates new technology base. R&D Mag., 39, 32-34. #9396

  771. Stump, M.D., Madison-Antenucci, S., Kokoska, R.J., & Steege, D.A. (1997) Filamentous phage IKe mRNAs conserve form and function despite divergence in regulatory elements. J. Mol. Biol., 266, 51-65. #8441

  772. Sucholeiki, I. (1997) Solid-phase methods in combinatorial chemistry. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 119-134). John Wiley & Sons,Inc., New York. #8355

  773. Sucholeiki, I. (1997) Selection of supports for solid-phase organic synthesis. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 41-49). ESCOM, Leiden. #8615

  774. Sugimoto, N., & Nakano, S. (1997) Sandwiching interaction of peptides with a porphyrin. Chem. Lett., 939-940. #10380

  775. Sun, X.D., Gao, C., Wang, J.S., & Xiang, X.D. (1997) Identification and optimization of advanced phosphors using combinatorial libraries. Appl. Phys. Lett., 70, 3353-3355. #9541

  776. Sunyaev, S., Kuznetsov, E., Rodchenkov, I., & Tumanyan, V. (1997) Protein sequence-structure compatibility criteria in terms of statistical hypothesis testing. Protein Eng., 10, 635-646. #10456

  777. Sutherlin, D.P., & Armstrong, R.W. (1997) Synthesis of 12 stereochemically and structurally diverse C-trisaccharides [Review]. J. Org. Chem., 62, 5267-5283. #9414

  778. Swali, V., Wells, N.J., Langley, G.J., & Bradley, M. (1997) Solid-phase dendrimer synthesis and the generation of super-high-loading resin beads for combinatorial chemistry. J. Org. Chem., 62, 4902-4903. #9301

  779. Swali, V., & Bradley, M. (1997) Analytical techniques for single bead analysis in combinatorial chemistry. Anal. Commun., 34, H:15-H:18. #10382

  780. Swann, P.G., Casanova, R.A., Desai, A., Frauenhoff, M.M., Urbancic, M., Slomczynska, U., Hopfinger, A.J., Le Breton, G.C., & Venton, D.L. (1997) Nonspecific protease-catalysed hydrolysis/synthesis of a mixture of peptides: Product diversity and ligand amplification by a molecular trap. Biopolymers (Pept. Sci. ), 40, 617-626. #8590

  781. Swayze, E.E. (1997) The solid phase synthesis of trisubstituted 1,4-diazabicyclo[4.3.0]nonan-2-one scaffolds: On bead monitoring of heterocycle forming reactions using (15)N NMR. Tetrahedron Lett., 38, 8643-8646. #9694

  782. Sylvain, C., Wagner, A., & Mioskowski, C. (1997) Ozone: A versatile reagent for solid phase synthesis. Tetrahedron Lett., 38, 1043-1044. #8409

  783. Szardenings, A.K., Burkoth, T.S., Lu, H.H., Tien, D.W., & Campbell, D.A. (1997) A simple procedure for the solid phase synthesis of diketopiperazine and diketomorpholine derivatives. Tetrahedron, 53, 6573-6593. #9113

  784. Szardenings, M., Tornroth, S., Mutulis, F., Muceniece, R., Keinanen, K., Kuusinen, A., & Wikberg, J.E. (1997) Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1. Journal of Biological Chemistry, 272, 27943-27948. #10384

  785. Szostak, J.W. (1997) Introduction: Combinatorial chemistry. Chem. Rev., 97, 347-348. #8563

  786. Tafi, R., Bandi, R., Prezzi, C., Mondelli, M.U., Cortese, R., Monaci, P., & Nicosia, A. (1997) Identification of HCV core mimotopes: Improved methods for the selection and use of disease-related phage-displayed peptides. Biol. Chem. Hoppe-Seyler, 378, 495-502. #9497

  787. Taki, T., Ishikawa, D., Hamasaki, H., & Handa, S. (1997) Preparation of peptides which mimic glycosphingolipids by using phage peptide library and their modulation on beta-galactosidase activity. FEBS Lett., 418, 219-223. #10386

  788. Tang, X.B., Dallaire, P., Hoyt, D.W., Sykes, B.D., O'Connor-McCourt, M., & Malcolm, B.A. (1997) Construction of transforming growth factor alpha (tgf-alpha) phage library and identification of high binders of epidermal growth factor receptor (egfr) by phage display. J. Biochem. Tokyo, 122, 686-690. #10387

  789. Tanha, J., Forsyth, G., Schorr, P., Crosby, W., & Lee, J.S. (1997) Sequence and structure specific antibodies from phage display libraries. Mol. Immunol., 34, 109-113. #10078

  790. Taylor, C.M. (1997) Strategies for combinatorial libraries of oligosaccharides. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 207-224). John Wiley & Sons,Inc., New York. #8359

  791. Taylor, E.W., Gibbons, J.A., & Braeckman, R.A. (1997) Intestinal absorption screening of mixtures from combinatorial libraries in the Caco-2 model. Pharmaceut. Res., 14, 572-577. #9216

  792. Taylor, L. C., Garr, C., Johnson, R. L., and Batt, J. Open access mass spectrometry in combinatorial chemistry. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.349 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8322

  793. Tchernychev, B., Cabilly, S., & Wilchek, M. (1997) The epitopes for natural polyreactive antibodies are rich in proline. Proc. Natl. Acad. Sci. USA, 94, 6335-6339. #9189

  794. Teerhuis, N.M., Hiemstra, H., & Speckamp, W.N. (1997) Synthesis of enantiopure (nor-)azatropanes via N-acylhydrazonium ion intermediates. Tetrahedron Lett., 38, 155-158. #8608

  795. Tegge, W., & Frank, R. (1997) Peptide synthesis on Sepharose(TM) beads. J. Pept. Res., 49, 355-362. #8702

  796. Tempest, P.A., & Armstrong, R.W. (1997) Cyclobutenedione derivatives on solid support: Toward multiple core structure libraries. J. Amer. Chem. Soc., 119, 7607-7608. #10444

  797. Tenson, T., Xiong, L.Q., Kloss, P., & Mankin, A.S. (1997) Erythromycin resistance peptides selected from random peptide libraries. Journal of Biological Chemistry, 272, 17425-17430. #9470

  798. Terrett, N. (1997) Combinatorial chemistry: Xantines as a library scaffold. Drug Disc. Today, 2, 354-354. #9853

  799. Terrett, N. (1997) Combinatorial chemistry. Drug Disc. Today, 2, 394-394. #9398

  800. Terrett, N. (1997) Combinatorial chemistry. Drug Disc. Today, 2, 37-37. #8235

  801. Terrett, N. (1997) Combinatorial chemistry: A library of GPIIb/IIIa antagonists. Drug Disc. Today, 2, 207-209. #9851

  802. Terrett, N. (1997) Combinatorial chemistry. Drug Disc. Today, 2, 81-81. #8227

  803. Terrett, N. (1997) Combinatorial chemistry: Mathematical description of combinatorial chemistry. Drug Disc. Today, 2, 250-250. #9201

  804. Terrett, N. (1997) Combinatorial chemistry. Anticancer agents from OBOC libraries. Drug Disc. Today, 2, 124-124. #8388

  805. Terrett, N.K., Gardner, M., Gordon, D.W., Kobylecki, R.J., & Steele, J. (1997) Drug discovery by combinatorial chemistry: The development of a novel method for the rapid synthesis of single compounds. Chem. Eur. J., 3, 1917-1920. #10388

  806. Terry, T.D., Malik, P., & Perham, R.N. (1997) Accessibility of peptides displayed on filamentous bacteriophage virions: Susceptibility to proteinases. Biol. Chem. Hoppe-Seyler, 378, 523-530. #9500

  807. Thomas, J.B., Fall, M.J., Cooper, J.B., Burgess, J.P., & Carroll, F.I. (1997) Rapid in-plate generation of benzimidazole libraries and amide formation using EEDQ. Tetrahedron Lett., 38, 5099-5102. #9032

  808. Thomas, S.M., & Burke, J.F. (1997) Chiron: Combinatorial chemistry to vaccines [review]. Exp. Opin. Ther. Patents, 7, 299-306. #9266

  809. Thompson, P.E., & Hearn, M.T.W. (1997) Fmoc-protected tropane-based amino acids for peptide structure-function studies. Tetrahedron Lett., 38, 2907-2910. #8788

  810. Thornberry, N.A., Rano, T.A., Peterson, E.P., Rasper, D.M., Timkey, T., Garcia-Calvo, M., Houtzager, V.M., Nordstrom, P.A., Roy, S., Vaillancourt, J.P., Chapman, K.T., & Nicholson, D.W. (1997) A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional, relationships established for key mediators of apoptosis. Journal of Biological Chemistry, 272, 17907-17911. #9455

  811. Tietze, L.F., Steinmetz, A., & Balkenhohl, F. (1997) Solid-phase synthesis of polymer-bound beta-ketoesters and their application in the synthesis of structurally diverse pyrazolones. Bioorg. Med. Chem. Lett., 7, 1303-1306. #9191

  812. Tjernberg, L.O., Lilliehook, C., Callaway, D.J., Naslund, J., Hahne, S., Thyberg, J., Terenius, L., & Nordstedt, C. (1997) Controlling amyloid beta-peptide fibril formation with protease-stable ligands. Journal of Biological Chemistry, 272, 12601-12605. #10461

  813. Tomandl, D., Schober, A., & Schwienhorst, A. (1997) Optimizing doped libraries by using genetic algorithms. J. Comput. Aid. Molec. Design, 11, 29-38. #9268

  814. Tomkinson, N.C.O., Sefler, A.M., Plunket, K.D., Blanchard, S.G., Parks, D.J., & Willson, T.M. (1997) Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARgamma ligands. Bioorg. Med. Chem. Lett., 7, 2491-2496. #9988

  815. Tomlinson, J. J. High throughput quantitative analysis. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.413 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8329

  816. Torda, A.E. (1997) Perspectives in protein-fold recognition. Curr. Opin. Struct. Biol., 7, 200-205. #10459

  817. Torneiro, M., & Still, W.C. (1997) Simple synthetic receptors that bind peptides in water. Tetrahedron, 53, 8739-8750. #11602

  818. Tournamille, C., Levankim, C., Gane, P., Blanchard, D., Proudfoot, A.E., Cartron, J.P., & Colin, Y. (1997) Close association of the first and fourth extracellular domains of the Huffy antigen/receptor for chemokines by a disulfide bond is required for ligand binding. Journal of Biological Chemistry, 272, 16274-16280. #9514

  819. Trias, J., & Gordon, E.M. (1997) Innovative approaches to novel antibacterial drug discovery [review]. Curr. Opin. Biotechnol., 8, 757-762. #10392

  820. Tuerk, C. (1997) Using the SELEX combinatorial chemistry process to find high affinity nucleic acid ligands to target molecules. Methods Mol. Biol., 67, 219-230. #5765

  821. Turner, D.B., Tyrrell, S.M., & Willett, P. (1997) Rapid quantification of molecular diversity for selective database acquisition. Journal of Chemical Information and Computer Sciences, 37, 18-22. #8271

  822. Turner, D.J., Ritter, M.A., & George, A.J. (1997) Importance of the linker in expression of single-chain Fv antibody fragments: Optimization of peptide sequence using phage display technology. J. Immunol. Method, 205, 43-54. #10477

  823. Udaka, K. (1997) Libraries as a tool to explore the specificities of molecular interactions. Seikagaku, 69, 339-343. #10073

  824. Uebel, S., Kraas, W., Kienle, S., Wiesmuller, K.H., Jung, G., & Tampe, R. (1997) Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries. Proc. Natl. Acad. Sci. USA, 94, 8976-8981. #10072

  825. Ugi, I.K., Heilingbrunner, M.J., & Gruber, B. (1997) Heuristics, genetic algorithm and other vagaries of computer- based chemistry [german]. Chimia, 51, 39-44. #9167

  826. Underiner, T.L. & Peterson, J.R. (1997) Synthesis tools for solution-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 177-198). American Chemical Society, Washington,DC. #11699

  827. Uozumi, Y. (1997) Preparation of combinatorial library indexed by molecular tags. J. Syn. Org. Chem. Jpn., 55, 65-71. #8435

  828. Uozumi, Y., Danjo, H., & Hayashi, T. (1997) New amphiphilic palladium-phosphine complexes bound to solid supports: Preparation and use for catalytic allylic substitution in aqueous media. Tetrahedron Lett., 38, 3557-3560. #8850

  829. Vaccaro, P., Dente, L., Onofri, F., Zucconi, A., Martinelli, S., Valtorta, F., Greengard, P., Cesareni, G., & Benfenati, F. (1997) Anti-synapsin monoclonal antibodies: Epitope mapping and inhibitory effects on phosphorylation and Grb2 binding. Mol. Brain. Res., 52, 1-16. #10395

  830. Valenta, R., Flicker, S., Eibensteiner, P.B., Steinberger, P., Laffer, S., Dolecek, C., & Kraft, D. (1997) Recombinant allergen-specific antibody fragments: Tools for diagnosis, prevention and therapy of type i allergy [review]. Biol. Chem., 378, 745-749. #10396

  831. Van Ausdall, D. A. and Marshall, W. S. Automated high throughput mass spectral analysis of oligonucleotides. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.116 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8290

  832. van Breemen, R.B., Huang, C.R., Nikolic, D., Woodbury, C.P., Zhao, Y.Z., & Venton, D.L. (1997) Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal. Chem., 69, 2159-2164. #11415

  833. Van Ewijk, W., de Kruif, J., Germeraad, W.T., Berendes, P., Ropke, C., Platenburg, P.P., & Logtenberg, T. (1997) Subtractive isolation of phage-displayed single-chain antibodies to thymic stromal cells by using intact thymic fragments. Proc. Natl. Acad. Sci. USA, 94, 3903-3908. #10460

  834. Vanbreemen, R.B., Huang, C.R., Nikolic, D., Woodbury, C.P., Zhao, Y.Z., & Venton, D.L. (1997) Pulsed ultrafiltration mass spectrometry: A new method for screening combinatorial libraries. Anal. Chem., 69, 2159-2164. #9089

  835. Veber, D.F., Drake, F.H., & Gowen, M. (1997) The new partnership of genomics and chemistry for accelerated drug development. Curr. Opin. Chem. Biol., 1, 151-156. #10399

  836. Veerapandian, P. (1997) Structure-Based Drug Design. Marcel Dekker, New York. #11240

  837. Versalovic, J., & Lupski, J.R. (1997) Missense mutations in the 3' end of the Escherichia coli dnaG gene do not abolish primase activity but do confer the chromosome-segregation-defective (par) phenotype. Microbiology-UK, 143, 585-594. #8442

  838. Vincent, B., Jiracek, J., Noble, F., Loog, M., Roques, B., Dive, V., Vincent, J.P., & Checler, F. (1997) Contribution of endopeptidase 3.4.24.15 to central neurotensin inactivation. Eur. J. Pharmacol., 334, 49-53. #10400

  839. Vindigni, A., Dang, Q.D., & Di Cera, E. (1997) Site-specific dissection of substrate recognition by thrombin. Nat. Biotech., 15, 891-895. #9889

  840. Virgilio, A.A., Bray, A.A., Zhang, W., Trinh, L., Snyder, M., Morrissey, M.M., & Ellman, J.A. (1997) Synthesis and evaluation of a library of peptidomimetics based upon the beta-turn. Tetrahedron, 53, 6635-6644. #9300

  841. Vlattas, I., Dellureficio, J., Dunn, R., Sytwu, I.I., & Stanton, J. (1997) The use of thioesters in solid phase organic synthesis. Tetrahedron Lett., 38, 7321-7324. #9569

  842. Vo, N.H., Eyermann, C.J., & Hodge, C.N. (1997) Transformation of resin-bound pyridinium ylides: I. A stereoselective synthesis of 2,2,3-trisubstituted cyclopropanecarboxylates. Tetrahedron Lett., 38, 7951-7954. #9688

  843. Volkmer-Engert, R., Hoffmann, B., & Schneider-Mergener, J. (1997) Stable attachment of the HMB-linker to continuous cellulose membranes for parallel solid phase SPOT synthesis. Tetrahedron Lett., 38, 1029-1032. #8408

  844. von dem Bussche-Hunnefeld, C., Balkenhohl, F., Lansky, A., & Zechel, C. (1997) Combinatorial chemistry. Fresenius J. Anal. Chem., 359, 3-9. #10403

  845. Waldmann, H., & Reidel, A. (1997) The phenylacetyl group: The first amino protecting group that can be removed enzymatically from oligonucleotides in solution and on a solid support. Angew. Chem. Int. Ed., 36, 647-649. #12502

  846. Wallace, O.B. (1997) Solid phase synthesis of ketones from esters. Tetrahedron Lett., 38, 4939-4942. #9037

  847. Wallace, R.W. (1997) Drugs from the sea: Harvesting the results of aeons of chemical evolution. Mol. Med. Today, 3, 291-295. #9392

  848. Wallace, R.W. (1997) High-throughput screening: 1536-well plates at Pharmacopeia. Drug Disc. Today, 2, 355-355. #9854

  849. Wallace, R.W. & Goldman, M.E. (1997) Bioassay design and implementation. In J.P. Devlin (Ed.), High Throughput Screening: The Discovery of Bioactive Substances. (pp. 279-306). Marcel Dekker,Inc., New York. #9001

  850. Wang, F., & Hauske, J.R. (1997) Solid-phase synthesis of benzoxazoles via Mitsunobu reaction. Tetrahedron Lett., 38, 6529-6532. #9323

  851. Wang, F., & Hauske, J.R. (1997) Solid-phase synthesis of 3,4-dihydroquinazoline. Tetrahedron Lett., 38, 8651-8654. #9693

  852. Wang, G.T., Chen, Y., Wang, S., Sciotti, R., & Sowin, T. (1997) Solid phase synthesis of ureas of secondary amines via carbamoyl chloride. Tetrahedron Lett., 38, 1895-1898. #8609

  853. Wang, Y., & Wilson, S.R. (1997) Solid phase synthesis of 2,3-dihydro-4-pyridones: Reaction of Danishefsky's diene with polymer-bound imines. Tetrahedron Lett., 38, 4021-4024. #9049

  854. Warr, W.A. (1997) Combinatorial chemistry and molecular diversity. An overview. Journal of Chemical Information and Computer Sciences, 37, 134-140. #8274

  855. Warr, W.A. (1997) Commercial software systems for diversity analysis. Perspect. Drug Disc. Design, 7-8, 115-130. #10728

  856. Warren, M.S., & Benkovic, S.J. (1997) Combinatorial manipulation of three key active site residues in glycinamide ribonucleotide transformylase. Protein Eng., 10, 63-68. #8397

  857. Watkins, J.D., Beuerlein, G., Pecht, G., McFadden, P.R., Glaser, S.M., & Huse, W.D. (1997) Determination of the relative affinities of antibody fragments expressed in Escherichia coli by enzyme-linked immunosorbent assay. Anal. Biochem., 253, 37-45. #10409

  858. Watkins, L.M., Kuo, J.M., Chengoodspeed, M., & Raushel, F.M. (1997) A combinatorial library for the binuclear metal center of bacterial phosphotriesterase. Proteins, 29, 553-561. #10410

  859. Watson, S.P., Wilson, R.D., Judd, D.B., & Richards, S.A. (1997) Solid phase synthesis of 5-aminopyrazoles and derivatives. Tetrahedron Lett., 38, 9065-9068. #9864

  860. Watters, J.M., Telleman, P., & Junghans, R.P. (1997) An optimized method for cell-based phage display panning. Immunotechnology, 3, 21-29. #10464

  861. Webb, S.R., Lee, H., & Hall, J.C. (1997) Cloning and expression in Escherichia coli of an anti-cyclohexanedione single-chain variable antibody fragment and comparison to the parent monoclonal antibody. J. Agric. Food Chem., 45, 535-541. #8439

  862. Wei, L., Chang, J.T., & Altman, R.B. (1997) Using the radial distributions of physical features to compare amino acid environments and align amino acid sequences. Pac. Symp. Biocomput., 465-476. #9955

  863. Weinberger, H., Lichte, E., Griesinger, C., & Kutscher, B. (1997) Small peptide libraries: Combinatorial split-mix synthesis followed by combinatorial amino acid analysis of selected variants. Arch. Pharm., 330, 109-111. #9502

  864. Weller, H.N., Young, M.G., Michalczyk, S.J., Reitnauer, G.H., Cooley, R.S., Rahn, P.C., Loyd, D.J., Fiore, D., & Fischman, S.J. (1997) High throughput analysis and purification in support of automated parallel synthesis. Mol. Diversity, 3, 61-70. #10099

  865. Welschof, M., Terness, P., Kipriyanov, S.M., Stanescu, D., Breitling, F., Dorsam, H., Dubel, S., Little, M., & Opelz, G. (1997) The antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody. Proc. Natl. Acad. Sci. USA, 94, 1902-1907. #10439

  866. Wen, J.J., & Spatola, A.F. (1997) A systematic approach to the solid-phase synthesis of linear and cyclic pseudopeptide libraries containing psi[CH2NH]amide bond surrogates. J. Pept. Res., 49, 3-14. #8641

  867. Whitehouse, D.L., Nelson, K.H.Jr., Savinov, S.N., & Austin, D.J. (1997) A chemoselective rhodium(II) mediated solid phase 1,3-dipolar cycloaddition and its application to a thermally self-cleaving furan scaffold. Tetrahedron Lett., 38, 7139-7142. #9557

  868. Wieboldt, R., Zweigenbaum, J., & Henion, J. (1997) Immunoaffinity ultrafiltration with ion spray HPLC/MS for screening small-molecule libraries. Anal. Chem., 69, 1683-1691. #9130

  869. Wieland, T. (1997) Combinatorics of combinatorial chemistry. J. Math. Chem., 21, 141-157. #10416

  870. Wierenga, W. The challenge of drug discovery: Predictability of therapeutic utility. In: W. Hori. (Eds.) 1996; International Business Communications,Inc., Southborough p.1.2.1 #8880

  871. Wigger, M., Nawrocki, J.P., Watson, C.H., Eyler, J.R., & Benner, S.A. (1997) Assessing enzyme substrate specificity using combinatorial libraries and electrospray ionization fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom., 11, 1749-1752. #10417

  872. Wikel, J.H., & Higgs, R.E. (1997) Applications of molecular diversity analysis in high throughput screening. J. Biomol. Screen., 2, 65-67. #9296

  873. Wilcox, H.W., & Sorvillo, J.M. (1997) Early stage partnership models. J. Biolaw Business, 1, 36-39. #9605

  874. Willems, H. (1997) New combinatorial chemistry. Drug Disc. Today, 2, 214-217. #9199

  875. Willett, P. (1997) Using computational tools to analyze molecular diversity. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 17-48). American Chemical Society, Washington,DC. #11695

  876. Willett, P. (1997) Computational tools for the analysis of molecular diversity [review]. Perspect. Drug Disc. Design, 7-8, 1-11. #10723

  877. Williams, S.C., Badley, R.A., Davis, P.J., Puijk, W.C., & Meloen, R.H. (1997) Detailed epitope mapping of bovine beta lactoglobulin. Biochem. Soc. Trans., 25, S:161. #9204

  878. Williamson, R.A., Lazzarotto, T., Sanna, P.P., Bastidas, R.B., Casa, B.D., Campisi, G., Burioni, R., Landini, M.P., & Burton, D.R. (1997) Use of recombinant human antibody fragments for detection of cytomegalovirus antigenemia. J. Clin. Microbiol., 35, 2047-2050. #9393

  879. Williard, X. & Tartar, A. (1997) Deconvolution tools in solution-phase synthesis. In A.W. Czarnik & S.H. DeWitt (Eds.), A Practical Guide to Combinatorial Chemistry. (pp. 249-277). American Chemical Society, Washington,DC. #11701

  880. Wilson, S.R. (1997) Introduction to combinatorial libraries: Concepts and terms. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 1-24). John Wiley & Sons,Inc., New York. #8350

  881. Wilson, S.R., & Czarnik, A.W. (1997) Combinatorial Chemistry. Synthesis and Applications. John Wiley & Sons,Inc., New York. ISBN 047112687X #8349

  882. Wintner, E.A. & Rebek, J.Jr. (1997) Combinatorial libraries in solution: Polyfunctionalized core molecules. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 95-118). John Wiley & Sons,Inc., New York. #8354

  883. Wipf, P., & Henninger, T.C. (1997) Solid-phase synthesis of peptide mimetics with (E)-alkene amide bond replacements derived from alkenylaziridines. J. Org. Chem., 62, 1586-1587. #9168

  884. Wipf, P., Cunningham, A., Rice, R.L., & Lazo, J.S. (1997) Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors. Bioorg. Med. Chem., 5, 165-177. #9342

  885. Wodicka, L., Dong, H., Mittmann, M., Ho, M.H., & Lockhart, D.J. (1997) Genome-wide expression monitoring in saccharomyces cerevisiae. Nat. Biotech., 15, 1359-1367. #10418

  886. Wu, J.Y., Takayama, S., Wong, C.H., & Siuzdak, G. (1997) Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors. Chem. Biol., 4, 653-657. #9887

  887. Wu, M.H., & Jacobsen, E.N. (1997) An efficient formal synthesis of balanol via the asymmetric epoxide ring opening reaction. Tetrahedron Lett., 38, 1693-1696. #8858

  888. Xiao, X., Zhao, C., Potash, H., & Nova, M.P. (1997) Combinatorial chemistry with laser optical encoding. Angew. Chem. Int. Ed., 36, 780-782. #8726

  889. Xiao, X.Y., Parandoosh, Z., & Nova, M.P. (1997) Design and synthesis of a taxoid library using radiofrequency encoded combinatorial chemistry. J. Org. Chem., 62, 6029-6033. #10421

  890. Xiao, X.Y. & Nova, M.P. (1997) Radiofrequency encoding and additional techniques for the structure elucidation of synthetic combinatorial libraries. In S.R. Wilson & A.W. Czarnik (Eds.), Combinatorial Chemistry. Synthesis and Application. (pp. 135-152). John Wiley & Sons,Inc., New York. #8356

  891. Xiao, X.Y., Ngu, K., Chao, C., & Patel, D.V. (1997) Selective solid phase synthesis of ureas and hydantoins from common phenyl carbamate intermediates. J. Org. Chem., 62, 6968-6973. #10420

  892. Xu, C.W., Mendelsohn, A.R., & Brent, R. (1997) Cells that register logical relationships among proteins. Proc. Natl. Acad. Sci. USA, 94, 12473-12478. #10422

  893. Xu, J., & Ma, Y. (1997) Simultaneous multiple organic synthesis. Huaxue Tongbao, 1-8. #8652

  894. Xu, W., Mohan, R., & Morrissey, M.M. (1997) Polymer supported bases in combinatorial chemistry: Synthesis of aryl ethers from phenols and alkyl halides and aryl halides. Tetrahedron Lett., 38, 7337-7340. #9571

  895. Yaffe, M.B., Rittinger, K., Volinia, S., Caron, P.R., Aitken, A., Leffers, H., Gamblin, S.J., Smerdon, S.J., & Cantley, L.C. (1997) The structural basis for 14-3-3: Phosphopeptide binding specificity. Cell, 91, 961-971. #10424

  896. Yamabhai, M., & Kay, B.K. (1997) Examining the specificity of Scr homology 3 domain-ligand interactions with alkaline phosphatase fusion proteins. Anal. Biochem., 247, 143-151. #9981

  897. Yan, B., & Sun, Q. (1997) Crucial factors regulating site interactions in resin supports determined by single bead IR. J. Org. Chem., 63, 55-58. #10016

  898. Yan, B., & Li, W. (1997) Rapid fluorescence determination of the absolute amount of aldehyde and ketone groups on resin supports. J. Org. Chem., 62, 9354-9357. #9856

  899. Yan, B. (1997) Monitoring the progression of organic reactions on solid supports. Recent Res. Dev. Org. Chem., 1, 55-65. #10018

  900. Yanagisawa, J., Takahashi, M., Kanki, H., Yanoyanagisawa, H., Tazunoki, T., Sawa, E., Nishitoba, T., Kamishohara, M., Kobayashi, E., Kataoka, S., & Sato, T. (1997) The molecular interaction of Fas and FAP-1: A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis. Journal of Biological Chemistry, 272, 8539-8545. #9270

  901. Yang, L., & Chiu, K. (1997) Solid phase synthesis of Fmoc N-methyl amino acids: Application of the Fukuyama amine synthesis. Tetrahedron Lett., 38, 7307-7310. #9568

  902. Yang, Y.Y., Fischer, P., Leu, S.J.C., Olee, T., Carson, D.A., & Chen, P.P. (1997) IgG rheumatoid factors isolated by the surface-displaying phage library technique. Immunogenetics, 45, 301-310. #9290

  903. Ye, X.S., Xu, G., Fincher, R.R., & Osmani, S.A. (1997) Characterization of NIMA protein kinase in Aspergillus nidulans. Methods Enzymol., 283, 520-532. #10457

  904. Yoo, S.E., Seo, J.S., Yi, K.Y., & Gong, Y.D. (1997) Solid phase synthesis of biphenyltetrazole derivatives. Tetrahedron Lett., 38, 1203-1206. #8391

  905. You, A.J., Jackman, R.J., Whitesides, G.M., & Schreiber, S.L. (1997) A miniaturized arrayed assay format for detecting small molecule-protein interactions in cells. Chem. Biol., 4, 969-975. #10429

  906. Young, A.C.M., Valadon, P., Casadevall, A., Scharff, M.D., & Sacchettini, J.C. (1997) The three-dimensional structures of a polysaccharide binding antibody to cryptococcus neoformans and its complex with a peptide from a phage display library: Implications for the identification of peptide mimotopes. J. Mol. Biol., 274, 622-634. #10430

  907. Young, S.S., Sheffield, C.F., & Farmen, F. (1997) Optimum utilization of a compound collection or chemical library for drug discovery. Journal of Chemical Information and Computer Sciences, 37, 892-899. #9847

  908. Youngman, M.A., & Dax, S.L. (1997) Mannich reactions of a resin-bound terminal alkyne. Tetrahedron Lett., 38, 6347-6350. #9320

  909. Yu, Z., & Chu, Y.H. (1997) Combinatorial epitope search: Pitfalls of library design. Bioorg. Med. Chem. Lett., 7, 95-98. #10020

  910. Zaragoza, F. (1997) Solid phase synthesis of cyanoacetamidines: Fast access to potential bioisosteres of acceptor-substituted guanidines. Tetrahedron Lett., 38, 7291-7294. #9566

  911. Zasadzinski, J.A. (1997) Novel approaches to lipid based drug delivery [Review]. Curr. Opin. Solid State Material. Sci., 2, 345-349. #9397

  912. Zeng, L., Burton, L., Yung, K., Shushan, B., & Kassel, D.B. (1997) An automated analytical/preparative LC/MS system for the characterization and purification of compound libraries. J. Chromatogr. A, #10064

  913. Zenie, F. H. It's only a matter of time. In: Anonymous. (Eds.) Zymark Corporation, Hopkington, MA p.15 Proceedings of the International Symposium on Laboratory Automation and Robotics 1996. #8280

  914. Zhang, H.C., Brumfield, K.K., & Maryanoff, B.E. (1997) Synthesis of trisubstituted indoles on the solid phase via palladium-mediated heteroannulation of internal alkynes. Tetrahedron Lett., 38, 2439-2442. #8778

  915. Zhang, H.C., & Maryanoff, B.E. (1997) Construction of indole and benzofuran systems on the solid phase via palladium-mediated cyclizations. J. Org. Chem., 62, 1804-1809. #8466

  916. Zhao, H., & Arnold, F.H. (1997) Combinatorial protein design: Strategies for screening protein libraries. Curr. Opin. Struct. Biol., 7, 480-485. #9356

  917. Zhao, P.L., Zambias, R., Bolognese, J.A., Boulton, D., & Chapman, K. (1997) Sample size determination in combinatorial chemistry (Vol 92, Pg 10212, 1995). Proc. Natl. Acad. Sci. USA, 94, 7120-7120. #9507

  918. Zhao, S.M., & Lee, E.Y. (1997) A protein phosphatase-1-binding motif identified by the panning of a random peptide display library. Journal of Biological Chemistry, 272, 28368-28372. #10433

  919. Zhao, Y.Z., van Breemen, R.B., Nikolic, D., Huang, C.R., Woodbury, C.P., Schilling, A., & Venton, D.L. (1997) Screening solution-phase combinatorial libraries using pulsed ultrafiltration/electrospray mass spectrometry. J. Med. Chem., 40, 4006-4012. #10434

  920. Zhao, Z.G. & Lam, K.S. (1997) Synthetic peptide libraries. In W.H. Moos, M.R. Pavia, B.K. Kay & A.D. Ellington (Eds.), Annual Reports in Combinatorial Chemistry and Molecular Diversity. (pp. 192-209). ESCOM, Leiden. #8624

  921. Zheng, Q., & Kyle, D.J. (1997) Computational screening of combinatorial libraries via multicopy sampling [review]. Drug Disc. Today, 2, 229-234. #9200

  922. Zhong, G., Berry, J.D., & Choukri, S. (1997) Mapping epitopes of neutralizing monoclonal antibodies using phage random peptide libraries. J. Ind. Microbiol. Biotechnol., 19, 71-76. #10074

  923. Zhou, B.N., Baj, N.J., Glass, T.E., Malone, S., Werkhoven, M.C., Vantroon, F., Wisse, J.H., & Kingston, D.G. (1997) Bioactive labdane diterpenoids from renealmia alpinia collected in the suriname rainforest. J. Nat. Prod. -Lloydia, 60, 1287-1293. #10436

  924. Ziegler, A., Macintosh, S.M., Torrance, L., Simon, W., & Slabas, A.R. (1997) Recombinant antibody fragments that detect enoyl acyl carrier protein reductase in Brassica napus. Lipids, 32, 805-809. #10454

  925. Zurer, P. (1997) Porous silicon biosensor. Exquisitely sensitive portable sensor promises to have many uses. C&EN, 7-7. #11750


Monday, May 15, 2000