Solid phase synthesis of benzamidine and butylamine-derived hydantoin libraries

Sang Woong Kim, Jong Sung Koh, Seonggu Ro
Biotech Research Institute, LG Chemical Ltd./Research Park, Science Town, Taejon 305-380, Korea

Eun Ju Lee
Korea Advanced Institute of Science and Technology, Science Town, Taejon 306-701, Korea

Abstract
We have constructed a number of benzamidine- and butylamine-based hydantoin compounds by means of an efficient route using solid phase synthesis in which neat diisopropylamine was employed for a novel cyclization/traceless cleavage step. All library compounds were obtained in excellent yield and high purity.

Keywords
benzamidine, butylamine-based hydantoin libraries, solid phase synthesis, traceless cleavage