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O08 Practical Green Aqueous Solid-Phase Peptide Synthesis (ASPPS) Using Nanoassemblies of Fmoc-Amino Acids: A DMF-Free Approach
Keiko Hojo, Ayumi Nonaka, Yuki Manabe, Cedric Rentier, Amit Mehrotra, Kazuhito Hioki, Munetaka Kunishima
O12 Neurotensin(8-13) Analogs Targeting NTS1 and NTS2 Receptors: A Comparative In vitro and Molecular Modeling Study
Nikolay T. Tzvetkov, Kiril Kirilov, Maya G. Georgieva, Aneliya A. Balacheva, Tamara I. Pajpanova, Toni Kühl, Harald Hübner, Peter Gmeiner, Diana Imhof
O32 Peptide Nucleic Acid Probes for Affinity-Based Targeted Cancer Therapy
Amelie Eriksson Karlström
O37 Sequence-driven modulation of the multistage self-assembly process in lamellin-type β-peptides
Imola Cs. Szigyártó, K. Ferentzi, András Wacha, Kamal el Battioui, Olivér Pavela, Tünde Juhász, Judith Mihály, István Mándity, Viktor Farkas, Tamás Beke-Somfai
O46 Total synthesis of the proposed structure of threoglucin A
Natalia Cano-Sampaio, Juan Del Valle
O49 Cyclopeptide-Based Fluorescent Conjugates for Monitoring Prefibrillar Aβ42 Nanostructures
Steven Panek, Anne Cécile Van Baelen, Norbert Sewald, Nicolo Tonali
O51 Synthesising Libraries of a,d-Foldamers using Solid Phase Peptide Synthesis
Si Zhe Wang, Andre Cobb
O53 Retro-Inverted Host Defense Peptides as Inhalable Antitubercular Therapies
Diptomit Biswas, Hugh D. Glossop, Gebremichal Gebretsadik, Sabiha Sultana, Nathan A. Schacht, Neela H. Yennawar, Muzafar Ahmad Rather, Anthony D. Baughn, Scott H. Medina
O55 Searching for Nanostructured or pOre fOrming Peptides for therapY COST Action
Daniela Kalafatovic
O60 Computational/Experimental Symbiosis to Design Functional Supramolecular Peptide Assemblies
Ivan R Sasselli
O63 Discovery of novel peptide-GPCR signalling systems across evolutionary domains
Luuk R. H. Dijkhof, Teemu K.E. Rönkkö, Marin Matic, Alexander S. Hauser
P001 Diastereoselective Ugi Reactions via Biocatalytic Desymmetrization: A Modular Route to Collagen Mimetic peptides
Felix M.J. Boerman, Jannes Wagemakers, Alessia Bubula, Daniele Castagnolo, Romano V.A. Orru, Jordy M. Saya
P002 Diagnostic 7-Mer Model Peptide for Rapid Evaluation of Cysteine Racemization in Solid-Phase Peptide Synthesis
Saundra Mason, Wesley Grenier, Dario Slavazza, Hanson Chang
P005 Tag-Assisted Peptide Synthesis (TAPS) Enabling Efficient and Sustainable Peptide Synthesis and Purification
Raimund Maier, Karin Rustler, Haixiang Zhang, Thomas Bruckdorfer, Kai Holland-Nell, Jacqueline Dalski, Stephan Pritz
P008 Total Chemical Synthesis of RNF4 by Sequential Native Chemical Ligation: C-To-N Versus N-To-C Strategies
Saed Bisher, Rajesh Pallava, Ashraf Brik
P010 C-Glycosyl a-Amino Acids as Structural Encoders of Peptide Conformation
Ivanka Jeric, Barbara Bogovic, Ivana Nikšic-Franjic
P013 Scalable PEC Purification Enables API-Grade Semaglutide with Minimal HPLC Intervention
Stephan Lüdtke, Lucrezia Sforza, Manoj Muthyala, Robert Zitterbart, Dominik Sarma, Paolo Rovero, Anna Maria Papini
P014 Synthesis, Radiolabelling and Preliminary Characterization of an EGFR-Targeting DOTA-Conjugated Peptide for Cancer Imaging
Aline De Souza, Leonardo Carvalheira, Marycel Barboza, Fernanda Mendonca, Leonardo Fuscaldi, Luciana Malavolta
P019 Pyridium-p Interaction Preserves the N,S-benzylidene Thioacetals (NTDs) in Acidolysis Enabling Efficient Protein Chemical Synthesis
Zhenquan Sun, Yaoyue Zhang, Xueqian Zhao, Yisa Xiao, Zhixiang Zhong, Hongxiang Wu. Xuechen Li
P020 Development of a Generalized Platform for Hydrophobic Peptide Synthesis by Utilizing WuXi TIDES-Solubilizing Tag
Qingqing Zhou, Xiaosheng Luo, Yazhou Li, Xiao Zhang, Yvonne Angell, Li Wang, Haiying He
P023 Towards peptide libraries: HPLC-based flow peptide synthesis and combinatorial chemistry
Viktor Farkas, Kristóf Ferentzi, András Perczel
P025 High-Loading Seplife Fmoc-RinkAmide-PS-PEG Resin: A Robust Solid Support for the Synthesis of Complex Peptides and Tirzepatide
A. Kumar, P.K. Kabwe, M. Alhassan, W. Hou, C. Wang, C. Zhang, Y. Li, XK. Kou, A. Basso, A. Sharma, BG. De La Torre, F. Albericio
P027 Accelerating peptide discovery via high throughput plate-based synthesis
An Nguyen, Siddique Amin, Caroline Morris, Christina Dumitriu Jackson, Hannah Bolt, Jefferson Revell
P028 A Novel Metal Catalyzed Peptide Ligation Method
Nathalie Ollivier, Remi Desmet, Oleg Melnyk
P029 Catalytic peptide-based coacervates for enhanced function through structural organization and substrate specificity
David Reis, Sara Pereira, Ana Ramos, Pedro Pereira, Leonor Morgado, Joana Calvário, Ana Pina
P032 Peptide functionalization of hybrid polyoxometalates
Teresa Bell, Nadiia Gumerova, Annette Rompel
P033 Accelerated Linker-Free Solid-Supported Native Chemical Ligation
Océane Bonningue, Vincent Diemer, Oleg Melnyk
P034 From Monomers to Dendrimers: Novel Synthetic Strategies for Highly Branched Peptide Nanostructures for Next-Generation Drug Delivery
Tom Götze-Ebert, Frida Fritzsche, Christina Lamers
P038 Induction heating solid-phase strategy to improve the total chemical synthesis of ester insulin
Silvia Bracci, Michael Quagliata, Paolo Rovero, Stephen B.H. Kent, Anna Maria Papini
P039 Engineering nucleophilic catalysis coupled to tandem electrostatic assistance enables native chemical ligation at nanomolar concentrations
Julie Di Adamo, Vincent Diemer, Oleg Melnyk
P042 Direction-Switching One-Pot Peptide Ligation with Orthogonal Cysteinyl Protection
Koki Nakatsu, Fumika Yoshitomi, Hiroki Onoda, Reia Shikimachi, Kyohei Arita, Akimitsu Okamoto, Hiroshi Murakami, Gosuke Hayashi
P044 Methionine Oxidation Effect on GLP-2 Synthesis and Amyloid Kinetics
Szebasztián Szaniszló, Dániel Horváth, Kata Geszti, Anna J. Kiss-Szemán, Dóra K. Menyhárd, András Perczel
P045 Thiol-yne Mediated Peptide Macrocyclisation and Derivatisation Strategies
Conor Williams, Dearbhla Tully, Konstantin Raabe, Dominik Windisch, James O'Brien, Cristina Trujillo, Joanna F. McGouran, Markus Muttenthaler, Eoin M. Scanlan
P047 Affinity-driven transfer of a mass tag for the direct profiling of matrix metalloproteases in complex biological matrices
Lomane Berthy, Ugo Pasco, Mylene Sejalon-Cipolla, Monika Kaminska, Carole Malgorn, Fabrice Beau, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia,Olivier Lequin, Sarah Bregant, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel
P048 Clustered antigen architectures enhance monoclonal antibody adhesion: insights from biomimetic surfaces
Océane Ricloux, Laure Bar, Quentin Laurent, Liliane Guerente, Didier Boturyn
P052 Engineering a snake toxin as a positron emission tomography agent for diagnosing metastatic renal carcinoma
Goran Stanajic Petrovic, Charles Truillet
P055 New therapeutic option in autoimmune diseases to prevent the release of soluble CD95L
Marie Launay, Sarah Huot-Marchand, Farah Kotaich, Patrick Blanco, Patrick Legembre, Laurent Devel
P058 Modulating Integrin and Growth Factor Signaling with Synthetic Peptides: a New Paradigm in Regenerative Medicine
Carlos Mas-Moruno
P062 Olfactory Inspired Peptides as Tuneable Platforms for Selective Detection of Explosives
Adriana Rathner, Prabhat Prakash, Julian Widhalm, Malina Mairhofer, Vera Podrabska, William III Goddard
P067 Small Molecules, Big Impact: Quantifying the Influence of Amino Acids on Protein Interactions
Pamina M. Winkler, Christian F.W. Becker
P070 Stapled Peptide Inhibitors Targeting pre-miR-155 to Suppress miRNA Maturation
Heejoo Roh, Jinseo Heo, Yeongju Lee
P072 Screening of Algae Processing Technology for Easily Digestible Bioactive Hydrolysates
Ladislav Bim, Miloš Jelinek, Lubomir šánek, Veronika Matušu, Pavla švestková, Jiri Pecha
P073 Development of PNA-Based Antisense Oligonucleotides Targeting XIAP mRNA for Sensitizing TRAIL-Resistant Cancer Cells
Hyein Jung, Yeongju Lee
P074 Role Of Metal Nanoparticles As Artificial Chaperones In Modulating The Aggregation Propensity Of ?-Amyloid (Aβ40) Polypeptide
Harshit Kalra, Suman Jha
P076 Characterizing the cell-permeability, stability and toxicity of high affinity foldamer targeting the histone chaperone ASF1
Emma Maillard, B. Li, M. Perrin, A. Vitard, G. Moal, J. Mbianda, C. André, M. Teixerira-Nunes, M. Vandamme, G. Pinna, C. Douat, E. Thinon, R. Guerois, P. Legrand, F. Ochsenbein
P081 Rapid Assessment of Size, Shape, and Chemical Complementarity of Ligands for Computational Protein Design
Rokas Petrenas, Katarzyna Ozga, Joel J. Chubb, Andrey V. Romanyuk, Jennifer J. McManus, Graham J. Leggett, Nigel S. Scrutton, Thomas A. A. Oliver, Derek N. Woolfson
P086 A (poly)Pro tip for preserving native disulfide connectivity during thiol-maleimide bioconjugation of disulfide-rich peptides
Lylia Azzoug, Ana Novak, Hervé Meudal, Jean-Baptiste Madinier, Stéphane Charpentier, Karine Loth, Séverine Morisset-Lopez, Carlo Pifferi, Vincent Aucagne
P091 Random versus site-specific conjugation: impact on ADME properties of biologics with different format
Georgina Ilieska, Robert Thai, Carole Malgorn, Steven Dubois, Melissa De Souza, Camille Le Drezen, Justyne Vetel, Mathilde Keck, Antoine Sallustrau,Stephane Hua, Herve Nozach, Nicolas Joubert,Caroline Denevault-Sabourin,Laurent Devel
P095 Redox-Responsive Peptide Dimers to Stabilize and Release Therapeutic dsRNA
Marvin A. Albers, Niall M. McLoughlin, Zainab M. Rashid, David Dulin, Tom N. Grossmann
P097 Post-translational modifications regulate a synuclein aggregate structure and propagation properties
Yan-Mei Li
P100 Engineering Softness: How Molecular Tweeks in Coiled Coil Shape Hydrogel Behavior
Annelie Puhlmann, Cihan Baydaroglu, Merten Strehlau, Santiago Andres Ardila Fernandez, Boris Schade, Michael Gradzielski, Beate Koksch
P108 From inhibitor to affinity probe: Pepstatin A derivates enable AfBPP of plant aspartic proteases
Pierre Bena, Paula Dewes, Alexander Ciattoni, Leonardo González Ceballos, Bernhard Westermann, Pitter Huesgen, Mariana Schuster
P111 Conformational reprogramming of c-Myc via intracellular cyclisation
Rachel A. Johnson, Jody M. Mason
P116 Investigating the Synergistic Effect of Acetylation and Phosphorylation on Alpha-Synuclein Function Using Bioorthogonal Chemistry
Bernard Abakah, Marie Shimogawa, Grace Shin Hye Park, Elizabeth Rhoades, E. James Petersson
P120 Novel melanogenesis-modulating peptides for dermocosmetic applications
Carmen Gallo, Fosca Errante, Cristina Luceri, Paolo Rovero
P121 Peptide Therapeutics Targeting Drp1-Mid51 Protein-Protein Interactions to Preserve Mitochondrial Dynamics in Cardiovascular Disease
Rajkumar Khubiram, Liron Davis, Nir Qvit
P122 Electronic Reprogramming of Amylin Self-Assembly via Single-Residue Aromatic Tuning
Artem Pavlov, Hossein Batebi, Nicklas österlund, Kevin Pagel, Mario Schubert, Roland Netz, Beate Koksch
P123 Macrocyclic Molecular Glues for the 14-3-3/ChREBP Interaction; Affinity and Cooperativity in an Inverse Relationship
Merel van den Bosch, Marloes Pennings, Ansgar Oberheide, Carlo Verhoef, Christian Ottmann, Albert Markvoort, Galen Miley, Luc Brunsveld
P127 Lys acetylation and Ser phosphorylation crosstalk in the nucleosome binding domain of HMGN1
Medine Soydan, Anne C. Conibear
P128 Deciphering the Role of Posttranslational Modifications on the DNA-Binding Activity of Max Transcription Factor Using Chemical Protein Synthesis
Nithun Raj V, Yumi Minyi Yao, Omer Harel, Shada Khoury, Shaimaa Habiballah, Xiaoxi Lin, Ariel Afek, Muhammad Jbara
P130 Miniaturized HOXB13 Mimetics Are Sequence-Specific, Methyl-Sensitive DNA Binders
Claire Wong, Shiao.Y. Chow
P131 Enhancing Affinity of Peptide and Peptoid Ligands Using Boronic Acid-Catechol Reversible Dimerization
Elizabeth Bredice, Madeline Swanson,Thomas Kodadek, Skander Abboud
P132 Azapeptide Assembly Using Resonant Acoustic Mixing
William D. Lubell, Michael Quagliata, Justin Desjardins-Michaud, Nassim Maarouf-Mesli, Ida Boccino, Zahra Bigdeli, Felix Polyak
P133 Smart Amino Acid-based Nanovectors for RNA Anti-viral Therapeutics: Design, Synthesis and Physicochemical / Biological Characterization
Luisa do Vale, Sandra Silva, Pedro Cardoso, Isabel Oliveira, Eduardo Marques
P135 Synthesis of novel chiral peptoid-based metal chelators
Ludovica Dei, Bethany L Hardman, Gary J Sharples, Gaetano Angelici, Gennaro Pescitelli
P136 Downsizing The Histone H3-H4 Quaternary Structure Into Foldamer Mimetics Yields High-Affinity And Cell-Permeable Ligands Of Asf1
G. Guichard, B. Li, M. Perrin, E. Maillard, A. Vitard, G. Moal, J. Mbianda, C. André, M. T. Nunes, M. Vandamme, G. Pinna, C. Douat, E. Thinon, R. Guerois, P. Legrand, F. Ochsenbein
P138 Target-Directed Stapled Peptides through Dynamic Combinatorial Chemistry
Ashmi Rodrigues, Jose Garcia Coll, Delphine Ravault, Benjamin Zagiel, Ludovic Carlier, Lou Rocard, Roba Moumné
P139 Toward True avβ8 Selectivity: Cyclopeptide Ligands that Discriminate Homologous Integrins
Chiara Savian, Michela Spirelli, Andrea Sartori, Pietro Delcanale, Cristiano Viappiani, Monica Civera, Francesca Vasile, Laura Belvisi, Franca Zanardi, Lucia Battistini
P141 Design and synthesis of novel antibacterial oligourea foldamers
Kinga Chaniewicz, Paulina Bachurska-Szpala, Renata Kurek, Katarzyna Kozak, Karolina Pulka-Ziach
P144 Amino-acid based amphiphiles as chemical permeation enhancers, for transdermal drug delivery: Synthesis and In vitro permeation activity
Barbara Sampaio, Maria L.C. do Vale
P146 Development of a G protein mimetic toolbox to conformationally lock G protein coupled receptors (GPCRs) in the active state
Thijs Vynckier, Morgane Mannes, Morgane Rivoal, Charlotte Martin, Christel Menet, Toon Laeremans, Jean-Louis Baneres, Steven Ballet
P147 ?/a-Foldamers: Helical Constructs for asymmetric Catalysis
Junyan Xu, Dr. Saidul Islam, Prof. Andre Cobb
P148 Engineering Robust and Photoswitchable β-turns Through Hydrazide Incorporation
Samprete Bhattacharyya, Kalpita Baruah, Bani Kanta Sarma
P149 Comparison of conformational propensities of peptide backbones containing 1,5- or 1,4- disubstituted [1,2,3] triazoles
Francesco Brenzini Biagioni, Karine Porte, Pierre-Yves Renard, Anna Maria Papini
P152 Scalable Cyclic Peptide Synthesis Featuring Copper-Catalyzed Aldehyde-Alkyne-Amine Chemistry
Nassim Maarouf-Mesli, Felix Polyak, William D. Lubell
P154 Structure-Guided Synthesis of Triazole-Stabilized Peptidomimetics as Inhibitors of New Delhi Metallo-β-Lactamase-1
Msanif Msanif, M. Jewginski, F. Nuti, P. Rovero, A. M. Papini, R. Latajka
P156 Full Circle Chemistry: Expanding Macrocyclic Peptidomimetics
Jacob Simms, Oscar Shepperson, Michael Malone, Andrew Reid, Maxime Rouah, David Battersby, Andrew Jamieson
P157 Structure-Based Design Leads to uPA Loop Mimetic that Accumulates in uPAR-expressing Tumors in Mice
E. Vangeloven, S. Pollenus, M. Hosseini, T. Dal Maso, W. Versées, S. Ballet
P161 Controlling Nanonet Morphology via Residue-Specific Modulation of β-hairpin Peptide for Enhanced Bacterial Trapping
Wei Meng Chen, Dhanya Mahalakshmi Murali, Nhan Dai Thien Tram, Peiyan Yu, Daniel Tianyu Wang, Pui Lai Rachel Ee
P162 Trade-offs in Antimicrobial Peptide Activity: Faster Is not Always Better
Alessio Fragasso, Tatjana Schlechtweg, Wei-Hsiang Lin, Annelise Barron, Christine Jacobs-Wagner
P163 NMR-based Structure-Activity Relationship Studies of Antimicrobial Peptides
Michael Quagliata, Sonja Bazhenova, Joshua Grabeck, Philipp Holz, Anna Maria Papini, Paolo Rovero, Ines Neundorf, Daniel Friedrich
P165 Cyclo-(His-Phe) Complexes with Copper and Zinc Nanoparticles Have Targeted Anticancer Potential Against Osteosarcoma Cells
Anna Mitraki, Chrysanthi Pinelopi Apostolidou, Georgios Charalambidis, Aikaterini Gialouri, Maria Chatzinikolaidou
P166 SAR Study of Antimicrobial Peptide with Cross-Kingdom Activity
Aparna Palakkurussi Rathessan, Fereshteh Ghazisaeedi, Krithika Unmesh, Pascal-Kolja Bingül, Johannes Kupke, Suvrat Chowdhary, Dennis Hanke, Maria Andrea Mroginski, Marcus Fulde, Beate Koksch
P169 Mining bacteriophage endolysin structures for novel membrane-active antibacterial peptides
Monika Wojciechowska, Mateusz Wdowiak, Emil Stefanczyk, Joanna Trylska
P172 Development of an inhibitor of plasminogen activator inhibitor (PAI-1) for the treatment of inflammatory and fibrotic disorders
Eszter Erdei, Nikolett Varró Kormosné, Boldizsár Jójárt, Petra Pallagi, József Maléth, István Mándity
P180 Identification of novel peptide binders targeting TPP riboswitch in E. coli
Jinseo Park, Yujin Jung, Dasom Song, Jung Kim, Hong Gi Kim
P183 Antibacterial Activity of Novel Oncocin-Peptoid Hybrids
Jacopo Bucchioni, Bee Ha Gan, Markus Orsi, Robert Rauscher, Norbert Polacek, Jean-Louis Reymond
P184 Peptide-Daunomycin Conjugates Targeting Glioblastoma Cells
Levente Endre Dókus, Lili Szokolai, Viktor Farkas, Szilvia Bosze, Gábor Mezo
P185 Synthesis And Characterization Of Ferrocene-Peptide Conjugates With Antimicrobial Activity
Martina Rotondo, Annalisa Bisello, Saverio Santi, Fernando Formaggio, Simona Oancea, Teodora Calin, Anna Mkrtchyan, Liana Hayriyan, Tatevik Sargsyan, Cristina Peggion, Barbara Biondi
P188 Deciphering the Role of Citrulline and Cyclization in the Rational Design of Antimicrobial Peptides Derived from Equinin B
Andreja Jakas, Mariele Staropoli, Lea Pašalic, Anna Marin, Jasmina Tuzlak, Nermina Malanovic
P191 Stability and Antimicrobial Activity of Synthetic Peptides Derived from Lactoferricin B20-30
Tamara I. Pajpanova, Ivan P. Bogdanov, Momtchil Lambev, Georgi I. Ivanov, Silvia Mihaylova, Victor Sándor, Kveta Kalikova, Nikolay T. Tzvetkov, Ferenc Kilar
P192 Discovery Of An Antiviral Protease Inhibitor From Cytosorb Desorbate (Identification of SPINK1 from CytoSorb Desorbateas a Novel Antiviral TMPRSS2 Inhibitor)
Armando A. Rodriguez Alfonso, Jan Lawrenz, Nico Preising, Ludger Standker, Sebastian Wiese, Eberhard Barth, Frank Kirchhoff, Jan Münch
P193 ARHLFW: More than a cosmetic peptide
Y. Sarigiannis, A. Miliotou, T. Panayi, Ch. Petrou, P. Rodosthenous, P. Kaloumenos, C.M. Samiotou, M.V. Fronimou, C.M. Mikelis
P198 Discovery and membrane-selective bactericidal activity of Spat1, a novel cyclotide from Spigelia anthelmia L. (Loganiaceae)
Toluwanimi E. Akinleye, Latifat Sidiq, Alfred F. Attah, Roland Hellinger, Lisa Pabi, Nermina Malanovic, Omonike O. Ogbole, Christian W. Gruber
P202 An N-capping asparagine-lysine-proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold
Joao P.F. Pimentel, Lai Y. Chan, E.S. Candido, D.F. Buccini, Samilla B. Rezende, Marcelo D. T. Torres, Karen G. N. Oshiro, Itala C. Silva, Sonia Goncalves, T.K. Lu, Nuno C. Santos, Cesar de la Fuente-Nunez, David J. Craik, O.L. Franco, M.H. Cardoso
P203 New peptide-based vaccines to target melioidosis
Krisztina Kiss, Julen Tomás-Cortázar, Siobhán McClean, Viktor Farkas, Kata Horvati
P207 Functional and Bioinformatic Analysis of Antimicrobial Peptide Derived from Lactic Acid Bacteria
Sylwia Nawrot, Natalia Czarnecka, Magdalena Jankowska, Agnieszka Jablonska-Wawrzycka, Patrycja Rogala, Grzegorz Czerwonka
P208 Mapping the G-Quadruplex Binding Determinants of a Vimentin-Derived Peptide by Alanine Scanning
Martina Rotondo, Nicola Dal Ponte, Marta Cozzaglio, Riccardo Rigo, Barbara Biondi, Claudia Sissi
P209 Design, Synthesis, and Biological Evaluation of Triazolyl-Bridged Antiviral Peptides Against Arboviruses
Shima Siadohoni, Michael Quagliata, Silvia Bracci, Rosaria Arvia, Simone Giannecchini, Anna Maria Papini, Paolo Rovero
P212 New antimicrobial peptides on the horizon: comprehensive investigation of bioactive peptaibols for future practical application
Dóra Balázs, ákos Rozsnyói, Henriett Hunkár, Gergo Terna, Fanni Kovács, András Szekeres, Mónika Varga, Csaba Vágvölgyi, Tamás Papp, Tamás Marik, Chetna Tyagi, László Kredics
P214 Synthesis and Antimicrobial Activity of Cyclic Temporin L Analogues via Non-Conventional Guanidinium-Based Functionalization
Ida Boccino, Rosa Bellavita, Bruno Casciaro, Paolo Grieco, Maria Luisa Mangoni, Francesco Merlino
P215 Design and characterization of monoclonal antibody peptide mimics
Lais Callo, Océane Ricloux, Quentin Laurent, Liliane Guerente, Véronique Frachet, Didier Boturyn
P216 Concentration-Dependent Mechanisms of Melittin-Induced Membrane Destabilization: an Interdisciplinary Approach
A. Chacón Calderón, P. Zelenovskii, M. Soares, E. C. Wrobel, O. N. Oliveira Jr., D. Pereira, M. Sardo, L. Mafra, I. Marin Montesinos, A. Barros-Timmons
P217 Guiding Peptide Nanonet Formation and Antibacterial Activity via Hydrophobic Aromatic Ring Engineering for Sepsis Control
Wei Meng Chen, Haoting Shi, Jun Hao Chiew, Ho Ying Low, Jan Kazimierz Marzinek, Din Bao Nguyen, Khai Shuen Heidi Lek, Zhi Wen Tay, Peter John Bond, Pui Lai Rachel Ee
P220 Broad-spectrum antiviral activity of Ranalexin-1G against respiratory viruses
Laura Di Clemente, Carla Zannella, Francesca Palma, Roberta Della Marca, Marina Acunzo, Carla Capasso, Annalisa Chianese, Rosa Giugliano, Anna De Filippis, Massimiliano Galdiero
P221 Rational structure-based design of potent antimicrobial peptides using artificial intelligence
Brigitte Fernández Garcia, Jordi Gómez Borrego, Roberto Bello Madruga, Marc Torrent Burgas
P223 Dual Approach To Reduce Toxicity In Polymyxins And Regain Activity Against Colistin-Resistant Strains
F. Rabanal, E. Asensio, M. Backberg, P. Baranczweski, Y.Cajal, F. Deroose, A. Ginosyan, M. Gros, M. I. Farfán, K.S. Jensen, K. Kloditz, E. Liepinsh, Z. Ling, C. S. Matias, A. Saleh, C. Vingsbo-Lundberg, T. R. Walsh
P224 Chemical Engineering of Transcription Factors Uncovers Cell-Permeable uMax Modulators
Omer Harel, Ferran Nadal-Bufi, Raj V. Nithun, Yumi M. Yao, Ariel Afek, Marc Vendrell, Muhammad Jbara
P225 In vivo evaluation using C. elegans, on the bioactive potential of synthesized dipeptides previously identified in Spanish dry-cured ham.
Noelia Hernandez Correas, Luis Tejada, Adela Abellan, Andrea M. Liceaga.
P226 Stereochemistry vs Linker: Exploration of Ring C Analogues of Antimicrobial Peptide Nisin
Fiona L. Kinnis, William T.P. Darling, Mate Erdelyi, Alethea B. Tabor
P227 Zwitterionic lipid head group influence on the adsorption of antimicrobial peptide to the model lipid membrane
Vedrana Krajnovic, Andreja Jakas, Danijela Bakaric
P228 Bioactive Skin Peptides from Caudate Amphibians: Structural and Functional Insights
Lorena Kröner, Jutta Meier, Marie-T. Hopp
P230 Development of new peptide-based antimicrobial agents targeting trans-translation in bacteria
Flore Miomandre, Andrés Corral Lugo, Olivier Delalande, Emmanuel Guidice, Sophie Chat, Francois-Hugues Porée,Charlene Gadais, Reynald Gillet
P232 Shortened Aurelin-Derived Peptides: The Role of Derivatization in Modulating Antimicrobial Efficacy
Lea Pašalic, Anna Marin, Jasmina Tuzlak, Nermina Malanovic, Andreja Jakas
P233 Multifunctional Short Chimeric Peptides: Potential Antimicrobial Activity and Enhanced Cell Proliferation for Tissue Healing
Naiara Maia Pereira, Reinaldo Marchetto
P234 Synthesis, Characterization and Microencapsulation of the Antimicrobial Peptide Ctx(Ile21)-Ha for Necrotic Enteritis Control in Broiler Chickens
Rayssa Piton Rijo Costa, Andrea B. Meneguin, Mariana Q. Nascimento, Cesar A. Roque-Borda, Silvio R. Teixeira, Marcus Chorilli, Eduardo Festozo Vicente
P235 Targeting the SARS-CoV-2 fusion mechanism: potent peptide inhibitors of the IFP-MPER interaction
Michael Quagliata, Maria Alfreda Stincarelli, Andrea Di Santo, Rosaria Arvia, Shima Siadohoni, Sonja Bazhenova, Feliciana Real-Fernandez, Daniel Friedrich, Simone Giannecchini, Anna Maria Papini, Paolo Rovero
P236 OBOC libraries targeting the SIRPa/CD47 axis: from combinatorial diversity to checkpoint modulation
Paula Quesada-Martinez, Macarena Sanchez Navarro
P237 Targeting beta-PIX SH3 domain-mediated protein-protein interactions in breast cancer using peptide inhibitors
Srijon Sen, Soumya De
P238 Rational Design of Melittin-Derived Peptides for Enhanced Biological Activity
M. Sleziak, J.J. Panek, T. Janek, A. Jezierska, K. Cieslik-Boczula, M. Kijewska
P239 Rational design and synthesis of bioactive miPEP205-derived fragments as modulators of Wnt/β-catenin signaling in triple-negative breast cancer
Francesco Tammaro, Carlo Irace, Maria Grazia Ferraro, Marialuisa Piccolo, Stefania Galdiero, Rosa Bellavita, Paolo Grieco
P245 Hydrophilic-Interaction-Chromatography (HILIC) as a Go-To Alternative for Synthetic Peptide Analysis and Purification
Yiping Wu, Daniel Tietze, Annika L. Weinmann, Linda Thunberg
P246 Bioassay-guided peptidomic characterization of antioxidant peptides generated from corn gluten meal using SSF-produced subtilisin BPN
N. Drulovic, M. Pavlovic, M. Ristovic, A. Leonardi, I. Krizaj, S. Orhanovic, B. Dojnov, M. šokarda Slavic
P247 Comprehensive Chromatographic and Mass Spectrometric Approaches for in Vitro Analysis of Site-Specific Antibody-Peptide Conjugates
Niklas van den Bergh, Eric Mühlberg, Barbara Roether, Walter Mier
P248 Engineering the MALDI interface for in situ detection of modified peptides in synovial fluids : application to osteoarthritis diagnosis
Ugo Pasco, Lomane Berthy, Emeline Groult, Robert Thai, Fabrice Beau, Daniele Noel, Laurent Devel, Gilles Subra, Sonia Cantel
P250 Transfer Learning for Prediction of Liquid-Liquid Phase Separation
Karlo Barjaktaric, Patrik Paunovic, Leonard Lecic, Erik Otovic, Joana Calvário, Ana Sofia Pina, Yoshimasa Kawaguchi, Daniela Kalafatovic, Goran Mauša
P251 Computational approaches for analysis and design of peptides containing non-canonical amino acids
Rodrigo Ochoa
P252 AI-driven generative peptide design targeting GC-C dimer for Parkinson's
Elpiniki Paspali, Lars van der Heide, Ioana M. Ilie
P256 PeptiDesCalculator 2.0: a next-generation descriptor platform for peptide informatics, sequence analysis, and QSAR modeling
Laureano E. Carpio, Rafael Gozalbes, Eva Serrano-Candelas
P257 Beyond natural amino acids: extending immunogenicity risk assessment to non-canonical peptide drugs through chemical feature encoding
Maria Cairoli, Catherine Betts, Morten Nielsen, Olga Obrezanova, Leonardo De Maria
P261 An Integrated Ai-Guided Pipeline For Antimicrobial Peptide Discovery And Optimization
Maryam Nawaz, Ma Tianyue, Fahad Akhtar, Liu Hongyu, Amna Farooq, Heng Zheng
P263 Decoding Pentapeptide Self-Assembly Using Molecular Dynamics: From Aggregation To Architecture
Shimanto Roy, Camille Bilodeau, Kyle Lampe
P264 Active Learning-Driven Surrogate Modeling for the Generative Discovery of Self-Assembling Peptides
Denis Ibiši, Daniela Kalafatovic, Goran Mauša
P266 Peptides involved in interaction with heavy metals for environmental remediation, an in silico approach.
Ximena Carolina Pulido, Hector Fabio Cortes Hernandez, Cesar Jaramillo-Páez
P267 Adaptive Evolutionary Optimization for the Discovery of Self-Assembling Peptides
Milica Injac, Ena Drazic, Marko Njirjak, Gordana Rakic, Daniela Kalafatovic, Goran Mausa
P268 Machine Learning-driven Prediction of Circular Dichroism Spectra for Peptides through Multi-scale Structural Descriptors
Michele Casoria, Marina Macchiagodena, Paolo Rovero, Claudia Andreini, Anna Maria Papini, Marco Pagliai
P269 Inverse folding improves structure prediction for confidence-aware peptide deorphanization
Alexis Dougha, Samuel Murail, Jerome Leprince, Pierre Tuffery
P270 Can we Confidently Sequence the Peptide Dark Matter? Reaching a Consensus for De Novo Peptide Sequencing
Sebastian Johannes Eder, Manuela Schmidt, David Gomez-Varela
P274 AI-driven discovery of cross-kingdom peptide ligands
Marin Matic, Alexander S. Hauser
P275 TFA-Free Cleavage and Deprotection in Solid-Phase Peptide Synthesis: Advantages and Drawbacks of Formic Acid
Maria Leko, Polina Filippova, Sergey Anisimov, Andrey Murko, Sergey Burov
P276 Application of an Automated System for Flow Solid Phase Peptide Synthesis
Manish Kumar, Łukasz Berlicki
P277 Green Liquid-Phase Peptide Synthesis (LPPS) Methodology for the Sustainable Production of Therapeutic Peptides
Naoki Nishizawa, Haruka Machida, Ryo Hatakochi, Yuji Mimori, Akihiro Nagaya, Michiharu Handa
P278 Tag-Assisted Peptide Synthesis (TAPS) - Development of a continuous liquid-phase process
Stefan Peters, Tim Kramer, Mareike Helmdach, Fabian Hogenkamp, Andreas Heindl
P280 Racemization-Free Peptide Synthesis In Water Under Batch And Flow Conditions
Sri Hari Anandhi Rajendran, Sándor B. ötvös, C. Oliver Kappe, Wilfried M. Braje, Matthew Burns
P283 Reusable Photoredox Catalysts for Sustainable Peptide Synthesis
Kelly Materna, Duilio Bacigalupo
P284 TBDC Salts: Advanced Coupling Reagents For Liquid Phase Peptide Synthesis (Lpps)
Nicola Patrian, Dario Corbisiero, Riccardo Grigolato, Alessandra Tiberti, Leonardo Rapisarda, Lucia Ferrazzano, Alessandra Tolomelli, Walter Cabri
P286 ?-Valerolactone-sulfuric acid: a sustainable alternative to TFA for efficient peptide cleavage and global deprotection
M.C. Scala, M. Rega, M. Landi, P.Campiglia, M.Sala
P289 Chemo-Selective Catch-and-Release Purification: An Orthogonal Alternative When Chromatography Fails
Robert Zitterbart, Dominik Sarma
P290 Towards Greener Solid-Phase Peptide Synthesis: Combining a Novel Support with Eco-Friendly Solvents
Luana Lastella, Marco Zecca, Paolo Centomo, Karel Jerabek, Fernando Formaggio, Ivan Guryanov, Marco Macis, Antonio Ricci, Barbara Biondi
P293 Enantioselective synthesis of antiplasmodial cyclic tetrapeptide Koshidacin A
Preeti Kapri, Devki Nandan, Ramesh Ramapanicker
P295 Fishing for Function: From Predicted Binding to Functional Block by a Cone Snail Peptide
Izhar Karbat, Sapir Nutkewitz, Daria Adam Steinberg, Maital Katz, Eitan Reuveny
P296 Efficient TEV tag-assisted one-pot protein semisynthesis
Benoit Snella, Magalie Sénéchal, Jérome Vicogne, Vangelis Agouridas, Oleg Melnyk
P297 Beyond SMCC: Uniform Isothiocyanate-Peptide Bioconjugates
Barbara Roether, Eric Mühlberg, Niklas van den Bergh, Uwe Haberkorn, Walter Mier
P299 Glycerol-derived drop-in solvents for sustainable and more efficient peptide synthesis
Vincent Freiburghaus, Tom Nelis, Jeremy Luterbacher, Nina Hartrampf
P300 Towards the improvement of non-canonical amino acid incorporation via Decoupled Synthesis of Ribosomes (DeSyR)
Benedikt Golisch, Anton Meier, Martin Weissenborn
P302 Eco-Friendly SPPS: overcoming challenges in cosmetic Argireline production
Lucrezia Sforzi, Fosca Errante, Robert Zitterbart, Manoj Kumar Muthyala, Stephan Lüdtke, Dominik Sarma, Anna Maria Papini, Paolo Rovero
P303 Selective peptide bond formation via side chain reactivity and self-assembly of abiotic phosphates
Arti Sharma, Kun Dai, Charalampos G. Pappas
P304 Analogs of [D-Phe4]CJ-15,208 with modifications to improve kappa opioid receptor antagonist potency in the CNS as potential treatments for substance abuse
Jane Aldrich, Jeremy Coleman, Moustafa Hamaad, Brian Knapp, Ryosuke Shinouchi, Megan Quinones, Andrew Watson, Shainnel Eans, Jean Bidlack, Jay McLaughlin
P305 Decoding Heme-Gai Protein Crosstalk with Peptide Tools
Sabriye Aydogdu, Sonali M. Vaidya, Diana Imhof
P307 Discovery and Optimization of an mRNA Display Cyclic Peptide inhibitor of the IL1b/IL1R Interaction
Stefania Colarusso, Francesca Pavone, Elisabetta Bianchi, Roberto Iaccarino, Emanuela Mandic, Emanuela Nizi, Willy Costantini, Martina di Geronimo, Faben Cruz, Dennis Feng, Yan Guo, Jennifer Hanisak, Charles Jayne, Ahmet Kekec, Angelea Kerekes, Victor Mak, Michael Lo, Jennifer Hickey, Christopher Plummer
P312 Discovery of Potent RSV Peptides Antivirals
Origene Nyanguile, Nadege Pidoux, Stéphane Duquerroy, Mathilde Keck, Thibaut Larcher, Marie Galloux
P313 Developability screening of pharmaceutical peptides
Marie Pedersen, Rodrigo Ochoa, Mathias Norrman, Christian Tornoe, Sebastian Swanson, Jacob Larsen, Stephanie Hansen, Alexander Büll
P314 Two New Orbitides, [1-10-NaC]-croheorbs A1 and A2, Isolated from the Latex of Croton heliotropiifolius
Suzana A. S. Queiroz, Ana Leticia P. Dos Santos, Paula Rezende-Teixeira, Leticia Costa-Lotufo, Vanderlan S. Bolzani
P315 Chemical synthesis and evaluation of insulins derived from a venom insulin of the cone snail Conus geographus
Nicholas Schumann, Amber Vogel, Reza Moosavi, Zildjian Acyatan, Christopher Hill, Helena Safavi-Hemami
P317 Targeting Neurodegenerative Diseases with Priavoid's Peptide Drug Development Platform
Mathias Wendt, Marc Sevenich, Kira Allmeroth, Gina Hartmann, Karolina Korostov, Antje Willuweit, Dieter Willbold
P319 A cardiolipin-targeting a-helical bundle peptide stabilizes inner membrane of mitochondria, down-regulating ALCAT1 to shut down pathogenic remodeling in oxidative stress condition
Yoonhwa Choi, Tae Yeon Kim, Hyeong Woon Choe, Gwangsu Shin, Seung Hee Yang, Hyo Youl Moon, Jaehoon Yu
P325 Mirror-Image Random Nonstandard Peptides Integrated Discovery (MI-RaPID) Technology Yields Highly Stable and Selective Macrocyclic Peptide Inhibitors for Matrix Metallopeptidase 7
Hiba Ghareeb, Choi Yi Li, Anjana Shenoy, Naama Rotenberg, Julia M. Shifman, Takayuki Katoh, Irit Sagi, Hiroaki Suga, Norman Metanis
P327 A PCSK9 Vignette: From mRNA Display to Passively Permeable Macrocycles
Yuhua Huang
P328 Preparation of peptides and their inhibitory activity effects against BACE1
Shinji Katsuoka, Daisuke Nakashinn, Taeko Kakizawa
P330 Novltex: A New Class Of Antibiotics With Potent Activity Against Multidrug Resistant Bacterial Pathogens
Esra Malkawi, Anish Parmar, Ishwar Singh
P331 Optimization and Selection of ASF1-Binding Peptides with optimized quantitative bacterial two-hybrid Using qB2H
Francoise Ochsenbein, Antoine Guyot, Emma Maillard, Kelly Ferreira-Pinto, Laure Plancon-Arnould, Aravindan A. Nadaradjane, Raphael Guerois, Loic Martin, Oscar H.P. Ramos
P333 Unlocking Macrocycles at Scale with nGen: Integrated High-Throughput Synthesis and Generative AI
Herve Siendt, Mischa Schüttel, Zander Harteveld, Sevan Habeshian, Chiara Toniolo, Sara Cristinelli
P334 Amide-to-Chloroalkene Substitution as Peptide Backbone Modification for Enhancement of Membrane Permeability
Sayuri Takeo, Mio Takeda, Chihiro Iio, Ai Sakakibara, Showmitra Saha, Natsuki Shibata, Yuki Yamazaki, Takahiro Fujii, Ryuhei Harada, Kohei Sato, Nobuyuki Mase, Mizuki Watanabe, Takanori Oyoshi, Tetsuo Narumi
P336 Mapping and Linking Druggable Sites on Rad6 Using Proteomimetic Fragments and AI-assisted Design
E. Wéber, F. Bogár, B. Nagymihály, M. R. F. Mohamed, é. Bartus, A. Tököli, Z. Kupihár, G. M. Keseru, T.A. Martinek
P337 RaPID Selection of Nonstandard Thioisoindole-Bridged Bicyclic (TiB) Peptides Targeting TNIK
Yue Zhang, Hiroaki Suga
P339 Affibody-mediated Peptide Nucleic Acid Pretargeting Using Dual Hybridization Sequences for Increased Therapeutic Potential
Jacob Clinton, Kristina Westerlund, Amelie Eriksson Karlström
P344 New Positive Allosteric Modulators for u Opioid Receptor from Oxytocin
Takaaki Mizuguchi, Kanako Miyano, Ami Yamazaki, Hideki Takahashi, Risa Yamauchi, Yuki Yoshida, Haruka Ono, Miku Inagaki, Miki Nonaka, Yasuhito Uezono, Hideaki Fujii
P346 Design And Synthesis Of Novel Desmuramyl Peptide Glycoconjugates
Vesna Petrovic Perokovic, Zeljka Car, Jelena Pavic, Luka Sumic, Rosana Ribic
P347 PDGF-Derived Peptides: From Receptor Binding To Cellular Signaling In Wound Healing
Krzysztof Polaczek, Przemyslaw Karpowicz, Malgorzata Zawrzykraj, Milena Deptula, Michal Pikula, Emilia Ilowska, Rafal Slusarz, Emilia Sikorska
P354 Targeting HER2-Positive Breast Cancer With a New Affibody-Nanodrug System
Ewa Wieczerzak, Milena Czeszejko, Patrycja Rachubik, Daria Sowik, Justyna Sawicka, Kamila Kitowska, Rafal Sadej, Sylwia Rodziewicz-Motowidlo
P356 Synthesis And Characterization Of Thermo-responsive Magnetic Molecularly Imprinted Polymers For Selective Recognition Of Peptide-drug Conjugates
Sima Alvani Alamdari, Justyna Fraczyk, Sebastian Schwaminger
P357 Synthesis of PLGA Nanoparticles Encapsulated with Immunodominant MOG35-55 Peptide Analogues for the Treatment of Multiple Sclerosis
Georgia Biniari, Iro Triantafyllakou, Carmen Simal, Spyridon Mourtas, Theodore Tselios
P364 Novel macrocyclic peptide-based uPAR-targeting fluorescent probes for intraoperative fluorescence imaging
Tuule Treiberg, Nadia Hajib, Kasper Kildegaard Sorensen, Mikkel Boas Thygesen, Karina Straede, Knud Jorgen Jensen, Andreas Kjaer
P368 From small molecules investigated as Factor XIIIa Inhibitors to biological target diversity
Ivan P. Bogdanov, Nikolay T. Tzvetkov
P369 A Cardiolipin-Targeting a-Helical Bundle Peptide forms Self Assembled Trimer to Facilitate Cell Penetration and Stabilizes Inner Membrane to Rejuvenate Mitochondrial Dysfunction
Hyeong Woon Choe, Yan Lee, Jaehoon Yu
P370 Design And Development Of Novel Low-Molecular-Weight Carboxamides As Dual Modulators Of Mao-B And ?-Synuclein
Georgi I. Ivanov, Nikolay T. Tzvetkov
P371 Harnessing nature's defences to treat gut biofilms
Bernhard Jandl, Michaela Lang, Athanasios Makristathis, Christoph Gasche, Markus Muttenthaler
P373 Multifunctional Bone-Targeting Peptides for Inhibition of the RANK-TRAF6 Interaction
Sofia Martins, Catia Rosa, Marco Cavaco, Rita Melo, David Andreu, Javier Valle, Vera Neves, Miguel Castanho, Sandra Casimiro; Joao Correia
P376 Development of PNA-Peptide Chimeras targeting G-quadruplex structures
Matilde Rossi, Paola Gratteri, Ines Neundorf, Carla Bazzicalupi, Daniel Friedrich, Anna Maria Papini
P377 Antidiabetic Effects of Cyclotide-Rich Extracts from Selected Nigerian Medicinal Plants: An Ethnopharmacological Approach
Latifat O. Sidiq, Abraham O. Nkumah, Omonike O. Ogbole
P378 Targeting GLP-1 Receptor and DPP-4 Enzyme for Diabetes Drug Discovery
Aditi Singh, Soumendra Rana
P379 Mechanistic Insights into Antimicrobial Peptide-Extracellular Vesicle Interactions and Therapeutic Applications in Sepsis
Tasvilla Sonallya, Tünde Juhász, Imola Cs. Szigyártó, Kinga Ilyes, Kata Horvati, Yumi Kumagai, Zoltán Varga, Tamás Beke-Somfai
P381 Non-destructive quantification of peptide trifluoroacetates
Charity D. Yongo-Luwawa, Nassim Maarouf-Mesli, Ida Boccino, Karen C. Waldron, William D. Lubell
P384 A Nanometric Platform for Live Cell Multiplex Screening of Non-natural Peptides
Sinyal Abu-Rabia, Danit Zagiel, Coral Yohay, Gila Kazimirsky, Gerardo Byk
P386 Innovative phage display libraries for precision protein targeting
Cristina Diaz-Perlas, Benjami Oller-Salvia, Christian Heinis
P388 Assessing the Efficacy of Peptides on Acute Coronary Syndrome In-vivo
Offir Ertracht, Rani Wainer Shlomo, Mulate Zerihun, Shulamit Fluss Ben-Uliel, Shmuel Silitsky, Samar Gani, Liron Davis, Mona Shehadeh, Tali Reuveni, Shaul Atar, Nir Qvit
P389 Microfluidics-Driven Assembly of Sonoresponsive Peptidic Nanoparticles for Ultrasound-Mediated Gene Delivery
Guy Gouarin, Vicentiu Moraru, Samir Cherkaoui
P393 Application of Antibody Site-Specific Modification Method tCAP to Brain-Penetrating Antibody-Oligonucleotide Conjugate
Yuji Ito, Abdur Rafique, Hiroko Kawakami, Taku Yoshiya
P394 Engineered Peptide-Based Nanosystemsfor Improving Therapeutic and Diagnostic Potential of Anticancer agents
Prashant Mishra, Ritu Bhardwaj
P399 Multifunctional Bioactive Cotton: Synergistic Antimicrobial and Regenerative Properties through Chemoselective Peptide Conjugation
Francesca Albini, Adriana Di Stasi, Mario Mardirossian, Barbara Biondi, Cristina Peggion
P400 Hybrid Peptide Functionalized Nanoparticles For Breast Cancer Therapeutics
Priyanshu Priya, Peter M Moyle, Zyta M Ziora, Prashant Mishra
P401 Making new PALs: A Directed Evolution Platform for Rapid Peptide Asparaginyl Ligase Engineering
Simon Tang, James Leech, Zihao Song, Louis Luk, Jody Mason
P403 Development of pH-Responsive Peptide Systems for mRNA-Mediated Antimicrobial Peptide Delivery
Hala Alnasif Alhadi, Tam T. Bui, Jenny Lam, Vincenzo Abbate, A. James Mason
P404 Peptide Stability in GMP-Manufacturing: Minimizing Risk to Peptide Drugs from Single-Use Assemblies
Stephanie Bellmaine, Sarah Parsons
P405 A Multifunctional Thermoresponsive Micellar Hydrogel System for Targeted Skin Depigmentation, Enhanced Dermal Penetration, and Extracellular Matrix Stimulation
Yajima Campos Mora, Luis Javier Cruz, Yaimara Solis, Julio Cesar Aguilar, Gerard Esteruelas, Elena Sanchez, Marta Espina
P408 Engineering Anticancer Peptides To Improve Oral Bioavailability Via Lipidation
Giuseppina Guida, Aurelie Benfield, Nicole Lawrence, Sonia T. Henriques
P411 Peptide-Based Surface Engineering of Biomimetic Liposomes for Biomedical Applications
Giulia Lodigiani, Roberto Frigerio, Alessandro Gori, Francesca Baldelli Bombelli, Greta Bergamaschi
P412 The development of topical formulations of liposomal micrococcin P1 for wound infections
Bezael Gurmessa, Colin Charnock, Kirill Ovchinnikov, Tage Thorstensen, Sanko Nguyen
P413 Preliminary evaluation of the stability of a liposomal formulation of OmegaCalm based on active peptides for cosmetic applications
Y. Solis, Yaima Campos, Julio Cesar Aguilar, Gerad Esteruelas, Elena E. Sánchez, Luis Javier Cruz
P419 Peptidoglycan-Based Biomimetic Nanomaterials Reveal Lectin Recognition In Dap-Type Bacteria: Toward Rational Design Of Antimicrobial Therapeutics
R. Frkanec, Marcela šišic, Anne Imberty, Antonija Tomic, Andrea Usenik, Vladislav Tomišic, Leo Frkanec
P420 Peptide Microarray Platform For High Throughput Discovery And Optimization Of Protein-Binding Peptides
Sravanthi Guggilapu, Ryan Clark, Geoff Eddinger, Ken Lo, Sarah Fahlberg, Eric Sullivan, Lauren Goodrich
P422 Phage display validation of lysosomal targeting receptors for the treatment of lung cancer
Vanesa Nozal, Petar Petrov, Juan Sebastián Ruiz, Benjami Oller-Salvia, Cristina Diaz-Perlas
P424 Characterization of a Novel Thiazole-Installing RiPP Maturase from Acidobacteriota
Dora Racunica, Daniel Richter, Anda Pop, Jörn Piel
P425 Transcending Amino Acid Limitations: Enzymatic Halogenation for Phage Display Diversification
Richard Schreiter, Leonard Kaysser, Christina Lamers
P426 ADMET of peptides: Are we there yet?
Canay Yildiz, Nicola Köhler, Amy Park, Toni Kühl, Diana Imhof
P429 Rational Design of Fc-Binding Peptide Ligands as Next-Generation Alternatives to Protein A for Antibody Purification
Tuba Polat, Alp Ertunga Eyupoglu, Ahmet Can Timucin, Batu Erman, Tanil Kocagoz, Ozge Can
P430 Bifunctional de novo peptides to tackle antimicrobial resistance
Lucie Bastien, Emna Ben El-Hadj Salem, Pauline Samper, Mehavi Mehavarnan, Eric Pardoux, Arnaud Buhot, Muriel Jourdan, Didier Boturyn, Sandrine Boisset, Yoann Roupioz
P435 Design of smart peptide-based nanoparticles for siRNA delivery in gastrointestinal stromal tumors (GIST)
Thania Hammoum, Jules Vastra, Julien Fabre, Karidia Konate, Eric Vives, Sandrine Faure, Pascal de Santa Barbara, Sébastien Ulrich, Prisca Boisguerin
P438 Self-assembly control with hydrophobicity gradients in short peptide sequences
Irene Toledo, Natalia Baranova, Ivan Sasselli
P439 Nuclear Delivery of Antibodies for the Modulation of TDP-43 Liquid-Liquid Phase Separation
Daisuke Yamasaki, Yoshimasa Kawaguchi, Miki Imanishi, Shiroh Futaki
P440 Synthesis of MUC1 Tn/Sialyl-Tn Glycopeptides and Combinatorial Libraries for Lectin Binding Studies
Mare Cudic, Ivet Boneva, Ramya Ayyalasomayajula, Donella Beckwith, YashoNandini Singh, Sabine Andre, Herbert Kaltner
P442 Impact of glycoclustering on the structure of mucin peptides
Oliver Seitz, Arseniy Galashov, Elisabetta di Gregorio, Polina Ponomareva, Marc Safferthal, Ekaterina Kazakova, Leila Bechtella, Kevin Pagel, Marina Pigaleva, Benesh Joseph, Kim Greis, Lyna Bourehill, Renato Zenobi
P443 Target, Capture, Treat -Peptide Nucleic Acid (PNA)-Guided Pretargeting for HER2-Targeted Antibody-Mediated Radionuclide Therapy
Kristina Westerlund, Mohamed Altai, Wahed Zedan, Jacob Clinton, Susanne Geres, David Ulmert, Amelie Eriksson Karlström
P444 Parallel-Stranded Design of Peptide Nucleic Acids for Efficient Recognition of Double-Stranded DNA
Yuichiro Aiba, Masanari Shibata, Hiroshi Sugimoto, Osami Shoji
P446 Biosynthetic Peptide Screening Platform for various Drug Discovery and Delivery
Shin Izuta, Taishi Fuda, Hiroki Takahashi, Koo Suzuki, Nao Yamazaki, Anri Nishiguchi, Tomoki Ota, Ryo Ukekawa, Yukiko Ishii
P447 Structural characterization of fatty acid modifications in ribosomally encoded N-acylated lipopeptides
Julien König, Johannes Eckert, Ian Yunus, Gabriel Cervera Arriaga, Anna Vagstad
P449 Radiolabelling in the New Age of Peptide Therapeutics
Cian Reid, Roger Glanville, Yukuang Guo, Eric Ballard, Sean Zhu
P453 Peptide-Oligonucleotide Conjugates: Effect on Endosomal Escape?
Fie Davidsen, Kolfinna Hjálmarsdóttir, Adrian Hernandez, Ewa Sitarska, Anand Saminathan, Tom Kirchhausen, Knud J. Jensen
P454 Investigation of the interactions between mannosylated desmuramyl peptides and mannose-binding proteins
Marija Paurevic, Vesna Petrovic Perokovic, Zeljka Car, Rosana Ribic
P455 Synthesis and FRET-Based Cleavage Study of an aVβ6-Targeting Peptide Drug Conjugate
Caroline Brinkmann, Andreas Brockhinke, Norbert Sewald
P457 Photocatalytic Proximity Labelling to Probe Cell Surface Glycan Interactomes
Jerrard Hayes, Mia Huang, Eoin Scanlan
P458 Engineering antimicrobial peptides through nanocarrier surface design and intracellular targeting for tuberculosis therapy
Cesar Augusto Roque-Borda, Laura MDG Primo, Christian S.C. Canales, Eduardo F. Vicente, Joao Perdigao, Beatriz G. de la Torre, Fernando Albericio, Henrik Franzyk, Paul Robert Hansen, Fernando R. Pavan
P459 De novo Design and AI-supported Flow Synthesis of Catalytic Miniproteins
Manish Kumar, Ewa Rudzinska-Szostak, Anna Szczepanska, Lukasz Berlicki
P461 Deciphering the Fluorous Effect in Protein Quaternary Assembly
David Reiter, Jacob S. Jordan, Javier Camargo Diaz, Malkeet Singh, Moritz Engl, Kevin Pagel, Beate Paulus, Mario Schubert, Christian Roth, Beate Koksch
P464 Exploring the Design Space of 310-helical Bundles using Non-canonical Amino Acid
Xiyue Leng, Jonathan Clayden, Derek N. Woolfson
P466 Uncovering the structural logic of Cnn autoinhibition: an integrative NMR, SAXS, and AlphaFold approach
Arthur Vitard, Abir Elfarkouchi, Nicolas Joly, L. Mammri, Sébastien Brier, Lola Tanneur, Cécile Hu, Aurélien Thureau, Nicolas Joly, Francoise Ochsenbein, Paul Conduit
P469 Evolutionarily Conserved Amyloid Architecture in the PACAP–Glucagon Peptide Superfamily
Dániel Horváth, Zsolt Dürvanger, Szebasztián Szaniszló, Anna Kiss-Szemán, Duong Kim Hoang Yen, Michael Hons, Meytal Landau, András Perczel
P470 Twist in the Tail: Capping Turns Modulates Collagen Thermal Stability
Aritra Naha, Amar Ghosh, Bani Kanta Sarma
P474 NMR - Restrained Structural Elucidation of Mitoxantrone Conjugates with GnRH Peptide Analogues
Carmen Simal, Georgia Biniari, Haralambos Tzoupis, Nikitas Georgiou, Thomas Mavromoustakos, Theodore Tselios
P475 Stabilization of Helical Structures in Oligopeptides Through Modification of Phenylalanine Residues
Vikrant Vini, Jisna T., Prema G. Vasudev, Ramesh Ramapanicker
P476 Conformational complexity of the disordered N-terminal region in biological function of tumor suppressor p53 protein
Elena Zindovic, Moath Yousef, Edwige Voisset, Vladimir Torbeev
P478 Conformational Effects of Fluorinated Aminocyclopropane Carboxylic Acids Incorporation in Peptides
Eliott Roy, Zoé Weber, Baptiste Legrand, Thomas Poisson, Ludovic Maillard, Philippe Jubault, Florine Cavelier
P479 Turning Peptides with Cyrene-Derived Amino Acid Residues
Kajumee Bora Bhowal, William D. Lubell
P483 Dual Peptide Strategy for Enhanced Rescue of Mutated CFTR Channel Function in Cystic Fibrosis
Prisca Boisguérin, Clémentine Teko-Agbo, Chloé Felgerolle, Maha Sinane, Karine Delétang, éric Vives, Magali Taulan Cadars
P484 Cyclic Peptide-Based Platform for Targeted Delivery to the Brain
Predrag Cudic, Harrison Hutchings, Aleksandra Nedovic, Lucas Costa
P487 A helical peptide antagonist of the human growth hormone receptor
Justin M. Holub, Khairun Nahar, Reetobrata Basu, Arshad Ahmad, Joseph A. Pettis, Udani Gamage, John J. Kopchick
P491 Therapeutic Peptides as Novel Agents Against Ventricular Arrhythmias
Carlos Cuadros-Higueras, Pablo Esteban-Arderius, Enora Trubuil, Sara Pérez-Martin, Josu Rapun, Alba de la Iglesia, M. Jesus Pérez de Vega, Ricardo Caballero, Eva Delpón, Rosario González-Muniz, Diego Nunez-Villanueva
P493 Evolution Did Not Eliminate Aggregation: Functional Amyloids Enable Hormone Storage and Signaling
Dániel Horvátha, Zsolt Dürvanger, Szebasztián Szaniszló, Anna Kiss-Szemán, Duong Kim Hoang Yen, Michael Hons, Meytal Landau, András Perczel
P494 Molecular Mimicry by Venom Peptides
Samuel D. Robinson
P500 Pullulan-Based Microcondensates with Cationic Peptides for Efficient Cytosolic IgG Delivery
J. Michibata, Y. Kawaguchi, S. Futaki
P501 Photoisomerization-Dependent Glycan Binding of Engineered Lectin-like Peptides: Toward Light-Controlled Bioactivity of Lectins
Serhii Kharchenko, I. Semchuk, A. Cherednichenko,V. Hryhorieva, S. Afonin, I. V. Komarov, Anne S. Ulrich
P502 Design and synthesis of therapeutic peptides with anti-inflammatory and regenerative properties for use in the treatment of equine gastric ulcer syndrome (EGUS)
Kinga Marszalek, Ewa Wieczerzak, Krzysztof Marycz, Sylwia Rodziewicz-Motowidlo
P506 A Modular Neuropilin-Hsv Derived Rf-Tuftsin Platform For Targeted Delivery: Validated In Spheroids And Epithelial Barrier Models
K. Uray, M. Krátky, E.L. Méhes, F. Sebák, A. Bodor, F. Zsila, T. Visnovitz, T. Bárkai, F.K. Grébecz, K. Fodor, L. Lakatos, R. Oláhné Szabó, J. Horcic, J. Vinšová, S.E. Bosze
P511 Selection, synthesis and interaction of hACE2 peptide fragments towards spike protein of the SARS-CoV-2 virus
Aleksandra Czerchawy, Manoj Muthyala, Feliciana Real-Fernandez, Francesca Nuti, Paolo Rovero, Anna Maria Papini, Beata Kolesinska
P512 An opioid-neurotensin hybrid outperforms morphin in acute and chronic pain models
L. Durand-Baudet, J. De Neve, E. Breault, S. Gonzalez, V. Utard, E. Vangeloven, F. Simonin, P. Sarret, S. Ballet
P516 Rational Design and Structure-Activity Relationship of Spider- and Snake-Venom-Derived Peptides Targeting Acid-Sensing Ion Channels
Nataliia Petlovana, Serhii Kharchenko, Tessa Sussek, Vladyslava Hryhorieva, Fabian Hoffmann, Illia Hutskalov, Iryna Semchuk, Sergiy Afonin, Jan Tytgat, Anne Ulrich
P517 Design of biased GPCR modulators by combining artificial intelligence and molecular simulation
Alaa Reguei, Samuel Murail, Serge Luquet, Franck Oury, Pierre Tuffery
P519 Targeted Inhibition of Fis1/Mfn1 Protein-Protein Interactions with Peptides Promotes Cardioprotection
Ayetenew Abita, Hellena Shumaff, Liron Davis, Nir Qvit
P521 Enhancer-driven changes in Peptide Permeability on In Vitro models
Josip Mihalac, Astrid Milic, Daniela Kalafatovic
P522 A multimodal molecular toolbox for in vitro and in vivo studies of the oxytocin receptor
Monika Perisic Böhm, Predrag Kalaba, Erik Keimpema, Rachel S. Gormal, Frédéric A. Meunier, Thierry Langer, Karine Mardon, Christian W. Gruber, Markus Muttenthaler
P523 AI-Guided Discovery of Anti-Inflammatory Peptides from Edible Rhizomes and Root Vegetables
Kruttika Purohit, Mitchell Low, Fabien Plisson, Evan Hayes, Anwar Sunna
P524 Evaluation of Different Photocaging Strategies to Develop Next-Generation Photoprobes
Konstantin Raabe, Predrag Kalaba, Hilary Yong, Greta Crudeli, Sarah Melzer, Victor Anggono, Erik Keimpema, Markus Muttenthaler
P526 Dynamic PEGylation of Peptide-based Nanoparticles for siRNA Delivery
Jules Vastra, Thania Hammoum, Prisca Boisguérin, Sébastien Ulrich
P528 Graphene Oxide-Peptide Nanofibers As Platforms For Cell Bioactive Responses
C. Garcia Delgado, A. Sánchez-Temprano, I. Obregón-Gómez, MV. Sulleiro, A. Criado, E. Pazos
P529 Hydrogel Formation Via Base-Triggered Conversion Of A Peptide Progelator
Ana M. Garcia, Yasmina Berruga, Polina Topalska, Pilar Prieto, Daniel Iglesias
P530 Peptide-functionalized Nanocoatings for Prevention of Biofouling and Device-Associated Infections
Shubhi Joshi, Avneet Saini
P532 Sequence-Programmed Control of Coacervate Stabilisation Mechanisms Using Modular Peptides
Roi Lopez-Blanco, Willem van den Hout, Sander Huisman, Jan C. M. van Hest
P533 Data-Driven Mapping of Interfacial Properties of Pure and Multicomponent Peptide Amphiphiles
Justin Houx, Marco Kong, Octavia Tao, Pim Dankloff, Gijs Martens, Joost Hoeksel, William Robinson, Wilhelm Huck, Mathijs Mabesoone
P535 A peptide interface for collection and functional analysis of migrasomes
Mina Okochi, Shogo Saito
P538 Optically switched transient amyloid-like fibrils for antibiotic degradation
Shubhra Kanti Bhaumik, Sisira Mambram Kunnath, Elad Arad, Einat Nativ-Roth, Arunavo Chatterjee, Albert Batushansky, Nitzan Shauloff, Hanna Rapaport, Raz Jelinek
P539 Catalytic DNA Degradation by Pancreatic β-cell Peptide Hormone: A New Pathway Towards Amylin Pathology
Arunavo Chatterjee, Uri Ben Nun, Neha Singh, Itamar Kass, Shubhra Kanti Bhaumik, Sisira Mambram Kunnath, Raz Jelinek
P540 An Artificial Light-Harvesting System Built from a Peptide-Based Triaxial Weave
Tatiana Da Silva-Ferreira, Helma Wennemers
P541 Fullerenol-Based Mimicry of LarE-Type Sulfur Insertase Activity
Volkan Dolgun, Antoine Marion, Salih özcubukcu
P543 Computational Exploration of Nanoscale Chemical Patterning Using Short Peptides
Md Jakir Hossen, Adel Nematipour, Camille Bilodeau
P545 Cytoskeleton Stabilized Artificial Cells and their Dynamic Behaviour
Victoria Remacha, Lars Paffen, Andoni Rodriguez, Angshuman Dasm Roi Lopez, Jan van Hest
P548 Amino acid-based hydrogels for electrochemical applications
Sandro Amador, Felipe Conzuelo, Ana C. Baptista, Leonor Morgado, Ana S. Pina
P550 Multifunctional amphicharged and bolaamphiphilic surfactants derived from amino acids: The effect of pH and temperature on their interactions with bovine serum albumin (BSA) and lysozyme (LYZ)
Sumedha Gupta, Neelakshi, Nikita Jain, Ramesh Ramapanicker
P551 Amplifying Magnetic Responsiveness of Self-Assembled Peptide Nanostructures via Synergy of MNP-Helix and Rod-Coil Building Blocks
Seong-Jae Han, Zhihao Zhang, Shouqin Feng, Jeongsu Park, Yong-Beom Lim
P552 From Thermodynamic Stability to Hemocompatibility: Self-Assembling Peptide Nanotubes for mRNA Delivery
Jungyeon Ryu, Hyeonsuk Hwang, Kyuwon Hwang, Taehyun Kim, Yongbeom Lim
P554 From Self-Assembly to Function: Tunable Peptide Fibrils as Nanocarriers
Milena Czeszejko, Justyna Sawicka, Ewa Wieczerzak, Daria Sowik, Patrycja Rachubik, Tomasz Kulesza, Kamila Kitowska, Rafal Sadej, Zuzanna Pietralik-Molinska, Maciej Kozak, Olena Ivashchenko, Sylwia Rodziewicz-Motowidlo
P555 Self-Assembling Peptides Forming Anti-Parallel beta-sheet Nanostructures Cross-Linked with Genipin
Quentin Chenin, N. Follain, Claudia Bello, Luca Rosi, Paolo Rovero, Anna Maria Papini
P556 Peptide Self-assembly Beyond Known Design Principles: Sequence and Context Interplay
Ena Drazic, Helena S. Azevedo, Daniela Kalafatovic
P557 Integrating semiconducting organic polymers with biological systems
Chao Lyu, Bob Schroeder, Alethea Tabor
P558 Allosteric amyloid catalysis by coiled coil fibrils
Sisira Mambram Kunnath, Elad Arad, Elinor Slavsky, Lonia Friedlander, Hanna Rapaport, Raz Jelinek
P559 Self-Assembled Peptide-Au Nanoparticle Hybrid Systems for Catalytic Applications
Vanessa Quattrociocchi, Claudia Pigliacelli, Elena Pazos
P561 Toward Next-Generation ADC Platform tCAP for Site-Specific IgG Modification
Hiroko Kawakami, Abdur Rafique, Shugo Tsuda, Taku Yoshiya, Yuji Ito
P563 Edman degradation beyond standard
Toni Kühl, Alexander Terekhov, Diana Imhof
P564 The antimicrobial peptide Esc(1-21) potentiates CFTR channel via direct targeting of the nucleotide binding domains
Maria Luisa Mangoni, Loretta Ferrera, Giacomo Cappella, Mario Passalacqua, Mattia Mori, Debora Baroni
P616 Screening Cyclised Peptides Inside Cells Identifies a Short Helical Inhibitor of Alpha-Synuclein Aggregation
Scott G. Allen, Richard M. Meade, Amy J. Lopez, Christopher Williams, Iona Thomas-Wright, Bangfu Zhu, Mara Carey-Wood, Julia E. Sero, Vicky L. Hunt, Andrew Brennan, Richard Wade-Martins, Robert J. Williams, Matthew P. Crump, Jody M, Mason
P633 Creating Antibiofilm and Antibacterial Endotracheal Tubes Using Antimicrobial Peptides and Antibiotics
Elizabeth Ogunfeibo, Sam Boateng, Doug Fraser-Pitt, Ying Yang, Wen-Wu Li
